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DR ANTHONY MELVIN CRASTO Ph.D
Organic Chemistry, 25yrs+exp. In
Process Research, million hits on google.
   COMPANY IS LOCATED IN NAVIMUMBAI, INDIA
   http://www.glenmark-generics.com/
   EMAIL- amcrasto@gmail.com

   Currently working with GLENMARK GENERICS LTD research centre as
    Principal Scientist, process research (bulk actives) and leading a team of
    scientists in developing APIs for regulated markets.
   This involves visualization and execution of novel routes, polymorphs,
    and developing intellectual property to protect the invention.
   This involves all aspects of synthesis in lab and commercialization on
    plant , support for DMF filing.
    Currently, involved in development of several targets for regulated
    markets. Provide support to US/European marketing team for
    developing and execution of new projects
   Process Development :-
    • Providing guidance and support for process development for challenging of patents in regulated market.
    • Design patent non-infringing scalable synthetic routes/process and scale-up of API’s
    • Bench and Pilot scale synthesis transformations in hands on
    • Optimization of the process, ie,developing industrially feasible process.
    • Preparation of PDR, filing of patent and DMF
    • Lead a group of Scientists and Group Leaders(for docs).

    Skill sets:- Technical skills:
    Synthesis:
    • Development of novel synthetic routes/process for pharmaceuticals and successful implementation of the
    technology in pilot plant
    • Conducted various reactions at laboratory and production scales.
    • Synthesized various classes of compounds.
    • Experienced to work under cGMP condition
    Documentation:
    • Literature survey: well conversant with the use of Sci Finder and Internet search techniques.
    • Operating Instruction: Preparation of scale up report (process, yield, costing, quality, specification etc.).
    • Setting of specifications: Supported analytical section for method development and establishment of
    specification for Raw Material, Intermediate and finished products.
    Soft skills:-
    • Creativity in problem solving, Highly motivated and Self-starting individual, Excellent communication
    skill,Team leader with good listening
   To carry out research and development activity in the field of
    Organic Chemistry, to make profit for the organization, motivate,
    guide & lead a team of scientists, conduct literature search,
    identify and execute new/novel routes for the synthesis, scale up
    from grams to kilo levels in lab., conduct pilot trials and assist in
    production upto ton levels. Carry out impurity profiles and assist in
    dossier writing. All the above being done keeping in mind the
    regulatory, safety, environmental issues. To keep in mind IPR
    issues and draft patents , Commercial aspects taken care are the
    time schedules, quality parameters and cost factors. All this with a
    view of non infringement and confidentiality. Simultaneously
    develop business acumen and convert to profits.file DMFS in US
    and EU, file patents and contribute to intellectual property
   1 Currently working as Principal Scientist, Process research(Bulk Actives)
    with GLENMARK PHARMACEUTICALS LTD research centre, API division
    at Mahape ,Navi Mumbai, India job involves research and development
    work on APIs from lab to commercial production, support for DMF filing,
    in the process develop novel non infringing routes and file
    patents,(dec05-present)

   2 Worked as Sr Manager R&D with Innovassynth technologies Limited,
    Khopoli, India (formerly IOC ltd) and led a team of 20 chemists for the
    custom synthesis business in the area of drugs, organic intermediates,
    specialty chemicals, flavours and fragrances, nutraceuticals and
    mettalocenes. (25 projects) This included rapid development, scale up
    and commercialization as per the needs of the foreign clients with a time
    frame.(may03-dec05----2 yrs 7 months)
   3 Worked as a Manager (R&D) at RPG Life Sciences Ltd ( formerly Searle India ltd). Thane Belapur.
    INDIA The job involved all aspects of synthesis and commercialization from research lab to
    production, including third party activities. (Oct. 1997- may2003, 5 years 6 months )

