Musculoskeletal  Pathology    Brian Caserto    March 1 2011
1.   Bovine, Mdx (3)
1.   Bovine, Mdx (3)             • Meningo(encephalo)co               ele             • Hydranencephaly             • Cran...
2.   Dog, MDx (3 possible)
2.   Mandibular Squamous cell     carcinoma, with bone lysis                      • Melanoma                      • Acanth...
3.   Dog, MDx
3. Hypertrophic             Osteodystrophy/    Metaphyseal Osteopathy
4.   Bovine, Mdx
4.   Septic ArthritisHumerus,Multifocal tocoalescing ulcerativearthritis withsubchondral bonenecrosis
5.   Dog, Mdx
5.   Humerus, Osteosarcoma
5.   Humerus, Osteosarcoma
6.   Foal            • Bone, Multifocal               necrotizing               osteomyelitis               and physitis  ...
6.   Foal      • Sequestra- large necrotic         bone separated from         blood supply      • Involucrum- Granulation...
7.   Dog, Mdx            • Spine,                intervertebral                disc                degeneration           ...
8.   Horse, Mdx
8.   Rupture of the DDF            tendon DDFTendonRupture                  Normal
9.     Rabbit, Osteofluorosis                   • Tarsus and                      metatarsus,                      diffuse ...
10.   Rabbit               • Atrophic                 rhintis               • Pasteurella                 multocida 12A   ...
11.   Pig            • Muscular              cysticerciasis            • Cysticercus              cellulosae              ...
12.   Pig  • Skeletal muscle (epaxial),      myonecrosis (rhabdomyolysis),      extensive, bilateral  • Inherited defect i...
13.   Chicken           • Tibial                Dyschondroplasia                • Osteochondrosis                • Broiler...
14.      Rhesus Monkey            • Skull, fibrous              osteodystrophy            • Vitamin D deficiency
15.   Corriedale Sheep                  • Rickets                  • Parathyroid                    hyperplasia
Corriedale Sheep
Rickets/Osteomalacia• Anything that         • Phosphorus  interferes with         deficiency-  mineralization          unco...
Rickets• Inherited errors of      • Type 2 - Vit D   Vit D metabolism           Resistant                              Ric...
Hypophosphatemic         rickets• Vit D resistant  • hypophosphatemia     (impaired renal     resorption and     intestina...
16.   Wallaby          • Mandibular            pyogranulomatous            osteomyelitis (Lumpy            Jaw)
17.   Aborted calf           • Thought this might be a             growth retardation lattice             (BVD), but histo...
18.   Bovine         • Synovial fossae in the            elbow joint, normal non-            weighbearing surfaces        ...
Bone Growth
More Bones!
Bovine DJD
DJD• Osteophyte• Enthesophyte• Synovial chondromatosis
Goat
Chicken
Crane
Bovine, calf. MDx,Associated condition
Posterior ArthrogryposisSpina bifida  cystica
Posterior ArthrogryposisSpina bifida  cystica
Terms• Spina bifida- absence of the        • Spinal dysraphism (raphe=   dorsal portions of the               suture)- term...
Arthrogryposis• AM- Arthrogryposis multiplex- Angus   cattle, AR- Front and rear legs affected• BVD/Akabane virus infectio...
Spina bifida
Spina bifida
Dog, Mdx
Palato-cheiloschisis
Fish, Disease name, Cause
Cat, Mdx, Cause
12.   Cat       • Feline            hypervitaminosis            A       • Spondylosis,            Osteoarthropathy
Cat • Feline      Osteochondromatosis • FeLV FSV particles • Affects long bones as      well as      intramembranous      ...
Dog uap
Dog
Foal
Chicken    • Rickets     •Similar to     osteochondrosis     •Cysts often present     in long standing cases
Chicken
Nutritional DisordersRickets (bending of the tibiotarsus, distortion of the ribs and enlargement of the costocondral junct...
Slipped Gastrocnemius        Tendon
Bovine
Layer chicken        •   Cage Layer Fatigue            •   Osteoporosis-fractures                of limbs, with           ...
Cage Layer Fatigue
Horse
Bovine
Osteopetrosis
Horse
Ox
Bovine
OX
Ox
Ox, Associated finding
Ox
Ox, Pathogenesis
Dog
Dog
Horse
Horse
Cynomolgus Monkey
Rhesus Monkey,Condition, Cause
Squirrel Monkey
European Pond turtle
Monitor Lizard
Cane toad
Iguana
Goat
Suffolk Sheep
Hereditarychondrodysplasia       •   Multiple irregular ossification           centers in long bones- hypertrophic         ...
Sheep
Holoprosencephaly• Failure of the rostral   • V.   cerebrum to divide        californicum-   normally                  ant...
Caribou
Deer
Sea Lion
Elk
Dog
ArthritisActinobacillus suis (Pig),                             E coli (All), Erysipelas, Strep, Haemophilus, Mycoplasma  ...
Bovine Fluoride Toxicity
Bovine Lymphoma
Camel
Dog
Horse
Dog, MCE
Sheep
Elk
WT DEER
Pig
Hole in the Head disease
Foal
Horse
Foal
Osteogenesis imperfecta     presumptive
OGIMp Presumed
Alpaca Osteomyelitis
Horse
Aborted bovine calf
Bovine, Synovial fossa      (normal)
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Bone rounds 3 1-11
Upcoming SlideShare
Loading in …5
×

