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Telomeres and Unzipping

Mapping the path to the Fountain of
              Youth
                      By:
Technique
Using techniques from Shotgun Chromatin/DNA Mapping (SCM/SDM)
we hope to map a variety of useful DNA structures/...
3’ Overhang
       G-rich strand



                                                             F
                    Tel...
A                                           B




    C


                  Possible Unzipping Scenarios
    A.   Naked Te...
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Telomeres And Unzipping

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I made this presentation to show Kelly about my ideas regarding how I could apply Optical Tweezers with unzipping telomeric DNA

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Telomeres And Unzipping

  1. 1. Telomeres and Unzipping Mapping the path to the Fountain of Youth By:
  2. 2. Technique Using techniques from Shotgun Chromatin/DNA Mapping (SCM/SDM) we hope to map a variety of useful DNA structures/components. One such application could be to map Telomeres.
  3. 3. 3’ Overhang G-rich strand F Telomere DNA F How to unzip? Using techniques established by others, it is possible to isolate a telomere from other chromosomal DNA using cutting enzymes. We can attach the telomere fragment to Koch’s unzipping scheme like any other DNA/chromatin fragment.
  4. 4. A B C Possible Unzipping Scenarios A. Naked Telomere DNA B. T-loop with proteins (TRF1 and TRF2 shown) C. G-quadruplex structures on Naked Telomere DNA D. (Unshown) Some combination of the above.

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