Cell & MolecularBiology
Enzymeand GenerallyProteinRegulation
Chapters 3 & 4
EnzymeKinetics
Turnover Number
“...how rapidlythe substratecan be processed.”
Figure 3-26a Essential Cell Biology (© Garland Science 2010)
Figure 3-26b Essential Cell Biology (© Garland Science 2010)
Figure 3-24 Essential Cell Biology (© Garland Science 2010)
Enzymes and substratesencounter each otherthrough diffusion.
Figure 3-22 Essential Cell Biology (© Garland Science 2010)
Inhibitors
Estrogen receptorwith DNA andestradiol bound         http://www.pdb.org/pdb/static.do?         p=education_discussion/    ...
Tamoxifen      blocks      the action      of estrogenhttp://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_...
CompetitiveInhibition
Figure 3-28a Essential Cell Biology (© Garland Science 2010)
Figure 3-28b Essential Cell Biology (© Garland Science 2010)
Trypsin           h"p://cnx.org/content/m11456/latest/          Benzamidine
NoncompetitiveInhibition
FeedbackInhibition
Figure 4-34 Essential Cell Biology (© Garland Science 2010)
NegativeRegulation
Figure 4-35 Essential Cell Biology (© Garland Science 2010)
Figure 4-36 Essential Cell Biology (© Garland Science 2010)
AllostericRegulation
ProteinPhosphorylation
The reversible additionof a phosphate groupto a protein.
Figure 4-38a Essential Cell Biology (© Garland Science 2010)
Figure 4-38b Essential Cell Biology (© Garland Science 2010)
GTP Binding
Figure 4-39 Essential Cell Biology (© Garland Science 2010)
Elongation FactorEF-TutRNA           http://www.rcsb.org/pdb/           101/motm.do?momID=81
MCB: Enzymatic Pathways and Regulation
MCB: Enzymatic Pathways and Regulation
MCB: Enzymatic Pathways and Regulation
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MCB: Enzymatic Pathways and Regulation

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MCB: Enzymatic Pathways and Regulation

  1. 1. Cell & MolecularBiology
  2. 2. Enzymeand GenerallyProteinRegulation
  3. 3. Chapters 3 & 4
  4. 4. EnzymeKinetics
  5. 5. Turnover Number
  6. 6. “...how rapidlythe substratecan be processed.”
  7. 7. Figure 3-26a Essential Cell Biology (© Garland Science 2010)
  8. 8. Figure 3-26b Essential Cell Biology (© Garland Science 2010)
  9. 9. Figure 3-24 Essential Cell Biology (© Garland Science 2010)
  10. 10. Enzymes and substratesencounter each otherthrough diffusion.
  11. 11. Figure 3-22 Essential Cell Biology (© Garland Science 2010)
  12. 12. Inhibitors
  13. 13. Estrogen receptorwith DNA andestradiol bound http://www.pdb.org/pdb/static.do? p=education_discussion/ molecule_of_the_month/pdb45_1.html
  14. 14. Tamoxifen blocks the action of estrogenhttp://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb45_1.html
  15. 15. CompetitiveInhibition
  16. 16. Figure 3-28a Essential Cell Biology (© Garland Science 2010)
  17. 17. Figure 3-28b Essential Cell Biology (© Garland Science 2010)
  18. 18. Trypsin h"p://cnx.org/content/m11456/latest/ Benzamidine
  19. 19. NoncompetitiveInhibition
  20. 20. FeedbackInhibition
  21. 21. Figure 4-34 Essential Cell Biology (© Garland Science 2010)
  22. 22. NegativeRegulation
  23. 23. Figure 4-35 Essential Cell Biology (© Garland Science 2010)
  24. 24. Figure 4-36 Essential Cell Biology (© Garland Science 2010)
  25. 25. AllostericRegulation
  26. 26. ProteinPhosphorylation
  27. 27. The reversible additionof a phosphate groupto a protein.
  28. 28. Figure 4-38a Essential Cell Biology (© Garland Science 2010)
  29. 29. Figure 4-38b Essential Cell Biology (© Garland Science 2010)
  30. 30. GTP Binding
  31. 31. Figure 4-39 Essential Cell Biology (© Garland Science 2010)
  32. 32. Elongation FactorEF-TutRNA http://www.rcsb.org/pdb/ 101/motm.do?momID=81

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