   4 Worked as an Executive, process development at German multinational Hoechst Marion
    Roussel Ltd, (NOW SANOFI-AVENTIS)Mulund, Mumbai, India in the QA dept, GMP section
    (Feb.1997 – oct. 1997, 8 months)

   5 Worked as an Executive,QA/GMP at a German multinational Hoechst Marion Roussel Ltd,
    Mulund, Mumbai, India in the Process Development Team. (Jan1993 - Jan1997, 4 years)

   6 Carried out Synthetic Research work as a Management trainee (R&D) at an American
    multinational Searle India ltd, Research and development centre, Thane, India (Now RPG Life
    Sciences Ltd) (May 1991 to Dec. 1992, 1 year 7 months)

    7 Worked as Indian Organic chemicals research fellow at UDCT Matunga, Mumbai, for PhD
    programme(organic chemistry) on the topic “ Synthesis of novel pyrethroids analogues”.
    Simultaneously did project work for IOC.(1987-1991, 4 years)
   Title:AMORPHOUS BAZEDOXIFENE               Process for the preparation of
    ACETATE AND PREPARATION                     tadalafil
    THEREOF                                    Authors: A M CRASTO
   Authors: A M CRASTO                        Ref. No: EP2004644 (A1)
   Ref. No: US 20100310870

                                               Year: 2008
    Year: 2010
   The present invention relates to
                                               Process for the preparation of
    amorphous form of bazedoxifene
    acetate and a process for the               atovaquone
    preparation thereof.                       Authors: A M CRASTO
                                               Ref. No: US20090105350
   A PROCESS FOR THE PREPARATION              Year: 2008
    OF ATOVAQUONE CRYSTALLINE
   Authors: A M CRASTO ET AL
   Ref. No: 1742/MUM/2007 A
                                              Amorphous eprosartan mesylate
    Year: 2009
   The present invention provides a            and process for the preparation
    process for the preparation of              thereof
    Atovaquone in a pure polymorphic form      Authors: A M CRASTO
    characterized by an X-ray powder           Ref. No: United States Patent
    diffraction pattern with peaks at about     Application 20080014263
    7.0, 9.7, 14.2, 14.8,...                   Year: 2007
                                                           Amorphous frovatriptan succinate and
    PROCESS FOR THE PREPARATION OF
    TADALAFIL                                                process for the preparation thereof
                                                            Authors: A M CRASTO
   Authors: A.M. CRASTO                                    Year: 2007
   Year: 2007

   A PROCESS OF PREPARATION OF                             SYNTHESIS OF NOVEL PYRETHROID
    METHANAMINE-N-[4(3,4-                                    ANALOGUES---THESIS
    DICHLOROPHENY)-3,4-DIHYDRO-1(2H)-                       Authors: A.M. CRASTO
                                                            MUMBAI UNIVERSITY, 1991
    NAPHTHALENYLIDENE                                    
   Authors: A M CRASTO ET AL                                Supervisor: PROF S . SESHADRI
   Ref. No: Application No.243/BOM/1999 A
   Year: 1999
                                                           Synthesis of Novel & Chloromethyl esters via
    A process for the preparation of
    methanamine-N-[4(3,4-dichlorophenyl)]-3,4-               Regiospecific ring opening reactions of aryl
                                                             glycidyl ethers with acid chlorides and the
    dihydro-1(2H)-naphthalenylidene, a critical              synthesis of alpha- morpholino methyl and
    intermediate in the synthesis of..................       alpha- cyano methyl esters
                                                            Authors: A. M. Crasto and S. Seshadri
                                                            Paper presented at the 3rd Research Scholars
   Heterocyclic Analogues of Pyrethroids
                                                            Meeting, Indian Chemical Society, Feb. 1991.
    Authors: A .M. Crasto and S. Seshadri                    , TIRUPATI, INDIA; 1988
   Thirteenth International Congress of
    Heterocyclic Chemistry , held at Corvallis,
    Oregon (U.S.A.) Abstract No. GE-11-129 ; 1991
A.M.CRASTO MEDICINAL CHEMISTRY
ANTHONY CRASTO GREEN CHEMISTRY
Anthony Crasto heterocyles
ANTHONY CRASTO MOLECULES
Anthony Crasto mycv
ANTHONY CRASTO ORGANIC
CHEMISTRY ANTHONY CRASTO
PHARMACEUTICALS
ANTHONY CRASTO REACTIONS
ANTHONY CRASTO REAGENTS
Anthony Crasto Scaleup
ANTHONY CRASTO SOURCING
ANTHONY CRASTO SPECTROSCOPY
Anthony Crasto Stereochemistry
ANTHONY MELVIN CRASTO ( Ph.D) アンソニー 安东尼 Энтони 안토니
     Shared with everyone in the worldANTHONY MELVIN CRASTO ,
ORGANIC CHEMISTRY RELATED LINKS/site/amcrasto/

