Snake Bites- Dr Sabah

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Snake Bites- Dr Sabah

  1. 1. SNAKE BITE Presentation by – Dr Sabah
  2. 2. INTRODUCTION  Ophitoxaemia is the term that characterizes the clinical spectrum of snake bite envenomation.  Of the 2500-3000 species of snakes distributed world-wide, about 500 are venomous  Snake bite is an occupational hazard of rice farmers; rubber, coffee and other plantation workers; fishermen and those who handle snakes.
  3. 3. EPIDEMIOLOGY  The true scale of mortality and acute and chronic morbidity from snake bite remains uncertain because of inadequate reporting in almost every part of the region.  35,000 – 40,000 deaths/year in India  The large majority (90%) are in males aged 11-50 years  In the Indian setting, almost two-thirds of bites are attributed to saw-scaled viper , about one fourth to Russell's viper and smaller proportions to cobra and kraits
  4. 4. Medically important snakes Important groups of venomous snakes in South-East Asia –  Elapidae  Viperidae  Colubridae  Hydrophidae
  5. 5. Short, permanently erect, fangs of a typical elapid Family Elapidae Highly venomous snakes -This family includes the cobras, king cobra, spitting cobra kraits, coral snakes and the sea snakes
  6. 6. The Cobra
  7. 7. Krait Banded krait (Bungarus fasciatus)
  8. 8. Viperidae have long fangs which are normally folded up against the upperjaw when the snake strikes, are erected. There are two subgroups,  the typical vipers (Viperinae) and  the pit vipers (Crotalinae).
  9. 9. Russell’s vipers Saw-scaled viper
  10. 10. The Crotalinae have a special sense organ, the pit organ. Heat-sensitive This is situated between the nostril and the eye
  11. 11. Quantity of venom injected at a bite  depending on the species  the mechanical efficiency of the bite,  venom is usually injected subcutaneously or intramuscularly.  50% snake bites are dry bites  Bites by small snakes should not be ignored
  12. 12. Snake venom  Venom is a substance which is capable of producing toxic reactions when introduced into another animal  Snake venoms contain more than 20 different constituents, mainly proteins, including enzymes and polypeptide toxins
  13. 13. Procoagulant enzymes (Viperidae)  Stimulatebloodclottingbut result in incoagulable blood.  activate different steps of the clotting cascade.  formation of fibrin in the blood stream.  immediately broken down by the body’s own fibrinolytic system. “consumption coagulopathy”
  14. 14. Enzymes - contd  Haemorrhagins (zinc metalloproteinases)- damage the endothelial lining of blood vessel walls causing spontaneous systemic haemorrhage.  Cytolytic ornecrotic toxins - these digestive hydrolases (proteolytic enzymes and phospholipases A) - increase permeability resulting in local swelling. They may also destroy cell membranes and tissues.  Haemolytic and myolytic phospholipases A2 - these enzymes damage cell membranes, endothelium, skeletal muscle, nerve and red blood cells.
  15. 15. Neuro-toxins  Pre-synaptic neurotoxins (Elapidae and some Viperidae) –  Highly specific pre-synaptic calcium channel blockers- Inhibit vesicle availability irreversibly  -these are phospholipases A2  Post-synaptic neurotoxins (Elapidae) –  Non-lethal post-synaptic acetylcholine receptor antagonists  compete with acetylcholine for receptors in the neuromuscular junction and lead to curare-like paralysis.
  16. 16. Symptoms and Signs of Snake Bite When venomhas not been injected  Anxious people may overbreathe  stiffness or tetany of their hands and feet and dizziness.  Vasovagal shock after the bite or suspected bite – faintness and collapse with bradycardia  Agitated and irrational  Due to first aid and traditional treatments.
