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Babbileo pp kylie-b,stephanien


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Babbileo pp kylie-b,stephanien

  2. 2. Background information• Species name:Vitexnegundo• Common name:Lagundi or Chastetree• Family: Lamiaceae• Native to: SoutheastAsia, and Eastern andSouthern Africa
  3. 3. Background informationThree varieties exist:• var. incisa• var. cannabifolia• var. negundo
  4. 4. Identification of lagundi• Height: up to 5 meters• Single woody stem• Five pointed leafs, in leaflet structure• Blue and lavender flowers;• Usually found in swampy areas
  5. 5. Beneficial Uses• Asthma relief• Anti-inflammatory (swelling due to injury, headaches, etc.)• Anti-oxidant (general health)• Anti-histamine (reduces allergies)
  6. 6. Current research• Has been clinically tested to treat: colds, flus, bronchialasthma, chronic bronchitis• The Department of Health in the Phillipines is currentlyconducting research on the lagundi• They hypothesize that lagundi mayhave some therapeutic benefits
  7. 7. What is an anti-histamine?• What is histamine?• Involved in local immune responses• Response to a signal from IgE antibodies on the surface of mastcells• These mast cells then release histamine• Leads to vasodilation, causing symptoms such as sneezing, runnynose, itchy eyes• Anti-histamines are competitive inhibitors: they block thebinding of histamine to a cell surface receptor, thus nosymptoms occur
  8. 8. Steps in the Histamine PathwayStep 1: Allergen is encounteredStep 2: Allergen is detected by white blood cells, the cells thenproduce specific IgE antibodiesStep 3: IgE antibodies attach to the surface of mast cellsStep 4: Allergen attaches to antibodies on mast cell, histamine isreleasedStep 5: Histamine is recognized by cell surface receptorsStep 6: Symptoms arise
  9. 9. Step 1• Some allergens areairborne• Others can be ingestedthrough food• Allergies can beacquired early or late inlifeAllergen enters the body
  10. 10. Step 2White blood cells recognizeallergens as harmfulThis causes whiteblood cells to releaseIgE antibodies
  11. 11. Step 3IgE antibodies attach tothe surface of mast cells
  12. 12. Step 4• Allergens can then berecognized by the IgEantibodies• This causes therelease of histamine bythe mast cell
  13. 13. Step 5Histamine then binds tocell surface receptorson epithelial cells thatline blood vessels andcapillaries throughoutthe body
  14. 14. Step 6Binding of the histamine tocell surface receptorscauses a chain of eventsThis leads tovasodilation, causingthe release ofexcess fluidsThis leads toallergenic symptoms
  15. 15. Anti-histamine Function• Anti-histamines blockthe binding ofhistamine to cellsurface receptors• Thus, vasodilationdoes not occur andsymptoms are reducedor eliminated
  16. 16. How does Vitexnegundo work?• The leaves are boiled and the broth is consumed• It produces the compound chrysoplenolD, which has anti-histamine properties• These anti-histamine molecules compete with histamineto reduce allergic reactions and symptoms• Modern medicine has allowed the creation of capsule andliquid forms of this therapy