Skeletal muscle relaxants uses and side effects

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Skeletal muscle relaxants uses and side effects

  1. 1. Skeletal Muscle Relaxants Uses, Efficacy, and Side Effects Skeletal muscle relaxants are a heterogeneous group of medications. As a class, they are structurally and pharmacologically diverse. Muscle relaxants are used to treat two different types of underlying conditions: spasticity from upper motor neuron syndromes muscular pain or spasms from peripheral musculoskeletal conditions Although muscle relaxants have by convention been classified into onegroup, the Food and Drug Administration (FDA) has approved only a fewmedications in this class for treatment of spasticity. The remainder are approvedfor treatment of musculoskeletal conditions. Best best skeletal muscle relaxant - Skelaxin (Metaxalone) Buy Skelaxin Online at http://skelaxinonline.net Muscle relaxants for treatment of spasticity Spasticity is a state of increased muscular tone with exaggeration of thetendon reflexes. Some of the more common conditions associated withspasticity and requiring treatment include multiple sclerosis, spinal cord injury,traumatic brain injury, cerebral palsy, and poststroke syndrome. In manypatients with these conditions, spasticity can be disabling and painful with amarked effect on functional ability and quality of life. The upper motor neuron syndrome is a complex of signs and symptomsthat can be associated with exaggerated cutaneous reflexes, autonomichyperreflexia, dystonia, contractures, paresis, lack of dexterity, and fatigability.Spasticity from the upper motor neuron syndrome can result from a variety ofconditions affecting the cortex or spinal cord. Muscle relaxants for treatment of musculoskeletal conditions Muscle spasm is defined as a sudden involuntary contraction of one ormore muscle groups and is usually an acute condition associated with muscle
  2. 2. strain (partial tear of a muscle) or sprain (partial or complete rupture of aligament). Common musculoskeletal conditions causing tenderness and musclespasms include fibromyalgia, tension headaches, myofascial pain syndrome,and mechanical low back pain or neck pain. If muscle spasm is present in theseconditions, it is related to local factors involving the affected muscle groups. Efficacy Most studies have shown the skeletal muscle relaxants to be moreeffective than placebo in the treatment of acute painful musculoskeletaldisorders and muscle spasm, while efficacy was less consistent when treatingchronic disorders. When muscle relaxants were used alone, they were notconsistently superior to simple analgesics in relieving pain. When the skeletalmuscle relaxants were used in combination with analgesics, pain relief is superiorto either agent used alone. Studies have suggested that these drugs areeffective, have tolerable side effects, and can be an adjunct in the treatmentof painful musculoskeletal conditions with associated muscle spasm. No studies have documented superior efficacy of one skeletal musclerelaxant over another. SideEffectsandAdversereactions All skeletal muscle relaxants may cause sedation (drowsiness, dizziness). Also they can cause severe central nervous system depression with cardiovascular collapse and respiratory failure. Some have a potential for hepatotoxicity. Overt hepatitis has been most frequently observed between the third and twelfth months of therapy. Risk of hepatic injury appears to be greater in women, in patients over 35 years of age and in patients taking other medications. Some of them have potential for dependence and withdrawal symptoms. Also may have some toxicity in overdose and in combination with other substances. Some of them may cause low blood pressure, but this may be controlled by starting with a low dose and increasing it gradually. The drug may rarely cause liver damage. Causes harmless color changes in urine - orange or reddish-purple. The urine will return to its normal color when the patient stops taking the medicine. Please follow this link if you would like to read more about muscle relaxantSkelaxin - http://skelaxinonline.net

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