  17. 17. When venomhas been injected Local symptoms and signs in the bitten part  fang marks  local pain  local bleeding  bruising  lymphangitis  lymph node enlargement  inflammation (swelling, redness, heat)  blistering  local infection, abscess formation  necrosis
  18. 18. systemic symptoms and signs General –  Nausea, vomiting, malaise, abdominal pain,  weakness,  drowsiness, prostration
  19. 19. Cardiovascular(Viperidae)  Visual disturbances,  dizziness, faintness, collapse,  shock, hypotension,  cardiac arrhythmias,  pulmonary oedema,  conjunctival oedema
  20. 20. Bleedingandclotting disorders (Viperidae)  bleeding from recent wounds  spontaneous systemic bleeding – - from gums , epistaxis, haemoptysis haematemesis, melaena, haematuria, vaginal bleeding, - bleeding into the skin (petechiae, purpura, ecchymoses) and mucosae (eg conjunctivae ) - intracranial haemorrhage
  21. 21. Neurological(Elapidae, Russell’s viper)  Drowsiness, paraesthesiae, abnormalities of taste and smell,  ptosis, external ophthalmoplegia  paralysis of facial muscles  aphonia, difficulty in swallowing secretions,  respiratory and generalised flaccid paralysis
  22. 22. Renal(Viperidae, sea snakes)  Loin pain, haematuria, haemoglobinuria, myoglobinuria, oliguria/anuria  symptoms and signs of uraemia -acidotic breathing, hiccups, nausea, pleuritic chest pain
  23. 23. Skeletal musclebreakdown(seasnakes, Russell’s viper) Generalised pain, stiffness and tenderness of muscles, trismus, myoglobinuria ,hyperkalaemia, cardiac arrest, acute renal failure Endocrine(acutepituitary/adrenal insufficiency) (Russell’s viper)  Acute phase: shock, hypoglycaemia  Chronic phase (months to years after the bite): weakness, loss of secondary sexual hair, amenorrhoea, testicular atrophy, hypothyroidism etc
  24. 24. Clinical syndromes of snake bite in South-East Asia Syndrome 1  Local envenoming (swelling etc) with bleeding/clotting disturbances = Viperidae
  25. 25. Syndrome 2  Local envenoming with bleeding/clotting disturbances, shock or renal failure = Russell’s viper and possibly saw-scaled viper  with conjunctival oedema (chemosis) and acute pituitary insufficiency = Russell’s viper,  with ptosis, external ophthalmoplegia, facial paralysis and dark brown urine =Russell’s viper
  26. 26. Syndrome 3  Local envenoming with paralysis = cobra or king cobra Syndrome 4  Paralysis with minimal or no local envenoming Bite on land while sleeping = krait , cobra Bite in the sea = sea snake
  27. 27. Syndrome 5  Paralysis with dark brown urine and renal failure: Bite on land (with bleeding/clotting disturbance) = Russell’s viper Bite in the sea (no bleeding/clotting disturbances) = sea snake
  28. 28. Sequelae of snake bite  chronic ulceration, infection, osteomyelitis or arthritis  Malignant transformation may occur in skin ulcers  Chronic renal failure occurs after bilateral cortical necrosis (Russell’s viper bites)  chronic panhypopituitarism or diabetes insipidus (Russell’s viper bite)  Chronic neurological deficit is seen in the few patients who survive intracranial haemorrhages (Viperidae)
  29. 29. Symptoms and Signs of Cobra-spit Ophthalmia  Intense burning, stinging pain, profuse watering of the eyes  Production of whitish discharge, congested conjunctivae,  Spasm and swelling of the eyelids, clouding of vision.  Corneal ulceration, permanent corneal scarring and secondary endophthalmitis
  30. 30. Management  First aid treatment  Transport to hospital  Rapid clinical assessment and resuscitation  Detailed clinical assessment and species diagnosis  Investigations/laboratory tests  Antivenom treatment  Observation of the response to antivenom: decision about the need for further dose(s) of antivenom  Supportive/ancillary treatment  Treatment of the bitten part  Rehabilitation  Treatment of chronic complications
  31. 31. First aid treatment Aims of first aid  attempt to retard systemic absorption of venom  preserve life and prevent complications before the patient can receive medical care  control distressing or dangerous early symptoms of envenoming  arrange the transport of the patient to a place where they can receive medical care
  32. 32. Recommended first aid methods  Reassure the victim who may be very anxious  Immobilise the bitten limb with a splint or sling  Consider pressure-immobilisation for some elapid bites  Avoid any interference with the bite wound as this may introduce infection, increase absorption of the venom and increase local bleeding
  33. 33. Pressure immobilisation method  Pressure immobilisation is recommended for bites by neurotoxic elapid snakes, including sea snakes  should not be used for viper bites because of the danger of increasing the local effects of the necrotic venom.  Tight (arterial) tourniquets are not recommended!
