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Endometrial Carcinoma

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Endometrial Carcinoma, Tutor Group, Block 3.1

KFU, Al-Hasa, Saudi Arabia

Published in: Health & Medicine

Endometrial Carcinoma

  1. 1. Endometrial Carcinoma Abdullatiff Sami Al-Rashed Block 3.1 KFU Al-Hassa, Saudi Arabia
  2. 2. Objectives • Anatomy • Definition • Etiology • Pathophysiology & Genetics • Types • Signs & Symptoms • Diagnosis & Staging • Treatment • Prognosis
  3. 3. Anatomy
  4. 4. Definition • Endometrial cancer is a type of cancer that begins in the uterus. • The uterus is the hollow, pear- shaped pelvic organ in women where fetal development occurs. • Endometrial cancer begins in the layer of cells that form the lining (endometrium) of the uterus.
  5. 5. Etiology & Risk Factors • The exact causes of endometrial cancer is unknown. • There are some risk factors increase the chance to have the cancer:
  6. 6. Etiology & Risk Factors
  7. 7. Pathophysiology • Fibroblast growth factor receptor 2 (FGFR2) is a tyrosine kinase receptor involved in many biological processes. • Mutations in FGFR2 have been reported in up to 10- 12% of endometrial carcinomas identical to those found in congenital craniofacial disorders.
  8. 8. Pathophysiology
  9. 9. Genetics • Uterine cancer may run in families where colon cancer is hereditary • Women in families with hereditary non-polyposis colorectal cancer (HNPCC), or Lynch syndrome, have a higher risk for uterine cancer.
  10. 10. Types
  11. 11. Signs & Symptoms
  12. 12. Diagnosis • Transvaginal ultrasound: – To assess endometrial thickness  • Endometrial biopsy: – To confirm the diagnosis • Hysteroscopically directed biopsy • Pelvic MRI
  13. 13. Staging
  14. 14. Treatment • Treatment depends on the stage  and grade of the cancer and the  general health of the woman. 
  15. 15. Treatment • Stage 1a cancers, surgery with total abdominal  hysterectomy and bilateral salpingo-oopherectomy  is usually sufficient treatment. 
  16. 16. Treatment • Women with stage 1b or 2  disease adjuvant pelvic  radiotherapy is given, which  reduces the rate of local  recurrence. • Radiotherapy may be used as  the primary treatment in women  unfit to undergo surgery or in  women with locally advanced  disease (stage 3 and 4a).   
  17. 17. Treatment • Chemotherapy using carboplatin and paclitaxel, or  cisplatin and doxorubicin can improve disease  control and symptoms in patients with recurrent  disease but the impact on survival is limited. 
  18. 18. Prognosis • Endometrial cancer has the best prognosis of all the gynecological cancers. • Poor prognostic indicators include older age, advanced stage, high-grade tumors and adenosquamous histology.
  19. 19. Prognosis 5-year survival:
  20. 20. Conclusion • Endometrial cancer begins in the layer of cells that form the lining (endometrium) of the uterus. • The exact causes of endometrial cancer is unknown. • Obesity, hormonal imbalance and nulliparity are risk factors of endometrial cancer • Vaginal bleeding, Pelvic pain, Dyspareunia, dysuria are the symptoms of Endometrial cancer • Treatment depends on the stage and grade of the cancer and the general health of the woman.
  21. 21. References • Oncology at a Glance Graham G. Dark 1st edition. • http://www.cancer.org • http://emedicine.medscape.com

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