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Blood, Sweat & TearsUsing Biomarkers to Become Superhuman          Justin Mager, MD
Part 1The Big Picture
becoming superhuman    Who really intends to become     Who really intends to become    superhuman here?     superhuman he...
Beware of Experts  Zen Mind is Beginner’s         Mind
need to switch out phenomenon to “process”                                                       need to switch out phenom...
Dynamic ProcessOccurring Across Scales of Time
Collective Process
The monkey business of  Measuring process
Timing/context Matters Measurement and Interpretation
the Trees and the forest
Processes are flowing tides of                         Interconnectedness•   Are Statins Diabetogenic?    •    Meta-Analys...
Quick Recap•   Biomarkers Indicate Process•   Look at Whole Picture•   Must be Taken into Context of    Your Situation•   ...
Hypercholesterolemia•   Total Cholesterol: 390 (mg/dl)•   LDL: 269•   Triglycerides: 329•   HDL: 36
hyperglycemia/Diabetes•   Glucose: 199 (mg/dl)•   HbA1c: 8.5%•   Insulin: 32 (ul U/ML)
Hyperthyroidism/Graves?•   TSH: 8.1 (uIU/ml)•   Total T3: 300 (ng/dl)•   Free T4: 3.2 (ng/dl)
Hypersomatotropism/Acromegaly•   IGF-1: 641 ng/ml
so, What IF....•   Hypercholesterolemia•   Hyperthyroidism•   Hyperglycemia•   Hyperinsulinemia•   Hypersomatotropism     ...
Part IIA Closer Look at a Few Markers
Survival of the Fittest? System Biomarkers
Journal of Obscure and Questionable Medicine                           (JOQM)                                            J...
NEJM•   Each 1 Met INCREASE in exercise capacity conferred a 12% IMPROVEMENT in    Survival•   CONCLUSION: Exercise Capaci...
Meta-Analysis     33 Studies; 102,000 Women              and Men     33 Studies; 102,000 Women              and Men•   Eve...
Telomeres:                  Health, Aging & Disease                  Health, Aging & Disease•   Unique DN-Protein    compl...
Impacting telomeres•   Nutrient Levels    •   Omega-3, D, B-Vitamins•   Stress•   Weight Gain/Loss•   Biomarkers    •   Ho...
functional Biomarkers
HBA1c : Fuel Efficiency•     HgbA1c for Optimal Health       •    5% = 90mg/dl, 6% = 135mg/dl       •    AGE’s (Advanced G...
HbA1c & Fuel Efficiency                                                                                 Insulin           ...
fuel efficiency
methylation: Metabolic Efficiency
Hormones OS• Metabolic of us    •   Thyroid    •   Pregnenolone•   Catabolic    •   Adrenaline    •   Cortisol•   Anabolic
hormone physiology100m Olympic Swimmer     Elite Crossfit Athlete  6’0”, 163 lb., 8% BF   5’9”, 210 lb., 9% BF
summary: Becoming superhuman•   Remember Your Roots•   Look at the Whole    Picture    •   System’s Bio Analysis•   Enhanc...
Age of engagement•   Measurements Matter    •   Adapt & Innovate•   It’s Your Life; Don’t    Take My Word For It.    •   U...
