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Bag-on-Valve SystemsCreating BarriersOnce a tiny niche of the aerosol market, more and more                               ...
Gels can also be packaged using BoV,            99 per cent, and once the product is used                 the product, the...
Although the gases used in BoV Benefits of BoV                                                                            ...
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Bag-On-Valve | The Benefits of BOV Spray Technology


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Learn about the benefits and uses of Bag-On-Valve spray technology.

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Bag-On-Valve | The Benefits of BOV Spray Technology

  1. 1. Bag-on-Valve SystemsCreating BarriersOnce a tiny niche of the aerosol market, more and more Magnus Hedman atcompanies are turning to Bag-on-Valve (BoV) aerosols to Aurena Laboratories ABpackage their products. BoV is an ideal barrier packagefor liquids, gels, creams and lotions, keeping high productintegrity and protection against oxygen exposureIn the pharma industry, there is an Figure 1: Components forincreased interest in giving old products BoV with an opened cannew, more convenient applications,as well as finding niches for totallynew products using Bag-on-Valve(BoV) technology for packaging andadministration. Applications now coversaline/seawater nasal sprays, woundcleansing/irrigation sprays, eyewashsprays, dermal drug delivery products,disinfectant sprays and veterinaryproducts, among others. There is aslow but growing consumer awarenessregarding BoV products. Global volumesincrease from year to year, replacingtypical pump and dispensing sprays aswell as traditional aerosols.Diverse Range of ApplicationsWith its many dispensing possibilities,BoV is suitable for direct dispensing, evenin such sensitive areas as eyes or ears orwith children. After an eye accident, forinstance, it is very important to rinse theeye in the first seconds. BoV portable eye Images: Aurena Laboratories ABwash spray makes a good choice whena piped eye wash station is not available.With a 240ml can, equipped with a sprayactuator giving a very soft spray, it is nowpossible to flush the eye constantly formore than 15 minutes. how long or how often they are used, available for nasal application. In the ear,Wound washing spray must be kept they are safe for everyone. The saline nose and throat segment there are alsototally sterile during its entire shelf-life, nasal sprays are classified as medical BoV products on the market that help towhich is possible for many BoV products. devices in the EU and can either replace prevent build-up of earwax.The spray works at any angle, reduces or complement the use of drug-classifiedpathogens, removes foreign bodies as nasal sprays. Emollient sprays protect the skin fromwell as blood, clot and dead tissue, and minor irritation and soreness and createmoistens the tissue in the process. Another upcoming area currently a barrier that protects irritated skin from catching interest is that of throat sprays, damage caused by urine and faeces, forVarious nasal sprays are among the most with the aim of soothing and preventing instance. Unlike applying an emollient aspopular BoV products on the over-the- sore throat symptoms during colds a cream and rubbing it onto the skin, ancounter market. Usually based on sterile and allergies. It is possible that we will emollient spray is contact-free, meaning itsaline solutions, they soothe and relieve soon see a similar range of throat spray can be administered without risk ofstuffy noses and sinus pressure. No matter products on the market as is already cross-contamination.62 February 2013
  2. 2. Gels can also be packaged using BoV, 99 per cent, and once the product is used the product, they guarantee its integritysuch as burn gel sprays for treating burns, up and empty, it does not contain any and are not released into the atmosphere.scalds and sunburns. Creams and foams flammable residual of propellant.are also suitable solutions to be packaged As the BoV does not use any flammablein a BoV system, as are alcohol-based Non-Flammable Propellants propellant, it can be classified as ahand sanitisers. The most common replacements for the non-flammable aerosol, providing the chlorofluorocarbons, which were used solution itself does not contain flammableTotal Integrity and Sterility as aerosol propellants before they were ingredients. The non-flammableTaking a look at some of the general banned by the Montreal Protocol in 1989, classification offers obvious advantagesbenefits of BoV packaged products are mixtures of volatile hydrocarbons, regarding safety, transportation andcompared to alternative packaging typically propane, n-butane and, there are a few particularly isobutane. Dimethyl ether and methylstriking features. First of all, there is the ethyl ether are also used. All these have The foil-based packaging used in a BoVobvious advantage of total integrity and the disadvantage of being flammable. system typically consists of four-layersterility that BoV offers the product sealed aluminium film laminates, for instanceinside the bag. The product will not only Manual pump sprays can be used as polyester, aluminium, polyamide andbe kept sterile until it is used for the first an alternative to a stored propellant. polpypropylen (PET/ALU/OPA/PP), whichtime, but will remain sterile during the However, these do have the guarantee impermeability. The filmproduct’s entire shelf-life. disadvantages of requiring hand power, laminate bag is welded to the aerosol valve, not providing an even, continuous which is crimped to the aerosol can in theThen there are the many conveniences dispensing, and normally the inability to filling process. BoV typically uses standardfor the end users of the products, whether use the product at any angle. aerosol cans with one-inch can openings.they are healthcare professionals orconsumers purchasing the products over The propellants of BoV products, on the When the valve is crimped to the can,the counter. The fact that they can be other hand, are compressed air or nitrogen, the compressed gas is also filled into theused at any angle is a great advantage neither of which are flammable or area between the bag and the can. Thiscompared to hand-pumps or tubes, for hazardous to the environment. Since they pressurising process is called under theinstance, as is the continuous dispensing are contained between the bag and the cup gassing. The process creates an initialof the products, making them easy to use can, and they never come into contact with pressure of a few bars in the can.