Rearrangement to Electron Deficient Carbon <ul><li>Migratory aptitude : Ph> R, H </li></ul><ul><li>The migratory aptitude ...
Pinacole-Pinacolone Rearrangement
<ul><li>Benzilic acid rearrangement  -Diketones undergo a rearrangement when treated with hydroxide ion, giving  -hydro...
Rearrangement to Electron-deficient Nitrogen <ul><li>Hofmann rearrangement-  A carboxylic acid amide is treated with sodiu...
 
Migration to Electron-Deficient Oxygen- The Baeyer-Villiger Oxidation
 
 
 
 
 
 
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Rearrangement

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Rearrangement

  1. 1. Rearrangement to Electron Deficient Carbon <ul><li>Migratory aptitude : Ph> R, H </li></ul><ul><li>The migratory aptitude of phenyl group increases with electron donating groups </li></ul>Generation of Carbonium ion
  2. 2. Pinacole-Pinacolone Rearrangement
  3. 3. <ul><li>Benzilic acid rearrangement  -Diketones undergo a rearrangement when treated with hydroxide ion, giving  -hydroxyacids. </li></ul>
  4. 4. Rearrangement to Electron-deficient Nitrogen <ul><li>Hofmann rearrangement- A carboxylic acid amide is treated with sodium hypobromite, or bromine in alkali. The N-bromo-amide is formed and reacts with the base to give its conjugate base within which rearrangement occurs. </li></ul>
  5. 6. Migration to Electron-Deficient Oxygen- The Baeyer-Villiger Oxidation

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