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Best GC Inlet

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You want a flexible and multi-usable GC or GCMS system with increased application range and detection limits? From 1ul injection till automated pyrolysis GCMS.

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Best GC Inlet

  1. 1. You want a flexible and multi-usable GC or GCMS system with increased application range and detection limits!?
  2. 2. Who doesn’t
  3. 3. 4th generation of the world’s most powerful inlet for Gas Chromatography OPTIC Multimode Inlet changes your GC or GCMS into a flexible and multi- usable system with increased application range and detection limits
  4. 4. One Inlet, More Analytical Options OPTIC Inlet is much more than any other Inlet
  5. 5. Compatible with most GC’s
  6. 6. Your GCMS would be able to handle:  Cold and Hot Split/Splitless injections  Pyrolysis (liquid and solid samples)  Large Volume Injections  In-liner derivatisation  LC-GC coupling possibility  Headspace  CryoFocusing on the column  Thermal Desorbtion  On-Column injections  Automatic liner exchange
  7. 7. Direct heating technology Low thermal mass Septum or Merlin Seal Septum purge line Carrier line Split line High power O-ring Liner I.D. = 3.4mm Oven wall Cooling by Air, CO2, LN2 computer modeled temp. profile Max temp.: 600˚C Max ramp : 60˚C/sec Thermocouple Solvent Monitor patented
  8. 8. Benefits of OPTIC Inlet Real Septum Purge flow Different septa ca be used: Plug type Disk type Merlin Microseal ™ Metal column ferrule can be used
  9. 9. Benefits of OPTIC Inlet Low thermal mass >: High temperatures (up to 600°C) Fast ramp rates (up to 60°C/sec) Fast cool down time Relatively large liner diameter (3.4 mm i.d.) >: 150µl At-Once LVI Direct Thermal Desorbtion (DTD) Difficult Matrix Introduction (DMI) In-Liner derivatisation Solid and Liquid sample Pyrolysis Best temperature profile >: good transfer of high molecular components
  10. 10. Temperature profiles No Cold Spot Good for high molecular components
  11. 11.  No discrimination  No evaporate from the syringe needle  More control over the true injected volume  Less thermal degradation (Less problems with thermally labile compounds degrade due to the thermal stress upon injection)  Better reproducibility with SPME  Very good reproducibility, also using CombiPAL Benefits of cold injections
  12. 12. Cold injection versus hot injection Hot injection Cold injection
  13. 13. Performance Hot versus Cold injection Autosampler: AOC 20i, GC-MS: QP 2010, Injector: OPTIC 3, Injection volume: 1 µl, Alkane mix: 0.5 µg/ml Constant 320 Constant 250 Programmed 50 -> 320 Inlet temp.
  14. 14. Benefits of Large Volume Injection Sample vol 1000ml 10ml 10ml Elution vol. 2000µl 2000µl 200µl Mass in 1µl 5pg 0.05pg 0.5pg Injection vol. 1µl 100µl 100µl Mass injected 5pg 5pg 50pg Less sample and solvent is needed and finally more is arrived at the detector. Less sample and solvent is needed and finally more is arrived at the detector.
  15. 15. LVI; Why so good with OPTIC ? (s)10 20 30 40 50 30 o C 15 0 -15 Temp. In the liner C5 C6 EtOAc MeOH Good evaporate cooling effect because inlet body has a very low thermal mass
  16. 16. LVI Solvent Vent Monitor Function in OPTIC Sensor Output Time Inject Vent valve closes Sensor in split lineSensor in split line (standard available)(standard available)
  17. 17. Difficult Matrix Introduction (DMI)  Raw sample or dirty extract is put into micro vial and placed directly into liner In-injector thermal desorption or pyrolysis of liquid or solid samples What is Difficult Matrix Introduction (DMI)?
  18. 18. d) OP TIC Injector e) Ca rrier In Split Flow Column Flow Transport liner with sample into OPTIC inlet Seal and purge the inlet. Apply selective exclusion principle for the analysis: First temperature increased to just below BP of solvent Solvent is vented through split line Temperature and pressure ramped up to achieve selective transfer Dispose microvial after analysis, clean and re-use liner DMI step by step:DMI step by step: What is Difficult Matrix Introduction (DMI)?
  19. 19. Pyrolysis Liquid T (°C) t (min) injection solvent elimination pyrolysis 600 40 0 1 5 Liquid injection: simple to automate pyrolysis Sample inlet Vapour outlet - Temperature program to 600°C - Fast ramp rate (60°C/sec)
  20. 20. Pyrolysis Solid - Sample in micro vial - Fast ramp rate (60°C/sec) - Temperature program to 600°C - Multi-Shot Pyrolysis possible - Evolved Gas Analysis (EGA) possible
  21. 21. On-Column solution  No press fit  No liner  No modification to OPTIC Inlet  Easy installation  Real On-Column  New type Merlin Microseal can be used
  22. 22. CryoTrap Option Different ramp rates for same component. 60°C/sec 30°C/sec 10°C/sec Cryogenic cold trapping is frequently used for narrowing the chromatographic band and improving the detection limit. OPTIC-4 Cryotrap is the fastest heating trap > resulting in sharp peaks
  23. 23. ATAS GL – Thermal Desoption Solution (TDS) Main points:Main points: - Direct heatingDirect heating - Trapping on the column (one desorption from liner to column)Trapping on the column (one desorption from liner to column) - No dead volumeNo dead volume - Real septum purgeReal septum purge - Real Splitless transfer from sample to columnReal Splitless transfer from sample to column
  24. 24. LINERS Fritted liner, frit on 15 mm liner for split injections (single necked) Empty liner for splitless injections Baffled splitless liner Fritted liner on 20 mm with single taper “A” type packed liner for large volume injections “8270” sintered liner for large volume injections Sintered glass liner with taper LINEX DMI Liner DMI Liner Insert (micro vial)
  25. 25. OPTIC Injection Modes  Combined TD / Pyrolysis  Injection port reactor  Micro Headspace / Micro vial  SPME-GC  SPE-GC  TCT-GC  GPC-GC  LC-GC  Comprehensive LC x GC  Automatically changing liners  Hot split injection  Hot splitless injection  Cold split injection  Cold splitless injection  On-column injection  Large Volume Injection  Gas enrichment  Direct thermal desorption  Pyrolysis (in liner)  Headspace
  26. 26. www.glsciences.eu For more information

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