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Fertilization(mosly mice and mammals)
Chapter 10
Cumulus Cells                  Follicle cells             shed with the egg            when it is released
Hyaluronic Acid            major component of         the extracellular matrix
Hyaluronidase                       enzyme            in the sperm head
Zona Pellucida     Extracellular glycoproteins        surrounding the oocyte,        secreted by follicle cells
ZP1, ZP2, ZP3            Three glycoproteins         that comprise the zona
Glycoprotein                   Protein with               sugars attached
GalT       The sperm-surface protein                that binds to ZP3,                       resulting in           the ar...
Arcosome Reaction           Rapid exocytosis of         the arcosomal vesicle            containing arcosin
Arcosin           A serine protease          that digests a path            through the zona
ADAM Proteins        Sperm proteins that bind    integrins on the egg surface
Integrins                 “...receptors that            mediate attachment...”
Cell fusion       The joining of membranes           and ultimately of cellsleads to the rise ofintracellular [Ca2+] and
Release ofcortical granules    Secretory vesicles containing     glycosidases and proteasesmodifies the zonaso sperm canno...
Glycosidase        Enzyme that hydrolyzes            glycosidic linkages
Preventspolyspermy         Fertilization of an egg       by more than one sperm
Completion ofsecond meiotic division(expulsion of second polar body)
Pronuclei breakdown.Chromosomes alignfor first cleavage.Centriole forms the firstmitotic spindle
Fertilization
Fertilization
Fertilization
Fertilization
Fertilization
Fertilization
Fertilization
Fertilization
Fertilization
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Fertilization

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Fertilization

  1. 1. Fertilization(mosly mice and mammals)
  2. 2. Chapter 10
  3. 3. Cumulus Cells Follicle cells shed with the egg when it is released
  4. 4. Hyaluronic Acid major component of the extracellular matrix
  5. 5. Hyaluronidase enzyme in the sperm head
  6. 6. Zona Pellucida Extracellular glycoproteins surrounding the oocyte, secreted by follicle cells
  7. 7. ZP1, ZP2, ZP3 Three glycoproteins that comprise the zona
  8. 8. Glycoprotein Protein with sugars attached
  9. 9. GalT The sperm-surface protein that binds to ZP3, resulting in the arcosome reaction
  10. 10. Arcosome Reaction Rapid exocytosis of the arcosomal vesicle containing arcosin
  11. 11. Arcosin A serine protease that digests a path through the zona
  12. 12. ADAM Proteins Sperm proteins that bind integrins on the egg surface
  13. 13. Integrins “...receptors that mediate attachment...”
  14. 14. Cell fusion The joining of membranes and ultimately of cellsleads to the rise ofintracellular [Ca2+] and
  15. 15. Release ofcortical granules Secretory vesicles containing glycosidases and proteasesmodifies the zonaso sperm canno longer bind
  16. 16. Glycosidase Enzyme that hydrolyzes glycosidic linkages
  17. 17. Preventspolyspermy Fertilization of an egg by more than one sperm
  18. 18. Completion ofsecond meiotic division(expulsion of second polar body)
  19. 19. Pronuclei breakdown.Chromosomes alignfor first cleavage.Centriole forms the firstmitotic spindle

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