Introduction to basic principles of pharmacology

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Introduction to basic principles of pharmacology

  1. 1. Introduction to Basic Principles of Pharmacology<br />By<br />BalmukundThakkar<br />1<br />
  2. 2. Contents<br />What is pharmacology?<br />Pharmacodynamics<br />Pharmacokinetics<br />Bioassays and Clinical Trials<br />Summary<br />2<br />
  3. 3. What is Pharmacology ?<br />3<br />
  4. 4. What is Pharmacology? <br />4<br />In simple words, “Study of the effects of drugs on the function of living systems”<br />Drug: a chemical substance of known structure, which, when administered to a living organism, produces a biological effect.<br />
  5. 5. Pharmacology<br />5<br />
  6. 6. Pharmacodynamics<br />6<br />
  7. 7. How drugs act…<br />7<br />Pharmacodynamics<br />In Simple words, “Study of howdrugs act on living body”<br />General principles <br />Molecular aspects<br />Cellular aspects<br />
  8. 8. How Drugs Act: General Principles<br />8<br /><ul><li>The Binding Postulate
  9. 9. Paul Ehrlich: “Corpora non agunt nisi fixata” i.e. </li></ul> 'A drug will not work unless it is bound’<br />
  10. 10. 9<br />Drug targets<br />
  11. 11. Receptors<br /><ul><li>The cellular assembly which recognizes one or more chemical mediators</li></ul>Affinity<br />Efficacy<br />10<br />
  12. 12. 11<br />Agonists, Partial agonists and Antagonists<br />
  13. 13. 12<br />Antagonism<br />
  14. 14. 13<br />How Drugs Act: Molecular Aspects<br />
  15. 15. How Drugs Act: Molecular Aspects<br />14<br />
  16. 16. Pharmacokinetics<br />15<br />
  17. 17. 16<br />Pharmacokinetics<br />Bioavailability<br />
  18. 18. 17<br />ADME<br />
  19. 19. 18<br />Important factors affecting oral bioavailability<br />
  20. 20. Distribution<br />19<br />
  21. 21. 20<br />Important factors affecting<br />distribution<br />
  22. 22. 21<br />Metabolism<br />
  23. 23. 22<br />Phase-1 Metabolism<br />
  24. 24. 23<br />Phase-2 Metabolism<br />
  25. 25. 24<br />Excretion<br />
  26. 26. 25<br />Pharmacokinetic Curve<br />
  27. 27. 26<br />Bioassays and Clinical Trials<br />
  28. 28. 27<br />Dose Response Curve<br />
  29. 29. 28<br />Bioassay parameters<br />
  30. 30. Bioassay parameters<br />29<br />
  31. 31. 30<br />Drug Trials<br />
  32. 32. 31<br />Clinical Trials<br />
  33. 33. 32<br />Summary<br />
  34. 34. Summary<br />Pharmacology : It’s all about drugs<br />Highly interdisciplinary applied science<br />Different subdivisions – In overall, core of drug discovery<br />One of the most important divisions of pharmaceutical sciences<br />33<br />
  35. 35. References<br />Rang and Dale’s Pharmacology, 6th Ed., Churchill Livingstone, London, 2007<br />Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11th Ed., Mcgraw-hill Medical Publishing Division, New York, 2006<br />en.wikipedia.org<br />34<br />
  36. 36. 35<br /><br /><br />

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