RECENT ADVANCES IN
VIGNAN ISTITUTE OF PHARMACEUTICAL TECHNOLOGY
ADVANCES IN BIOTECHNOLOGY
3.Cancer spit test
The new bio-absorbable stent , which can dissolve
completely after some 18-odd months in the blood vessel , is
set to revolutionize the treatment of cardiac problems in
Angioplasty and stenting are usually done through a small
puncture, or sometimes a small incision, in your skin, called
the access site.
Your vascular surgeon inserts a long, thin tube called a
catheter through this access site.
Using X-ray guidance, your physician then guides the
catheter through your blood vessels to the blocked area
The tip of the catheter carries the angioplasty balloon or
Doctors at the National University Heart
Centre, Singapore (NUHCS) started using
the new stent from February 2011 as part
of a global clinical trial that is still on
More than 600 patients have taken part
in the trial, which aims to have 1,000
patients from up to 100 centres in
Europe, the Asia-Pacific, Canada and
It will cost Rs 2.85 to 3 lakh for each stent ,
and the entire hospitalization may cost a
patient over Rs 4 lakh for a single stent
New discovery gives hope that nerves could be repaired after
spinal cord injury
Researchers from Imperial College London and the Hertie
Institute, University of Tuebingen have identified a possible
mechanism for re-growing damaged nerve fibres in the
central nervous system (CNS).
The research highlights the role of a protein called
P300/CBP-associated factor (PCAF), which appears to be
essential for the series of chemical and genetic events that
allow nerves to regenerate.
A Nano gel developed at Northwestern University eliminates
Injected as a liquid, the Nano gel self-assembles into a
scaffold of nanofibers.
Peptides expressed in the fibers instruct stem cells that
would normally form scar tissue to produce cells that
encourage nerve development.
CANCER SPIT TEST
Researchers at Johns Hopkins led a proof-of-principle study
that successfully identified tumor DNA shed into the blood
and saliva of 93 patients with head and neck cancer.
Detection of somatic mutations and HPV in the saliva and
plasma of patients with head and neck squamous cell
Blood tests appeared to find more cancers in the larynx,
hypopharynx, and oropharynx.
Inborn genetic predispositions for most head and neck
cancers are rare, but other mutations that don't generally
occur in normal cells have long been considered good targets
for screening tests
The scientists detected tumor DNA in the saliva of 71 of the
93 patients (76%) and in the blood of 41 of the 47 (87%).
saliva tests fared better than blood tests for oral cavity cancers.
ADVANCES IN PHARMACEUTICAL
1. Nano cosmeceuticals
2. Topical delivery system for phytochemicals
Liposomes are used in a variety of cosmeceuticals
because they are biocompatible, biodegradable, nontoxic,
and flexible vesicles and can encapsulate active ingredients
Silver nanoparticles are used in cosmeceuticals
for their antimicrobial activity.
Cosmeceuticals infer products with more advance function
through combination of cosmetics and pharmaceuticals.
Cosmeceuticals can benefit greatly from nanotechnology
when Nano-sized TiO2 administered subcutaneously to
pregnant mice, they transferred to the offspring and result
in brain damage and reduced sperm production in male
Oro Gold Cosmetics, whose products cost as much as $1,398 for a
face mask, includes gold nanoparticles in its formulas and claims that
these nanoparticles have anti-inflammatory and antioxidant
properties, drive tissue regeneration, restore skin elasticity, and
reduce signs of stress and aging
Top FIVE nanotechnology cosmetic products in the world
The most popular nanomaterials used in sunscreens are
Nano particulate Zinc oxide (ZnO) and Titanium dioxide
Lancôme and Dior have leading sunscreen products that
The most widely used nanomaterials are Liposomes, Nano-
emulsions and solid lipid nanoparticles.
Lancôme and Nano-Infinity Nanotech are two cosmetic
companies which produce skin moisturizers
The most popular brand in nanotechnology antiwrinkle
products is L'Oréal, which markets an antiwrinkle cream
named Ravtalift which contains nanosomes with Pro-retinol
A; a modified version of vitamin A specially designed to
deliver the nutrient to cells
Lancôme also markets a moisturizing antiwrinkle product by
the name of Hydra Zen cream which contains nutrients
encapsulated in a Nano sized particle.
Especially Nano emulsions is emerging as a great method of
delivering hair cosmetics to the inner structure of the hair
fiber without damaging outer shell called cuticle due to their
small size. Another very active area of nanotechnology hair
care is sericin nanoparticles, primarily as a sealing agent for
damaged hair to treat damaged cuticles.
Nanoemulsions and antibacterial nanoparticles have been
used to prepare nanotechnology based cosmeceuticals that
can provide better cleansing effects
TOPICAL DELIVERY SYSTEM FOR PHYTOCHEMICALS
phytochemicals suffer from limited bioavailability and their full
potentials as medicine remains hampered by their physicochemical
Capsaicinoids, acid amides of vanyllylamine and C9-C11
branched chain fatty acids, are alkaloids present in Capsicum
The two major capsaicinoids present in the most varieties of
Capsicum fruit are capsaicin and dihydrocapsaicin, which
make up more than 91% of the total capsaicinoids.
Carbopol gels are prepared using liposome or ethosome
suspensions which are used topically.
The incorporation of capsaicin into phospholipid vesicles is
expected to increase its skin penetration, resulting in
increased localized effect even at lower doses as compared
with conventional creams and ointments.
Capsicum tincture was prepared according to Japanese
Liposomes were prepared by the modified film method and
ethosomes are also prepared
ADVANCES IN PHARMACOLOGY
1. Anti-Parkinson Activity of Petroleum Ether Extract of
Ficus religiosa (L.) Leaves
Parkinson’s disease (PD) is caused by the gradual and
selective loss of dopaminergic neurons in the substantia nigra
Oxidative stress interferes with dopamine metabolism
leading to Parkinson’s disease.
The current available drug treatments for PD possess various
herbal therapies should be considered as
alternative/complementary medicines for therapeutic
Anti-Parkinson Activity of Petroleum Ether Extract of Ficus
religiosa (L.) Leaves
Fresh leaves of Ficus religiosa were collected from local area
of Ahmedabad district, Gujarat, India, during July–
Adult male Wistar rats, weighing 180–220 g, and albino mice
of either sex weighing 25–30 g were used and acclimatized
to laboratory condition for one week.
Coarsely powdered plant material (1000 g) was weighed and
extracted with 5 lit of solvents like petroleum ether (60–
80°C), ethyl acetate, and ethanol by successive extraction in
a Soxhlet apparatus for 72 h.
Treatment with F. religiosa significantly reduced the
catalepsy in haloperidol treated rats in dose dependent
Haloperidol, an antipsychotic drug, blocks central dopamine
receptor in striatum