ANTHONY MELVIN CRASTO CV Shared with everyone in the
world/site/anthonymelvincrastocv/

POLYMORPHISM IN ORGANIC CHEMISTRY Shared with everyone in the
world/site/polymorphisminorganicchemistry/

R & D for GM, VP
   アンソニー          安东尼 Энтони 안토니
    ANTHONY
   http://groups.google.com/group/organic-process-
    development
   http://www.linkedin.com/groupRegistration?gid=3554645
   http://www.researchgate.net/group/ORGANIC_PROCE
    SS_DEVELOPMENT/
   http://groupspaces.com/ORGANICPROCESSDEVELOPME
    NT2/announcements/
COPY AND PASTE THESE LINKS ON YOUR BROWSER TO GET HOLD OF SITES
 Linkedin page
 http://in.linkedin.com/in/amcrasto
 Researchgate
 http://www.researchgate.net/profile/Anthony_Crasto
  _Dr/
 SiliconIndia
 http://www.siliconindia.com/profiles/Anthony-Melvin-
  Crasto-PhD-5G2yZBSx.html
 Diigo
 http://www.diigo.com/user/amcrasto
 Mashable
 http://mashable.com/follow/people/anthony-melvin-
  crasto/
   Remember when you discriminate you are
    pumping jet feul into the flight of dreams



 THANKS

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Anthony crasto glenmark scientist, helping millions with websites