Bone rounds 3 1-11

1,803 views

Published on

0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total views
1,803
On SlideShare
0
From Embeds
0
Number of Embeds
3
Actions
Shares
0
Downloads
0
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

Bone rounds 3 1-11

  1. 1. Musculoskeletal Pathology Brian Caserto March 1 2011
  2. 2. 1. Bovine, Mdx (3)
  3. 3. 1. Bovine, Mdx (3) • Meningo(encephalo)co ele • Hydranencephaly • Crania bifida/ Craniaschisis
  4. 4. 2. Dog, MDx (3 possible)
  5. 5. 2. Mandibular Squamous cell carcinoma, with bone lysis • Melanoma • Acanthomatous epulis • Fibromatous epulis of periodontal ligament origin • Gingival hyperplasia
  6. 6. 3. Dog, MDx
  7. 7. 3. Hypertrophic Osteodystrophy/ Metaphyseal Osteopathy
  8. 8. 4. Bovine, Mdx
  9. 9. 4. Septic ArthritisHumerus,Multifocal tocoalescing ulcerativearthritis withsubchondral bonenecrosis
  10. 10. 5. Dog, Mdx
  11. 11. 5. Humerus, Osteosarcoma
  12. 12. 5. Humerus, Osteosarcoma
  13. 13. 6. Foal • Bone, Multifocal necrotizing osteomyelitis and physitis with sequestra • E coli, Strep spp, Salmonella, Klebsiella, Rhodococcus equi,Arcanobact erium pyogenes, Actinobacillus equuli
  14. 14. 6. Foal • Sequestra- large necrotic bone separated from blood supply • Involucrum- Granulation tissue or reactivebone around the sequestra • Foals most commonly in secondary ossification centers, and can cause articular cartilage defects
  15. 15. 7. Dog, Mdx • Spine, intervertebral disc degeneration and prolapse with spinal cord compression • Vertebral osteosclerosis
  16. 16. 8. Horse, Mdx
  17. 17. 8. Rupture of the DDF tendon DDFTendonRupture Normal
  18. 18. 9. Rabbit, Osteofluorosis • Tarsus and metatarsus, diffuse periosteal hyperostosis • Caused by fluoride toxicity • Accompanied by gastric mucosal hyperplasia • Histo Periosetal and endosteal hyperostosis
  19. 19. 10. Rabbit • Atrophic rhintis • Pasteurella multocida 12A • Bronchopneum onia, otitis media
  20. 20. 11. Pig • Muscular cysticerciasis • Cysticercus cellulosae (taenia solium) • Measly pork
  21. 21. 12. Pig • Skeletal muscle (epaxial), myonecrosis (rhabdomyolysis), extensive, bilateral • Inherited defect in the Ryanodine receptor --> uncontrolled increase in sarcoplasmic calcium --> prolonged muscle contraction -- > acute rhabdomyolsis
  22. 22. 13. Chicken • Tibial Dyschondroplasia • Osteochondrosis • Broiler chickens • Rapid growth diets • Genetics • High Phosphorus to calcium ratio • Fusarium roseum
  23. 23. 14. Rhesus Monkey • Skull, fibrous osteodystrophy • Vitamin D deficiency
  24. 24. 15. Corriedale Sheep • Rickets • Parathyroid hyperplasia
  25. 25. Corriedale Sheep
  26. 26. Rickets/Osteomalacia• Anything that • Phosphorus interferes with deficiency- mineralization uncommon (Cattle >Sheep > • Vit D Deficiency- Horses) Sunlight, ingested , • Calcium depressed by deficiency- carotenoids rapidly corrected serum calcium not likely to be cause of faulty mineralization
  27. 27. Rickets• Inherited errors of • Type 2 - Vit D Vit D metabolism Resistant Rickets- Defect in • Type 1- Vit D 1,25 Dependent dihydroxycholeca Rickets- defect in lciferol receptor renal alpha-1- hydroxylase • cant use D2, and D3 is • treat with present in 1,25 (OH)2 D3 high amounts without hypercalcemi
  28. 28. Hypophosphatemic rickets• Vit D resistant • hypophosphatemia (impaired renal resorption and intestinal absorption), normocalcemia, skeletal deformities • Plasma 1,25 Dihydroxy D3 levels are low