  34. 34. Pressure immobilisation method. Recommended first-aid for bites by neurotoxic elapid snakes (by courtesy of the Australian Venom Research Unit, University of Melbourne)
  35. 35. Treatment in the hospital  Rapid clinical assessment and resuscitation  Airway, Breadthing ,Circulation must be checked  consciousness must be assessed.
  36. 36. Detailed clinical assessment  History  Physical examination Examinationof thebittenpart The extent of swelling, extent of tenderness Lymph nodes  A bitten limb may be tensely oedematous, cold, and with impalpable arterial pulses.  Early signs of necrosis may include blistering, demarcated darkening or paleness of the skin, loss of sensation and a smell of putrefaction
  37. 37. General examination  blood pressure , heart rate.  skin and mucous membrane - evidence of petechiae, purpura, ecchymoses  conjunctivae - chemosis.  nose for epistaxis.  Abdominal tenderness may suggest gastrointestinal or retroperitoneal bleeding.  Loin pain and tenderness suggests acute renal ischaemia  Intracranial haemorrhage is suggested by lateralising neurological signs, asymmetrical pupils, convulsions or impaired consciousness
  38. 38. Neurotoxic envenoming  Examination forptosis, usually the earliest sign of neurotoxic envenoming  Test eye movements for evidence of early external ophthalmoplegia  Check the size and reaction of the pupils.  early restriction in mouth opening may indicate trismus (sea snake envenoming)  Paralysis of pterygoid muscles  facial muscles, tongue, gag reflex .  The muscles flexing the neck may be paralysed giving the “broken neck sign”
  39. 39. Bulbarandrespiratoryparalysis  Dysphagia , pooling of secretions in pharynx  “Paradoxical respiration”  Do not assume that patients have irreversible brain damage because they are areflexic, unresponsive to painful stimuli, or have fixed dilated pupils.
  40. 40. Investigations  20 minute whole blood clotting test (20WBCT)  Haemoglobinconcentration/haematocrit  Platelet count - may be decreased in victims of viper bites.  Whitebloodcellcount- early neutrophil leucocytosis  coagulation profile  Bloodfilm: fragmentedredcells (“helmet cell”, schistocytes)  Arterialbloodgases andpH.
