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Leprosy

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Leprosy

  1. 1. By:Armin Eisazaei, II Pharm.DAl Ameen College of Pharmacy,Bangalore_560027
  2. 2. INTRODUCTION
  3. 3. Epidemiology
  4. 4. 
  5. 5. Signs of leprosy
  6. 6. Symptoms
  7. 7.  Indeterminate leprosy:Types of leprosy
  8. 8. Indeterminate leprosy:
  9. 9.  A few hypopigmented macules, some are large andsome become anesthetic (lose pain sensation) someneural involvement in which nerves becomeenlarged;spontaneous resolution in a few years, persists oradvances to other forms.Tuberculoid leprosy
  10. 10. Tuberculoid leprosy
  11. 11. Borderline tuberculoid leprosy
  12. 12. Borderline tuberculoid leprosy
  13. 13. .Borderline lepromatous leprosy
  14. 14. Borderline lepromatous leprosy
  15. 15. .Mid-borderline leprosy
  16. 16. Mid-borderline leprosy
  17. 17. Lepromatous leprosy
  18. 18. Lepromatous leprosy
  19. 19. Pathology
  20. 20. 
  21. 21. •Transmission
  22. 22. Who is at risk?
  23. 23. 
  24. 24. .
  25. 25. 
  26. 26.  :1) Early detection of patients2) Appropriate treatment3) Adequate care for the prevention of disabilities andrehabilitation
  27. 27. .
  28. 28. 
  29. 29. M.O.A:PK:ADRs:Dapsone
  30. 30.  M.O.A: • Specific inhibitors of bacterial RNA polymerase • Acts by binding to and inhibiting DNA dependentRNA polymerase • Active against gram + ve and may be gram – vespecies.
  31. 31. 
  32. 32. 
  33. 33. •M.O.A:PKADRs:
  34. 34. RFP DapsoneAdult 50-70kg 600mg/m 100mg/dChild 10-14 years 450mg/m 50mg/d‘’Less than 10 years’’ 300mg/m 25mg/dMultidrug Therapy for Paucibacillary (PB) Leprosy
  35. 35. RFP Dapsone CLFAdult 50-70kg 600mg/m 100mg/d 50mg/d&300mg/mChild 10-14 years 450mg/m 50mg/d 50mg/d &150mg/mLess than 10 years 300mg/m 25mg/d 50mg twice/d&100mg/mMultidrug Therapy for Multibacillary (MB)Leprosy
  36. 36.  • Harissons • Rang and Dale • CIMSReferences:
  37. 37. Good Luck…

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