– even in emergency situations. Figure 2: BoV TechnologyContact-free dispensing gives advantagesin hygiene and patient integrity. Since theproducts can be applied without actually The Valve 1touching the skin, avoiding the spread of BoV systems arecontamination from the hands, they are available with bothideal for sensitive product applications. female and male valves 6 The ActuatorFor healthcare professionals and patients A wide range ofalike, it is less encumbering having standard actuators are The Bag 2 available, depending onsomeone spray rather than rub the FDA-approved product demandscontent onto the skin. laminated bag (three or four layers depending on productIf desired, a BoV aerosol can produce a requirements). Available 5 The Cansmooth and even layer of a film-forming in a wide range of sizes Standard aerosol can,product or a protective barrier cream aluminium or tinplate. All sorts of shapedto the skin. Examples include silicone- The Product 3 cans can be used. Nobased barrier films used for treating dry, limitation in marketing Suitable for liquidsensitive skin. Oxygen-sensitive actives as well as viscous solutionslike probiotics and omega-3 oils are also products, such assuitable for packaging in BoV systems, gels, creams and ointments, in a numbereven if the commercial products have yet 4 The Propellant of application reach the consumer market. Optimised for oxygen- Because of the sensitive and sterile separation between products product and propellant,Compared to traditional aerosol products BoV can be used withwhere the propellant is part of the compressed air or nitrogenformula, products dispensed through BoVhave no chilling effect. Product evacuation The Capfor a BoV product ranges between 95 and Can be used with many kinds of standard overcaps64
  3. 3. Although the gases used in BoV Benefits of BoV products are totally harmless, the products are still classified as aerosols BoV offers major advantages for a range of • Even and controlled spraying pattern (UN 1950). Depending on the local aerosol products where safe and contact- for optimal result regulations for aerosols, recycling of free dispensing is required. BoV gives new • No pumping motion needed BoV products are handled differently in marketing opportunities through improved • Can be used at all angles different states or countries. However, consumer conveniences, product protection • Reduced spray noise and controlled discharge of the product. • Less chilling product discharge they usually fit into the recycling programmes of most countries. Safety and Environmental Benefits Production and Distribution Benefits Aluminium has a high recycling value • No need for flammable propellants • Longer shelf-life for oxygen-sensitive and can be recycled many times • Hygienic and sterilisable products without loss of quality. Still, aerosol cans • Used with eco-friendly air or nitrogen • Effective filling process are currently always made of virgin • Less need for preservatives • Suitable for both liquid and viscous products aluminium even though they could Consumer Benefits • Can be used with standard actuators potentially be manufactured from • Up to 99 per cent product emptying and aerosol cans recycled aluminium instead. • Longer shelf-life with less preservatives What the Future HoldsThe final pressure, when the product before use, since the bag is fully filled and Ongoing developments of BoV includehas been filled through the valve, is does not allow mixing when shaken. valves where two different mediumsnormally between six and nine bars, may be filled, separated from each otherdepending on product configuration. The Low Bioburden into a three-chamber-system. Mixing isproduct in the bag encompasses 60 per The BoV system can provide effected while spraying or by the usercent of the can’s brim capacity, while the microbiological safety to the product after application. Another new featurecompressed gas occupies the remaining as it will only come into contact with under development, which will be40 per cent. the inside barrier film of the bag, and appreciated by the pharma industry, is as a one-way valve system no metering dosage BoV where dosages likeWhen pressure-filling the product contamination will come from outside 100µl or 1ml guarantee a certain numberthrough the valve stem, BoV fillers need the bag. With pre-sterilised bags and of uses for the end consumer, as well asto be aware of the difference in stem cleanroom production, the bioburden the same product quality from the firststroke between the various BoV systems of the product can be minimised. dosage to the last.on the market. For the pharmaceutical market, the cans In the near future, we can expect newWhen choosing a BoV system, the first are most often made of aluminium, even innovative ways to manufacture BoVstep should be to source both the BoV if tinplate BoV systems are also available. with higher speed manufacturing,system and the spray actuator from the Since gamma rays are able to penetrate laminate developments for moresame supplier to guarantee that the aluminium, the most convenient compatibility and decreasing thetotal configuration is compatible. This sterilisation method for BoV products number of laminate layers, as well asis to avoid micro-leakage and secure is gamma irradiation, although aseptic many other steps in developing thethe correct performance of the product. filling is also sometimes used. For gamma next generation of BoV systems.Another important factor when using irradiation of products that cancompressed gases is to select a good be classified as sterile, the most About the authorquality aluminium can. common irradiation dose is a Magnus Hedman is the minimum of 25kGy, even if lower Co-Founder, Partner, MarketingDue to the low permeability rate, BoV is doses are also used. Minimum Director and Businesscompatible with commercially available and maximum irradiation doses Development Manager of Aurenaliquefied propellants. These propellants will need to be validated for Laboratories AB. He is a seasonedmake good choices for products that call each product. The gamma entrepreneur and businessfor a steady dispensing rate over the life irradiation process is carried out development specialist who has been involved inof the can, such as post-foaming gels by sterilisation contractors. Some the medical device and pharma industry for over 20and creams. gamma irradiation providers years. International Sales and Marketing Manager offer full pallet sterilisation, for Swedish respiratory care company AiolosAlmost all fluids and many viscous while sterilisation in ‘tote boxes’ Medical, 1990 to 2000, he co-founded Aurenaproducts can be filled into a BoV system is most common. In the tote Laboratories in 2000 and has developed a range ofas long as the product’s viscosity is low box irradiator, the product is medical devices in BoV packaging for the pharmaenough to get it through the valve stem. loaded into tote boxes, which industry. Email: magnus@aurena.seHowever, the system does not work well are conveyed around thewith products that need to be shaken irradiation source.66