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Omeneu instant (Asma Saleem Product Manager Neutro Pharma)

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Omeneu instant (Asma Saleem Product Manager Neutro Pharma)

  1. 1. Omeneu Instant (Omeprazole +Sodiumbicarbonate)
  2. 2. Digestive System • Esophagus( tube that connects your mouth and your stomach) • Stomach • Small Intestine • Large Intestine • Gall bladder • Liver • Pancreas
  3. 3. Stomach • A stretchy bag that holds your food after you eat. Stomach has 4 major roles in human body. • • • • Esophagus To store food To mix the food with HCl and pepsin To reduce the size of food particles To empty the partially digested food into the small intestine Stomach
  4. 4. Stomach Cells • Parietal cells (oxyntic cells) are the stomach epithelium cells which secrete gastric acid. • Parietal cells produce gastric acid (hydrochloric acid) in response to histamine (via H2 receptors), acetylcholine (M3 receptors) and gastrin (gastrin receptors). • Parietal cells contain an extensive secretary network (canaliculi) from which the HCl is secreted by active transport into the stomach.
  5. 5. Acid-Related Pathophysiology The stomach secretes: • Hydrochloric acid (HCl) • Bicarbonates • Pepsinogen • Mucus • Prostaglandins
  6. 6. Gastroesophageal Reflux Disease (GERD • Most common disorder of esophagus • Characterized by regurgitation of gastric contents into esophagus and exposure of esophageal mucous to gastric acid and pepsin. • Main symptom is heart burn – occurs after eating.
  7. 7. Complications of GERD • Esophagitis, stricture or ulcer • Barrett’s Esophagus
  8. 8. Peptic Ulcer • Condition characterized by Erosion of GI mucosa resulting from digestiveaction of HCl and pepsin • Ulcer development – Lower esophagus – Stomach – Duodenum
  9. 9. Gastric Ulcer • common in late middle age – incidence increases with age • Use of NSAIDs - associated with a three- to four-fold increase in risk of gastric ulcer • Less related to H. pylori than duodenal ulcers – about 80% • 10 - 20% of patients with a gastric ulcer have a concomitant duodenal ulcer.
  10. 10. Duodenal Ulcer • Duodenal sites are common as gastric sites • Most common in middle age • Male to female ratio—4:1 • Associated with increased serum pepsinogen • H. pylori infection common up to 95% • Smoking is twice as common
  11. 11. Helicobacter Pylori (H. pylori) • Helicobacter Pylori (H. pylori) is a spiral shaped bacterium found in the stomach. • H. pylori damages stomach and duodenal tissue • Causes 80% of peptic ulcers • Survives the acid environment by attaching to the sugar molecules that line the stomach wall • Uses the mucus layer as protection
  12. 12. Zollinger-Ellison Syndrome • Zollinger-Ellison Syndrome is a rare disorder that causes one or more tumors to form in the pancreas or • upper part of the small intestine called the duodenum. • The tumorsare called gastrinomas, and they secrete a large amountof the hormone gastrin. • In this syndrome increased levels of the hormone gastrin are produced, causing the stomach to produce excess
  13. 13. Release of Gastric Acid • Histamine stimulates acid release by interacting with the histamine receptor • Acetylcholine activates the cholinergic receptors • Gastrin is released when food is present in the stomach
  14. 14. Proton Pump Inhibitor Mode of Action Proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. Blocks the enzyme in the wall of the stomach that produces acid.
  15. 15. Antacids • Quick but short term • Buffer gastric acid, increasing the pH • Neutralize acid by the following reaction NaHCO3 + HCl NaCl + H2O + CO2
  16. 16. Dosage Schedule Indication Dose Frequency Short-Term Treatment of Active Duodenal Ulcer 20mg Once daily for 4 weeks Benign Gastric Ulcer 40mg Once daily for 4-8 weeks Gastroesophageal Reflux Disease (GERD) Symptomatic GERD (with no esophageal erosions) 20mg Once daily for up to 4 weeks Erosive Esophagitis 20mg Once daily for 4-8 weeks Maintenance of Healing of Erosive Esophagitis 20mg Once daily

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