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Peptic ulcer – an infectious disease!This years Nobel Prize in Physiology or Medicine goes to Barry Marshall and RobinWarren, who with tenacity and a prepared mind challenged prevailing dogmas. Byusing technologies generally available (fibre endoscopy, silver staining ofhistological sections and culture techniques for microaerophilic bacteria), theymade an irrefutable case that the bacterium Helicobacter pylori is causing disease.By culturing the bacteria they made them amenable to scientific study.In 1982, when this bacterium was discovered by Marshall and Warren, stress andlifestyle were considered the major causes of peptic ulcer disease. It is nowfirmly established that Helicobacter pyloricauses more then 90% of duodenal ulcers.The link between Helicobacter pyloriinfection and peptic ulcer disease has beenestablished through studies of humanvolunteers, antibiotic treatment studies andepidemiological studies.
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