  • 1. DR ANTHONY MELVIN CRASTO Ph.D Organic Chemistry, 25yrs+exp. In Process Research, million hits on google.
  • 2. COMPANY IS LOCATED IN NAVIMUMBAI, INDIA  http://www.glenmark-generics.com/  EMAIL- amcrasto@gmail.com  Currently working with GLENMARK GENERICS LTD research centre as Principal Scientist, process research (bulk actives) and leading a team of scientists in developing APIs for regulated markets.  This involves visualization and execution of novel routes, polymorphs, and developing intellectual property to protect the invention.  This involves all aspects of synthesis in lab and commercialization on plant , support for DMF filing. Currently, involved in development of several targets for regulated markets. Provide support to US/European marketing team for developing and execution of new projects
  • 3. Process Development :- • Providing guidance and support for process development for challenging of patents in regulated market. • Design patent non-infringing scalable synthetic routes/process and scale-up of API’s • Bench and Pilot scale synthesis transformations in hands on • Optimization of the process, ie,developing industrially feasible process. • Preparation of PDR, filing of patent and DMF • Lead a group of Scientists and Group Leaders(for docs).  Skill sets:- Technical skills: Synthesis: • Development of novel synthetic routes/process for pharmaceuticals and successful implementation of the technology in pilot plant • Conducted various reactions at laboratory and production scales. • Synthesized various classes of compounds. • Experienced to work under cGMP condition Documentation: • Literature survey: well conversant with the use of Sci Finder and Internet search techniques. • Operating Instruction: Preparation of scale up report (process, yield, costing, quality, specification etc.). • Setting of specifications: Supported analytical section for method development and establishment of specification for Raw Material, Intermediate and finished products. Soft skills:- • Creativity in problem solving, Highly motivated and Self-starting individual, Excellent communication skill,Team leader with good listening
  • 4. To carry out research and development activity in the field of Organic Chemistry, to make profit for the organization, motivate, guide & lead a team of scientists, conduct literature search, identify and execute new/novel routes for the synthesis, scale up from grams to kilo levels in lab., conduct pilot trials and assist in production upto ton levels. Carry out impurity profiles and assist in dossier writing. All the above being done keeping in mind the regulatory, safety, environmental issues. To keep in mind IPR issues and draft patents , Commercial aspects taken care are the time schedules, quality parameters and cost factors. All this with a view of non infringement and confidentiality. Simultaneously develop business acumen and convert to profits.file DMFS in US and EU, file patents and contribute to intellectual property
  • 5. 1 Currently working as Principal Scientist, Process research(Bulk Actives) with GLENMARK PHARMACEUTICALS LTD research centre, API division at Mahape ,Navi Mumbai, India job involves research and development work on APIs from lab to commercial production, support for DMF filing, in the process develop novel non infringing routes and file patents,(dec05-present)  2 Worked as Sr Manager R&D with Innovassynth technologies Limited, Khopoli, India (formerly IOC ltd) and led a team of 20 chemists for the custom synthesis business in the area of drugs, organic intermediates, specialty chemicals, flavours and fragrances, nutraceuticals and mettalocenes. (25 projects) This included rapid development, scale up and commercialization as per the needs of the foreign clients with a time frame.(may03-dec05----2 yrs 7 months)
