Keynote: SECOND INTERNATIONAL WORKSHOP IN MULTIMEDIA PRAGMATICSMMPrag 2019, San Jose, California, 28-30 March 2019 http://mipr.sigappfr.org/19/keynote-speakers/ The Holy Grail of machine intelligence is the ability to mimic the human brain. In computing, we have created silos in dealing with each modality (text/language processing, speech processing,image processing, video processing, etc.). However, the human brain’s cognitive and perceptual capability to seamlessly consume (listen and see) and communicate (writing/typing, voice, gesture) multimodal (text, image, video, etc.) information challenges the machine intelligence research. Emerging chatbots for demanding health applications present the requirements for these capabilities. To support the corresponding data analysis and reasoning needs, we have to explore a pedagogical framework consisting of semantic computing, cognitive computing, and perceptual computing (http://bit.ly/w-SCP). In particular, we have been motivated by the brain’s amazing perceptive power that abstracts massive amounts of multimodal data by filtering and processing them into a few concepts (representable by a few bits) to act upon. From the information processing perspective, this requires moving from syntactic and semantic big data processing to actionable information that can be weaved naturally into human activities and experience (http://bit.ly/w-CHE). Exploration of the above research agenda, including powerful use cases, is afforded in a growing number of emerging technologies and their applications - such as chatbots and robotics. In this talk, I will provide these examples and share the early progress we have made towards building health chatbots (http://bit.ly/H-Chatbot) that consume contextually relevant multimodal data and support different forms/modalities of interactions to achieve various alternatives for digital health (http://bit.ly/k-APH). I will also discuss the indispensable role of domain knowledge and personalization using domain and personalized knowledge graphs as part of various reasoning and learning techniques.