  41. 41. Biochemical abnormalities  aminotransferases andmuscleenzymes (creatine kinase, aldolase etc) will be elevated  Mild hepatic dysfunction is reflected in slight increases in other serum enzymes.  Bilirubin is elevated following massive extravasation of blood.  Creatinine, urea or blood urea nitrogen levels elevated  Early hyperkalaemia may be seen following extensive rhabdomyolysis  Bicarbonate will be low in metabolic acidosis
  42. 42. Grading Scale forSeverity of Snake Bites Degreeof envenomation Presentation 0. None Punctures or abrasions; some pain or tenderness at the bite I. Mild Pain, tenderness, edema at the bite; perioral paresthesias may be present. II. Moderate Pain, tenderness, erythema, edema beyond the area adjacent to the bite; often, systemic manifestations and mild coagulopathy III. Severe Intense pain and swelling of entire extremity, often with severe systemic signs and symptoms;coagulopathy IV. Life- threatening Marked abnormal signs and symptoms; severe coagulopathy
  43. 43. Antivenomtreatment Antivenom is immunoglobulin (usually the enzyme refined F(ab)2 fragment of IgG)  purified from the serum or plasma of a horse or sheep that has been immunised with the venoms of one or more species of snake.  Monovalent or monospecific antivenom neutralises the venom of only one species of snake  Polyvalent or polyspecific antivenom neutralises the venoms of several different species of snakes,
  44. 44. Haffkine, Kasauli, Serum Institute of India and Bengal “polyvalent anti-snake venom serum” is raised in horses using the venoms of t he four most important venomous snakes in India (Indian cobra, Indian krait, Russe ll’s vipe r, saw-scale d vipe r. )
  45. 45. Indications forantivenom Hae m o static abno rm alitie s: spo ntane o us syste m ic ble e ding , coagulopathy (20WBCT orotherlaboratory) or thrombocytopenia Neurotoxic signs: ptosis, external ophthalmoplegia, paralysis Cardio vascular abno rm alitie s: hypo te nsio n, sho ck, cardiac arrhythm ia abnormal ECG Acute re nalfailure : o lig uria/anuria , rising blo o d cre atinine / ure a Hae m o g lo bin-/m yo g lo bin-uria: dark bro wn urine , evidence of intravascular haemolysis or generalised rhabdomyolysis (muscle aches and pains, hyperkalaemia)
  46. 46. Local envenoming  Local swelling involving more than half of the bitten limb  Swelling after bites on the digits (toes and especially fingers)  Rapid extension of swelling (for example beyond the wrist or ankle within a few hours of bites on the hands or feet)  Development of an enlarged tender lymph node draining the bitten limb
  47. 47.  Antivenom treatment should be given as soon as it is indicated.  It may reverse systemic envenoming even when this has persisted for several days or, in the case of haemostatic abnormalities, for two or more weeks.  However, when there are signs of local envenoming, without systemic envenoming, antivenom will be effective only if it can be given within the first few hours after the bite.
  48. 48. Contraindications to antivenom  no absolute contraindication to antivenom treatment,  reacted to horse (equine) or sheep (ovine) serum in the past (for example after treatment with equine anti-tetanus serum, equine anti- rabies serum )  strong history of atopic diseases (especially severe asthma) should be given antivenom only if they have signs of systemic envenoming.
  49. 49. Selection of antivenom  Polyspecific/polyvalent antivenoms are preferred in many countries because of the difficulty in identifying species responsible for bites - a larger dose  If the biting species is known, - monospecific/ monovalent antivenom - a lower dose  Liquid antivenoms that have become opaque should not be used  Skin testing not recommended
  50. 50. Administration of antivenom  Epinephrine (adrenaline) should always be drawn up in readiness before antivenom is administered.  Antivenom should be given by the intravenous route whenever possible.  Freeze-dried (lyophilised) antivenoms are reconstituted, usually with 10 ml of sterile water for injection per ampoule.  Intravenous “push” injection: slow intravenous injection (not more than 2 ml/minute).  Intravenous infusion: 250-500 ml of isotonic saline or 5% dextrose and is infused at a constant rate over a period of about one hour.
  51. 51.  Local administration of antivenom at the site of the bite is not recommended!  Intramuscular injection of antivenom - large molecules (F(ab )2 are absorbed slowly via lymphatics.  Bioavailability is poor  pain of injection of large volumes of antivenom  never be injected into the gluteal region (upper outer quadrant of the buttock) as absorption is exceptionally slow and unreliable and there is always the danger of sciatic nerve damage
  52. 52. Dose of antivenom  Snakes inject the same dose of venom into children and adults. Children must therefore be given exactly the same dose of antivenom as adults.  Initial dose of 5-6 vials of polyvalent antisnake venom  In practice, the choice of an initial dose of antivenom is usually empirical.
  53. 53. Antivenom reactions  Early anaphylactic reactions: - urticaria, dry cough fever, nausea, vomiting, abdominal colic, diarrhoea and tachycardia.  Complement activation by IgG aggregates or residual Fc fragments or direct stimulation of mast cells or basophils by antivenom protein are more likely mechanisms for these reactions.