  • 6. 3 Worked as a Manager (R&D) at RPG Life Sciences Ltd ( formerly Searle India ltd). Thane Belapur. INDIA The job involved all aspects of synthesis and commercialization from research lab to production, including third party activities. (Oct. 1997- may2003, 5 years 6 months )  4 Worked as an Executive, process development at German multinational Hoechst Marion Roussel Ltd, (NOW SANOFI-AVENTIS)Mulund, Mumbai, India in the QA dept, GMP section (Feb.1997 – oct. 1997, 8 months)  5 Worked as an Executive,QA/GMP at a German multinational Hoechst Marion Roussel Ltd, Mulund, Mumbai, India in the Process Development Team. (Jan1993 - Jan1997, 4 years)  6 Carried out Synthetic Research work as a Management trainee (R&D) at an American multinational Searle India ltd, Research and development centre, Thane, India (Now RPG Life Sciences Ltd) (May 1991 to Dec. 1992, 1 year 7 months) 7 Worked as Indian Organic chemicals research fellow at UDCT Matunga, Mumbai, for PhD programme(organic chemistry) on the topic “ Synthesis of novel pyrethroids analogues”. Simultaneously did project work for IOC.(1987-1991, 4 years)
  • 7. Title:AMORPHOUS BAZEDOXIFENE  Process for the preparation of ACETATE AND PREPARATION tadalafil THEREOF  Authors: A M CRASTO  Authors: A M CRASTO  Ref. No: EP2004644 (A1)  Ref. No: US 20100310870   Year: 2008 Year: 2010  The present invention relates to  Process for the preparation of amorphous form of bazedoxifene acetate and a process for the atovaquone preparation thereof.  Authors: A M CRASTO  Ref. No: US20090105350  A PROCESS FOR THE PREPARATION  Year: 2008 OF ATOVAQUONE CRYSTALLINE  Authors: A M CRASTO ET AL  Ref. No: 1742/MUM/2007 A   Amorphous eprosartan mesylate Year: 2009  The present invention provides a and process for the preparation process for the preparation of thereof Atovaquone in a pure polymorphic form  Authors: A M CRASTO characterized by an X-ray powder  Ref. No: United States Patent diffraction pattern with peaks at about Application 20080014263 7.0, 9.7, 14.2, 14.8,...  Year: 2007
  • 8.  Amorphous frovatriptan succinate and PROCESS FOR THE PREPARATION OF TADALAFIL process for the preparation thereof  Authors: A M CRASTO  Authors: A.M. CRASTO  Year: 2007  Year: 2007  A PROCESS OF PREPARATION OF  SYNTHESIS OF NOVEL PYRETHROID METHANAMINE-N-[4(3,4- ANALOGUES---THESIS DICHLOROPHENY)-3,4-DIHYDRO-1(2H)-  Authors: A.M. CRASTO  MUMBAI UNIVERSITY, 1991 NAPHTHALENYLIDENE   Authors: A M CRASTO ET AL Supervisor: PROF S . SESHADRI  Ref. No: Application No.243/BOM/1999 A  Year: 1999   Synthesis of Novel & Chloromethyl esters via A process for the preparation of methanamine-N-[4(3,4-dichlorophenyl)]-3,4- Regiospecific ring opening reactions of aryl glycidyl ethers with acid chlorides and the dihydro-1(2H)-naphthalenylidene, a critical synthesis of alpha- morpholino methyl and intermediate in the synthesis of.................. alpha- cyano methyl esters  Authors: A. M. Crasto and S. Seshadri  Paper presented at the 3rd Research Scholars  Heterocyclic Analogues of Pyrethroids  Meeting, Indian Chemical Society, Feb. 1991. Authors: A .M. Crasto and S. Seshadri , TIRUPATI, INDIA; 1988  Thirteenth International Congress of Heterocyclic Chemistry , held at Corvallis, Oregon (U.S.A.) Abstract No. GE-11-129 ; 1991
  • 9. A.M.CRASTO MEDICINAL CHEMISTRY ANTHONY CRASTO GREEN CHEMISTRY Anthony Crasto heterocyles ANTHONY CRASTO MOLECULES Anthony Crasto mycv ANTHONY CRASTO ORGANIC CHEMISTRY ANTHONY CRASTO PHARMACEUTICALS ANTHONY CRASTO REACTIONS ANTHONY CRASTO REAGENTS Anthony Crasto Scaleup ANTHONY CRASTO SOURCING ANTHONY CRASTO SPECTROSCOPY Anthony Crasto Stereochemistry
  • 10. ANTHONY MELVIN CRASTO ( Ph.D) アンソニー 安东尼 Энтони 안토니 Shared with everyone in the worldANTHONY MELVIN CRASTO , ORGANIC CHEMISTRY RELATED LINKS/site/amcrasto/ ANTHONY MELVIN CRASTO CV Shared with everyone in the world/site/anthonymelvincrastocv/ POLYMORPHISM IN ORGANIC CHEMISTRY Shared with everyone in the world/site/polymorphisminorganicchemistry/ R & D for GM, VP
  • 11. アンソニー 安东尼 Энтони 안토니 ANTHONY  http://groups.google.com/group/organic-process- development  http://www.linkedin.com/groupRegistration?gid=3554645  http://www.researchgate.net/group/ORGANIC_PROCE SS_DEVELOPMENT/  http://groupspaces.com/ORGANICPROCESSDEVELOPME NT2/announcements/ COPY AND PASTE THESE LINKS ON YOUR BROWSER TO GET HOLD OF SITES
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  • 13.  Linkedin page  http://in.linkedin.com/in/amcrasto  Researchgate  http://www.researchgate.net/profile/Anthony_Crasto _Dr/  SiliconIndia  http://www.siliconindia.com/profiles/Anthony-Melvin- Crasto-PhD-5G2yZBSx.html  Diigo  http://www.diigo.com/user/amcrasto  Mashable  http://mashable.com/follow/people/anthony-melvin- crasto/
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  • 20. Remember when you discriminate you are pumping jet feul into the flight of dreams  THANKS