Medimorphisys•   Self Experimentation•   Crowd Sourcing Solutions•   Outcomes Analysis•   Big Data Analytics
Blood, Sweat & TearsUsing Biomarkers to Become Superhuman          Justin Mager, MD
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Blood, Sweat & Tears - Testing Biomarkers to Become Superhuman

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Dr. Justin Mager from WellnessFX ( http://get.wellnessfx.com/cngs ) tells you how to test your blood and test your biomarkers for health, performance and more. Get full access to videos, audios, important notes and more from this presentation at http://superhumancoach.com/heres-your-insider-access-to-the-become-superhuman-experience and for WellnessFX testing, visit: http://get.wellnessfx.com/cngs

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Blood, Sweat & Tears - Testing Biomarkers to Become Superhuman

  1. 1. Blood, Sweat & TearsUsing Biomarkers to Become Superhuman Justin Mager, MD
  2. 2. Part 1The Big Picture
  3. 3. becoming superhuman Who really intends to become Who really intends to become superhuman here? superhuman here? how? how? what are the barriers? what are the barriers? No matter how you plan to get No matter how you plan to get there, BIOMARKERS can play a there, BIOMARKERS can play a key role, Why??? key role, Why???• Set The Intention & Expectation!• Hypothesize & Experiment• Manifest Our Reality• Biomarkers are a Tool to Measure and Track
  4. 4. Beware of Experts Zen Mind is Beginner’s Mind
  5. 5. need to switch out phenomenon to “process” need to switch out phenomenon to “process” this definition is one fundamental problems! this definition is one fundamental problems!biomarker |ˈbīōˌmärkər| we measure, make an aboslute judgement, and then try to we measure, make an aboslute judgement, and then try to “manage the marker” “manage the marker”noun if the marker marks a process, we need to ask why this process is if the marker marks a process, we need to ask why this process is taking place that makes sense the marker is what it is....... taking place that makes sense the marker is what it is.......a measurable substance in an organism whose presence isbiomarkersomeˌmärkər|indicative of |ˈbīō phenomenon such as disease, infection,nounor environmental exposure.a measurable aspect of anin an organism whoseof some isa measurable substance organism indicative presencebiologic processesphenomenonthe time of measurementindicative of some occuring at such as disease, infection,and can be used to track changes over time.or environmental exposure.a measurable substance in an organism whose presence isindicative of some phenomenon such as disease, infection,or environmental exposure.
  6. 6. Dynamic ProcessOccurring Across Scales of Time
  7. 7. Collective Process
  8. 8. The monkey business of Measuring process
  9. 9. Timing/context Matters Measurement and Interpretation
  10. 10. the Trees and the forest
  11. 11. Processes are flowing tides of Interconnectedness• Are Statins Diabetogenic? • Meta-Analysis, Including JUPITER Trial • Statin use Assoc. 9-13% increase in diabetes. • Summary: T2DM is Risk Equivalent for CVD, Statin use creates paradox of decreased and increased risk of CVD. Sampson UK, Linton MF, Fazio S. Are Statins Diabetogenic? Curr Opin Cardiol. 2011 Jul;26(4):342-7.
  12. 12. Quick Recap• Biomarkers Indicate Process• Look at Whole Picture• Must be Taken into Context of Your Situation• Must Integrate Markers
  13. 13. Hypercholesterolemia• Total Cholesterol: 390 (mg/dl)• LDL: 269• Triglycerides: 329• HDL: 36
  14. 14. hyperglycemia/Diabetes• Glucose: 199 (mg/dl)• HbA1c: 8.5%• Insulin: 32 (ul U/ML)
  15. 15. Hyperthyroidism/Graves?• TSH: 8.1 (uIU/ml)• Total T3: 300 (ng/dl)• Free T4: 3.2 (ng/dl)
  16. 16. Hypersomatotropism/Acromegaly• IGF-1: 641 ng/ml
  17. 17. so, What IF....• Hypercholesterolemia• Hyperthyroidism• Hyperglycemia• Hyperinsulinemia• Hypersomatotropism Puberty !
  18. 18. Part IIA Closer Look at a Few Markers
  19. 19. Survival of the Fittest? System Biomarkers
  20. 20. Journal of Obscure and Questionable Medicine (JOQM) JAMA• Conclusion: Low fitness AS important as T2DM and other CVD risk factors as a predictor of CVD mortality and all cause mortality. Clinicians should evaluate fitness in their patients just as they now obtain a medical history and measure blood pressure and cholesterol and plasma glucose levels. • Wei et al, Relationship between low cardiovascular fitness and mortality in normal-weight, overwieght, and obese men. JAMA, October 27, 1999—Vol 282, No. 16, 1547-1553.