  29. 29. 16. Wallaby • Mandibular pyogranulomatous osteomyelitis (Lumpy Jaw)
  30. 30. 17. Aborted calf • Thought this might be a growth retardation lattice (BVD), but histolgically normal primary and secondary spongiosa with local band of reduced hematopoiesis
  31. 31. 18. Bovine • Synovial fossae in the elbow joint, normal non- weighbearing surfaces develop as a consequence of joint modeling • found in horses, cows, and pigs
  32. 32. Bone Growth
  33. 33. More Bones!
  34. 34. Bovine DJD
  35. 35. DJD• Osteophyte• Enthesophyte• Synovial chondromatosis
  36. 36. Goat
  37. 37. Chicken
  38. 38. Crane
  39. 39. Bovine, calf. MDx,Associated condition
  40. 40. Posterior ArthrogryposisSpina bifida cystica
  41. 41. Posterior ArthrogryposisSpina bifida cystica
  42. 42. Terms• Spina bifida- absence of the • Spinal dysraphism (raphe= dorsal portions of the suture)- term applies to the vertebrae (secondary to neural tube- Applies to spinal failure of the neural tube to cord and may have vertebral close completely) abnormalities • occulta- skin overlying • Myeloshisis (“marrow”= the defect is normal, and fatty=spinal cord/bone spinal cord may be grossly marrow+ cleft)-same as normal dysraphism • cystica- a cystic swelling • Dermoid sinus- congenital in protrudes through the Rhodesian ridgebacks- vertebral defect incomplete separation of the neural tube from the overlying • Meningomyelocele- dorsal midline ectoderm spinal cord is missing segments
  43. 43. Arthrogryposis• AM- Arthrogryposis multiplex- Angus cattle, AR- Front and rear legs affected• BVD/Akabane virus infection in utero• Toxic- Lupins (crooked calf disease), Veratrum californicum (day 29 gestation), Conium maculatum (pigs, cows), Jimsonweed, Wild black cherry, locoweed (Astragalus and Oxytropis), Hybrid sorghum and Sudan grass in foals
  44. 44. Spina bifida
  45. 45. Spina bifida
  46. 46. Dog, Mdx
  47. 47. Palato-cheiloschisis
  48. 48. Fish, Disease name, Cause
  49. 49. Cat, Mdx, Cause
  50. 50. 12. Cat • Feline hypervitaminosis A • Spondylosis, Osteoarthropathy
  51. 51. Cat • Feline Osteochondromatosis • FeLV FSV particles • Affects long bones as well as intramembranous bones
  52. 52. Dog uap
  53. 53. Dog
  54. 54. Foal
  55. 55. Chicken • Rickets •Similar to osteochondrosis •Cysts often present in long standing cases
  56. 56. Chicken
  57. 57. Nutritional DisordersRickets (bending of the tibiotarsus, distortion of the ribs and enlargement of the costocondral junctions)Manganese deficiency Tibial chondrodystrophy, displacement of gastrocnemius tendon (Perosis)Riboflavin (B2) deficiency  Curly toe paralysisNutritional Etiology• Calcium or phosphorus deficiency or an imbalance in these nutrients will result in rickets in immature birds or osteomalacia in mature breeders and commercial egg-production flocks.• Vitamin D3 (cholecalciferol) deficiency results in rickets in immature flocks housed in controlled environment units.• Thiamine (vitamin B1) deficiency results in an abnormal gait progressing to recumbency and paralysis with hyperextension of the neck.• Riboflavin (vitamin B2) deficiency results in a deformity of the feet termed “curled toe paralysis”.• Pyridoxine (vitamin B6) deficiency results in abnormal gait and convulsions. This condition can also occur following administration of toxic levels of nitrofurans to immature flocks.