  54. 54. Treatment  Epinephrine (adrenaline) is given intramuscularly (into the deltoid muscle or the upper lateral thigh) in an initial dose of 0.5 mg for adults, 0.01 mg/kg body weight for children.  anti H1 antihistamine such as chlorpheniramine maleate (adults 10 mg, children 0.2 mg/kg by intravenous injection over a few minutes)  intravenous hydrocortisone (adults 100 mg, children 2 mg/kg body weight).
  55. 55. Pyrogenic (endotoxin) reactions  usually develop 1-2 hours after treatment.  Symptoms include shaking chills (rigors), fever, vasodilatation and a fall in blood pressure.  Febrile convulsions may be precipitated in children  . These reactions are caused by pyrogen contamination during the manufacturing process.  Treatment - antipyretics
  56. 56. Late (serum sickness type) reactions  develop 1-12 (mean 7) days after treatment.  Clinical features include fever, nausea, vomiting, diarrhoea, itching, recurrent urticaria, arthralgia, myalgia, lymphadenopathy, periarticular swellings, mononeuritis multiplex, proteinuria with immune complex nephritis and rarely encephalopathy.
  57. 57. Treatment of serum sickness) reactions  Late (serum sickness) reactions usually respond to a 5-day course of oral antihistamine.  Patients who fail to respond in 24-48 hours should be given a 5-day course of prednisolone.  Doses: Chlorpheniramine: adults 2 mg six hourly, children 0.25 mg/kg /day in divided doses  Prednisolone: adults 5 mg six hourly, children 0.7 mg/kg/day in divided doses for 5-7 days
  58. 58. Recurrence of systemic envenoming  In patients envenomed by vipers, after an initial response to antivenom , signs of systemic envenoming may recur within 24-48 hours.  This is attributable to: (1) continuing absorption of venom from the “depot” at the site of the bite,  (2) a redistribution of venom from the tissues into the vascular space, as the result of antivenom treatment.
  59. 59. Criteria for giving more antivenom  If the blood remains incoagulable six hours after the initial dose of antivenom, the same dose should be repeated.  In patients who continue to bleed briskly, in case of deteriorating neurotoxicity or cardiovascular signs, the dose of antivenom should be repeated within 1-2 hours.
  60. 60. Neurotoxic envenoming  Anticholinesterase drugs have a variable, but potentially very useful effect in patients with neurotoxic envenoming, especially those bitten by cobras.  A trial of anticholinesterase (eg “Tensilon test”) should be performed in every patient with neurotoxic envenoming,
  61. 61. Treatment of the bitten part  should be nursed in the most comfortable position, preferably slightly elevated,  Bacterial infections - prophylactic course of penicillin (or erythromycin for penicillin- hypersensitive patients) and a single dose of gentamicin or a course of chloramphenicol,  booster dose of tetanus toxoid is recommended.  broad spectrum antibiotics for secondary bacterial infection
  62. 62.  In severe coagulopathy with thrombocytopenia causing disseminated intravascular coagulation, large quantities of fresh frozen plasma, cryoprecipitate and platelets are required if the response to antivenin is poor.  dialysis, is an effective supportive treatment for acute renal failure Supportive/ancillary treatment
  63. 63. Compartmental syndromes  Disproportionately severe pain  Weakness of intracompartmental muscles  Pain on passive stretching of intracompartmental muscles  Hypoaesthesia of areas of skin supplied by nerves running through the compartment  Obvious tenseness of the compartment on palpation  fasciotomy should not be contemplated until haemostatic abnormalities have been corrected,
  64. 64. Conclusion  It is strongly recommended that snake bite should be made a specific notifiable disease in all countries in the South East Asian region.  Community education about venomous snakes and snake bite is strongly recommended as the method most likely to succeed in preventing bites.
  65. 65. Any Questions?

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