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Tavanic is an antibiotic for pneumonia and urinary tract infections.The presentation made by a medical representative from Sanofi during the 3rd Ask A Doc Dinner

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  1. 1. TAVANIClevofloxacin 1
  2. 2. Mode Of ActionRapid bactericidal action: inhibits DNA gyrase (resealing) inhibits topoisomerase IV (no separation of interlinked daughter DNA molecules) 2
  3. 3. Pharmacokinetics Rapid, complete absorption after oral administration 100% bioavailable T-max : 1 hour IV and oral formulations are bioequivalent  switch / sequential therapy Minimal hepatic metabolism; 2 metabolites identified in urine (<5% of total Levofloxacin) Half life is 6 – 8 hours once daily dosage 3
  4. 4. Indicationsa) Upper respiratory tract infections – sinusitis due to: GRAM-POSITIVE GRAM-NEGATIVE * M. catarrhalis ** S. pneumoniae H. influenzae *** S. aureus *** H. parainfluenzae * -lactamase producers ** intraphagocytic 6
  5. 5. Indications (Cont…)b) Lower respiratory tract infections: acute exacerbation of chronic bronchitis (AECB) due to: GRAM-POSITIVE GRAM-NEGATIVE * M. catarrhalis ** H. influenzae *** S. pneumoniae H. parainfluenzae S. aureus *** K. pneumoniae* E. coli* * -lactamase producers ** intraphagocytic 7
  6. 6. Indications (Cont…)c) Lower respiratory tract infections (cont): Community acquired pneumonia (CAP) due to: GRAM- GRAM- ATYPICAL POSITIVE NEGATIVE BACTERIA S. pneumoniae M. catarrhalis*** M. pneumoniae *** * * S. aureus ** H. influenzae ** C. pneumoniae *** H. parainfluenzae L. pneumophila *** K. pneumoniae* E. coli* * -lactamase producers ** intraphagocytic *** intracellular 8
  7. 7. Indications (Cont…)e) Skin and soft tissue infections: uncomplicated infections such as abscess, cellulitis, carbuncles,impetigo due to: GRAM-POSITIVE GRAM-NEGATIVE Acinitobacter Enterobacter S. aureus ** P. mirabilis S. pyogenes P. aeruginosa S. faecalis E. coli* K. pneumoniae* * -lactamase producers ** intra-phagocytic 10
  8. 8. Indications (Cont…)f) Complicated skin and soft tissue infections such as diabetic foot ulcers, pressure sores, traumatic and post- surgical wound infections due to: GRAM-POSITIVE GRAM-NEGATIVE P. mirabilis S. aureus* E. coli* S. pyogenes K. pneumoniae* S. faecalis Enterobacter K. oxytoca * -lactamase producers ** intra-phagocytic 11
  9. 9. Dosage500mg once daily, which enhances patientcompliance.Bioequivalent Oral or IV , allows for switchtherapy.Dosage and duration depends on the type andseverity of infection.Continue for a further 48 - 72 hours after patientis afebrile or evidence of bacteriologicaleradication. 13
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