• Manganese deficiency results in chondrodystrophy. This occurs in growing chicks due to decreased formation of bone below the growth plates of the tibiotarsus and tarsometatarsus. Mildly affected chickens show stunting and enlargement of the hock joint with reduction in the length of the leg bones. The lesion progresses to severe deformation of the hock joint culminating in displacement of the gastrocnemius (Achilles) tendon (perosis). Chondrodystrophy is characterized by a high prevalence in the flock, bilateral involvement of the hock joints and reduction in length of the long bones. Confirmation of the diagnosis requires analysis of feed to determine manganese content. Dietary level should range from 80 to 120 ppm for optimal growth.• Choline and pyridoxine deficiency may result in bilateral enlargement of hock joints, sometimes with displacement of the gastrocnemius tendon.• Chondrodystrophy should be differentiated from valgus-varus abnormality of genetic origin.
  58. 58. Slipped Gastrocnemius Tendon
  59. 59. Bovine
  60. 60. Layer chicken • Cage Layer Fatigue • Osteoporosis-fractures of limbs, with osteomalacia histologically • Muscle weakness also a feature • Occurs in animals in cages, but resolves if on the ground • Relative calcium deficiency (below 2:1 ratio)
  61. 61. Cage Layer Fatigue
  62. 62. Horse
  63. 63. Bovine
  64. 64. Osteopetrosis
  65. 65. Horse
  66. 66. Ox
  67. 67. Bovine
  68. 68. OX
  69. 69. Ox
  70. 70. Ox, Associated finding
  71. 71. Ox
  72. 72. Ox, Pathogenesis
  73. 73. Dog
  74. 74. Dog
  75. 75. Horse
  76. 76. Horse
  77. 77. Cynomolgus Monkey
  78. 78. Rhesus Monkey,Condition, Cause
  79. 79. Squirrel Monkey
  80. 80. European Pond turtle
  81. 81. Monitor Lizard
  82. 82. Cane toad
  83. 83. Iguana
  84. 84. Goat
  85. 85. Suffolk Sheep
  86. 86. Hereditarychondrodysplasia • Multiple irregular ossification centers in long bones- hypertrophic cartilage forms nodules thatf ail to develop normally, lack of subchondral bone predisposes to degenerative arthropathy- bone growth in utero is normal • Suffolk and Hampshire sheep • Long limbs, necks, kyphosis/ scoliosis, sternal deformity, valgus deformities below the carpus, roman nose, deviated nasal septum, shortening of maxilla, elongation of the occipital condyles- affects all endochondral bones and
  87. 87. Sheep
  88. 88. Holoprosencephaly• Failure of the rostral • V. cerebrum to divide californicum- normally antagonism of sonic • Arhinencephaly- hedgehog aplasia of the gene- involves olfactory bulbs the rostral and tracts extremity of the notochord • craniofacial and the abnormalities- surrouding cyclopia mesenchyme (synophthalmus)
  89. 89. Caribou
  90. 90. Deer
  91. 91. Sea Lion
  92. 92. Elk
  93. 93. Dog
  94. 94. ArthritisActinobacillus suis (Pig), E coli (All), Erysipelas, Strep, Haemophilus, Mycoplasma Arcanobacterium hyorhinis (pig), Mycoplasma (ox) pyogenes (Ox)
  95. 95. Bovine Fluoride Toxicity
  96. 96. Bovine Lymphoma
  97. 97. Camel
  98. 98. Dog
  99. 99. Horse
  100. 100. Dog, MCE
  101. 101. Sheep
  102. 102. Elk
  103. 103. WT DEER
  104. 104. Pig
  105. 105. Hole in the Head disease
  106. 106. Foal
  107. 107. Horse
  108. 108. Foal
  109. 109. Osteogenesis imperfecta presumptive
  110. 110. OGIMp Presumed
  111. 111. Alpaca Osteomyelitis
  112. 112. Horse
  113. 113. Aborted bovine calf
  114. 114. Bovine, Synovial fossa (normal)

×