Musculoskeletal group case 1

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Musculoskeletal group case 1

  1. 1. Musculoskeletal Group Case #1 4/21/08 Brian Caserto
  2. 2. Lesion Cause Relationship Pig 1 Massive/ Centrilobular Hepatic Necrosis Vit E/ Selenium Deficiency  increased free rad  oxidative necrosis Vit E- Cell membranes  Free radical scavenger Selenium  Cytosol  free radical scavenger Pig 2 Gastric Ulcer Microangiopathy Induced by Vit E Selenium def Local ischemia  infarciton  necrosis and ulceration Epicardial Hemorrhage Microangiopathy Vessel damage  hemorrhage Both Pigs Skeletal muscle necrosis and calcification Vit E Sel Def  cell membrane damage  decreased Mitochondrial ATP ER cant sequester Ca++  Hypercontraction  myofiber coagulation
  3. 3. Oxidative cell injury and necrosis Antioxidant deficiency Increased Cellular free radicals Cell membrane damage Mitochondrial membrane damage Vitamin E Vitamin E Selenium- Glutathione peroxidase Mitochondria
  4. 4. Liver Affected Tissues Blood Vessels Skeletal Muscle Necrosis Ischemia and infarction Hemorrhage Myocyte degeneration and calcification Thrombosis Necrosis
  5. 5. Vitamin E Selenium Membrane protectors Cytosol protectors Cellular Defense against oxidant injury Free Radicals: Superoxide anion Hydrogen peroxide Hydroxyl radical Glutathione peroxidase: 2GSH + H 2 O 2  -> GS–SG + 2H 2 O Glutathione reductase: GS–SG + NADPH + H +  -> 2 GSH + NADP + .
  6. 6. Vitamin E- Alpha Tocopherol Vitamin C- Ascorbic Acid
  7. 7. Iron Fe3+ + •O2− -> Fe2+ + O2 Fe2+ + H2O2 -> Fe3+ + OH− + •OH Ferric Hydroxide Dextran Free radicals from aerobic respiration <ul><li>Net overload of OH radicals </li></ul>
  8. 8. Liver: Massive to centrilobular necrosis
  9. 9. Liver: Massive to centrilobular necrosis
  10. 10. Liver: Massive to centrilobular necrosis Necrosis
  11. 11. Stomach: Gastric ulcer
  12. 12. Heart: epicardial hemorrhage
  13. 13. Heart: epicardial hemorrhage
  14. 14. Heart: Myocardial hemorrhage
  15. 15. Skeletal muscle: Necrosis and calcification Necrosis
  16. 16. Skeletal muscle: Necrosis and calcification White areas are necrotic and gritty (calcification)
  17. 17. Skeletal muscle: Necrosis and calcification Muscle fibers are disrupted and hypercellular
  18. 18. Skeletal muscle: Necrosis and calcification Calcification

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