Embryonic development

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Embryonic development

  1. 1. EmbryonicDevelopment(mosly mice and mammals)
  2. 2. Chapter 10
  3. 3. Cleavage Cell division without growth First few divisions are slow (24 hrs, then12 hrs)
  4. 4. Blastomeres Products of cleavage
  5. 5. Compaction Developing embryo becomes more spherical. Flattening of blastomeres to form to maximize intracellular contacts.
  6. 6. Microvilli Cell membrane protrusionsand Gap Junctions Cellular connections joining cell cytoplasmsform
  7. 7. MicrovilliPorter, Fonte and Weiss, Cancer Research, 1974
  8. 8. Figure 20-22 Essential Cell Biology (© Garland Science 2010)
  9. 9. Gap Junctions connexon proteins
  10. 10. Morula Embryo from compaction to about the 32-cell stage
  11. 11. Desmosomesand tight junctionsform
  12. 12. Desmosomes Localized, spot-like, cell-to-cell adhesions
  13. 13. Figure 20-22 Essential Cell Biology (© Garland Science 2010)
  14. 14. Figure 17-2a Essential Cell Biology (© Garland Science 2010)
  15. 15. Figure 17-2b Essential Cell Biology (© Garland Science 2010)
  16. 16. Tight Junctions Junctions sealing neighboring cells together so that water-soluble molecules cannot easily leak between them
  17. 17. Figure 20-22 Essential Cell Biology (© Garland Science 2010)
  18. 18. Figure 20-23a, b Essential Cell Biology (© Garland Science 2010)
  19. 19. Figure 20-23c Essential Cell Biology (© Garland Science 2010)
  20. 20. Blastocoel Fluid-filled cavitybegins to form, forming...
  21. 21. the Blastocyst Mammalian embryo after cavitation
  22. 22. the Blastocyst, Mammalian embryo after cavitationconsisting of theTrophoectoderm, Blastocoeland Inner Cell Mass
  23. 23. Trophoectoderm The outer layer of the blastocyst, which will form part of the placenta
  24. 24. Inner Cell Mass Will form the “embryo proper” and the amnion
  25. 25. Amnion Extraembryonic membrane enclosing the embryo
  26. 26. Fig. 3.20Principles of Development 4e Wolpert/Tickle Copyright © 2011 by Oxford University Press
  27. 27. ICM and trophoectoblastcells become determined
  28. 28. Late Blastocyst Formation of distinct regions
  29. 29. Implantation Emergence from the zona Attachment to the uterine wall Initial formation of the placenta
  30. 30. “Hatching” Emergence from the zona; trophoectoderm cells opposite the ICM secrete a protease that digest the zona
  31. 31. Fig. 3.23Principles of Development 4e Wolpert/Tickle Copyright © 2011 by Oxford University Press

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