  21. 21. NEJM• Each 1 Met INCREASE in exercise capacity conferred a 12% IMPROVEMENT in Survival• CONCLUSION: Exercise Capacity is a more powerful predictor of mortality among men than other established risk factors of cardiovascular disease.• Exercise Capacity and Mortality among Men Referred for Exercise Testing. Jonathan Myers, Ph.D., Manish Prakash, M.D.,Victor Froelicher, M.D., Dat Do, M.D., Sara Partington, B.Sc., and J. Edwin Atwood, M.D.N Engl J Med 2002; 346:793-80
  22. 22. Meta-Analysis 33 Studies; 102,000 Women and Men 33 Studies; 102,000 Women and Men• Every 1 MET VO2max Increase • 13% All-Cause Mortality Decrease • 15% CVD Mortality Decrease• “Substantial” Risk Reduction >50y.o. • VO2 > 6 Mets Women • VO2 > 8 Mets Men HR Index Predicts VO2: 6*HRindex(HRmax/HRrest) -5 = VO2 (MET’s)Kodama et al. Cardiorespiratory fitness as a Quantitative Predictor of All-Cause Mortality and Cardiovascular Events in Helathy Men and Women. JAMA, May 20, 2009—Vol301, No. 19
  23. 23. Telomeres: Health, Aging & Disease Health, Aging & Disease• Unique DN-Protein complexes that “cap and Protect DNA• May Indicate “Biologic Age”• Non-specific Marker
  24. 24. Impacting telomeres• Nutrient Levels • Omega-3, D, B-Vitamins• Stress• Weight Gain/Loss• Biomarkers • Homocysteine Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women, Am. J. Clin. Nutr. 86 (5) (2007) 1420–1425. J.B Richards, A.M. Valdes, et al. Increased telomerase activity and vitamin D supplementation in overweight African Americans, International Journal of Obesity (2011), 1 – 5 H Zhu1, Homocysteine levels and leukocyte telomere length, Atherosclerosis 200 (2) (2008) 271–277. J.B. Richards, A.M. Valdes, et al. Telomere length in peripheral blood mononuclear cells is associated with folate status in men, J. Nutr. 139 (7) (2009) 1273–1278. L. Paul, M. Cattaneo, et al. Multivitamin use and telomere length in women, Am. J. Clin. Nutr. 89 (6) (2009) 1857–1865. Q. Xu, C.G. Parks, et al. Diet, nutrition and telomere length, J. Nutr. Biochem. (2011). L. Paul
  25. 25. functional Biomarkers
  26. 26. HBA1c : Fuel Efficiency• HgbA1c for Optimal Health • 5% = 90mg/dl, 6% = 135mg/dl • AGE’s (Advanced Glycation End-Products)• Ketogenic Diets and Performance?• 50% fat, 45% Pro, 5% CHO INCREASED VO2 max and Lactate Threshold, Lowers Respiratory Exchange Ratios Lanfort et al. Effect of low carbohydrates-ketogenic diets on metabolic and hormonal responses to graded exercise tests. J Physiol Pharmacol. 1996 Jun;47(2):361-71.
  27. 27. HbA1c & Fuel Efficiency Insulin T3 IGF-I Glucose T3 thyroid hormone CR HbA1cCR caloric restriction. Turns energy acquisition to fats, see below. ATP:AMP, 10:1. Energy consumption decreases ratio, turns on PGC-1α, increasing mitochondria ATP:AMP production and efficiency FFA Rich energy yield, but less efficient rate of production. Paleo Diet promotes “fat adaption” for PGC-1α fueling. Result; your cells will be swimming in mitochondria in no time! FFA mTOR/CREP Exercise, specifically overload, turnsthis on. mTor expression correlates to muscle building. mTor STRONGEST STIMULATOR OF PGC-1α mTORGlucose: Notable Inhibitor of PGC-1α. HbA1c a reliable CREP Mitochondria indicator of average BG Biogenesis
  28. 28. fuel efficiency
  29. 29. methylation: Metabolic Efficiency
  30. 30. Hormones OS• Metabolic of us • Thyroid • Pregnenolone• Catabolic • Adrenaline • Cortisol• Anabolic
  31. 31. hormone physiology100m Olympic Swimmer Elite Crossfit Athlete 6’0”, 163 lb., 8% BF 5’9”, 210 lb., 9% BF
  32. 32. summary: Becoming superhuman• Remember Your Roots• Look at the Whole Picture • System’s Bio Analysis• Enhancement vs. Compensation• Human Potential Movement
  33. 33. Age of engagement• Measurements Matter • Adapt & Innovate• It’s Your Life; Don’t Take My Word For It. • Unique & Incomplete
  34. 34. Medimorphisys• Self Experimentation• Crowd Sourcing Solutions• Outcomes Analysis• Big Data Analytics
  35. 35. Blood, Sweat & TearsUsing Biomarkers to Become Superhuman Justin Mager, MD

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