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Policy Directive
Ministry of Health, NSW
73 Miller Street North Sydney NSW 2060
Locked Mail Bag 961 North Sydney NSW 2059
Telephone (02) 9391 9000 Fax (02) 9391 9101
http://www.health.nsw.gov.au/policies/
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Children and Infants - Acute Management of Croup
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Document Number PD2010_053
Publication date 25-Aug-2010
Functional Sub group Clinical/ Patient Services - Baby and child
Clinical/ Patient Services - Medical Treatment
Summary Basic clinical practice guidelines for the acute treatment of infants and
children with croup.
Replaces Doc. No. Children and Infants with Croup - Acute Management [PD2005_392]
Author Branch NSW Kids and Families
Branch contact NSW Kids & Families 9391 9503
Applies to Area Health Services/Chief Executive Governed Statutory Health
Corporation, Board Governed Statutory Health Corporations, Affiliated
Health Organisations, Affiliated Health Organisations - Declared,
Community Health Centres, Government Medical Officers, NSW
Ambulance Service, Public Hospitals
Audience Emergency Departments, Paediatric Units
Distributed to Public Health System, Divisions of General Practice, Government
Medical Officers, NSW Ambulance Service, Private Hospitals and Day
Procedure Centres, Tertiary Education Institutes
Review date 25-Aug-2017
Policy Manual Patient Matters
File No.
Status Active
Director-General
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This Policy Directive may be varied, withdrawn or replaced at any time. Compliance with this directive is mandatory
for NSW Health and is a condition of subsidy for public health organisations.
POLICY STATEMENT
PD2010_053 Issue date: August 2010 Page 1 of 1
INFANTS AND CHILDREN: ACUTE MANAGEMENT OF CROUP
PURPOSE
The infants and children: acute management of croup clinical practice guideline
(attached) has been developed to provide direction to clinicians and is aimed at
achieving the best possible paediatric care in all parts of the state.
The clinical practice guideline was prepared for the NSW Department of Health by an
expert clinical reference group under the auspice of the state wide Paediatric Clinical
Practice Guideline Steering Group.
MANDATORY REQUIREMENTS
This policy applies to all facilities where paediatric patients are managed. It requires all
Health Services to have local guidelines/protocols based on the attached clinical
practice guideline in place in all hospitals and facilities likely to be required to assess or
manage children with croup.
The clinical practice guideline reflects what is currently regarded as a safe and
appropriate approach to the acute management of croup in infants and children.
However, as in any clinical situation there may be factors which cannot be covered by a
single set of guidelines. This document should be used as a guide, rather than as a
complete authoritative statement of procedures to be followed in respect of each
individual presentation. It does not replace the need for the application of clinical
judgement to each individual presentation.
IMPLEMENTATION
Chief Executives must ensure:
 Local protocols are developed based on the infants and children: acute
management of croup clinical practice guideline.
 Local protocols are in place in all hospitals and facilities likely to be required to
assess or manage paediatric patients with croup.
 Ensure that all staff treating paediatric patients are educated in the use of the
locally developed paediatric protocols.
Directors of Clinical Governance are required to inform relevant clinical staff treating
paediatric patients of the revised protocols.
REVISION HISTORY
Version Approved by Amendment notes
December 2004
(PD2005_392)
Director-General New policy
August 2010
(PD2010_053)
Deputy Director-General
Population Health
Rescinds PD2005_392. Second edition of the clinical
practice guidelines.
ATTACHMENT
1. Infants and Children: Acute Management of Croup – Clinical Practice Guideline.
Infants and Children:
Acute Management of Croup
second edition
CLINICAL PRACTICE GUIDELINES
NSW DEPARTMENT OF HEALTH
73 Miller Street
North Sydney NSW 2060
Tel. (02) 9391 9000
Fax. (02) 9391 9101
www.health.nsw.gov.au
This work is copyright. It may be reproduced in whole or part for study or training
purposes subject to the inclusion of an acknowledgement of the source. It may not be
reproduced for commercial usage or sale. Reproduction for purposes other than those
indicated above requires written permission from the NSW Department of Health.
This Clinical Practice Guideline booklet is extracted from the PD2010_053 and as a
result, this booklet may be varied, withdrawn or replaced at any time. Compliance with
the information in this booklet is mandatory for NSW Health.
© NSW Department of Health 2010
SHPN (SSD) 100062
ISBN 978-1-74187-541-6
For further copies of this document please contact:
Better Health Centre – Publications Warehouse
PO Box 672
North Ryde BC, NSW 2113
Tel.  (02) 9887 5450
Fax.  (02) 9887 5452
Email. bhc@nsccahs.nsw.gov.au
Information Production and Distribution
Tel. (02) 9391 9470
Further copies of this document can be downloaded
from the NSW Health website: www.health.nsw.gov.au
A revision of this document is due in 2012.
August 2010 - second edition
NSW Health Infants and Children – Acute Management of Croup PAGE 1
Introduction................................................................................................. 3
Changes from Previous Clinical Practice Guideline................................. 4
Overview...................................................................................................... 5
What is Croup?............................................................................................ 5
What is not Croup?..................................................................................... 5
Distinguishing Viral from Spasmodic Croup............................................. 6
Assessment of Severity.............................................................................. 6
Assessing the Need for Treatment.........................................................................7
Factors Increasing Likelihood of Hospital Admission.............................. 7
Mild Airway Obstruction............................................................................. 7
Moderate Airway Obstruction.................................................................... 7
Progression from Moderate to Severe Airway Obstruction..................... 8
Severe Airway Obstruction......................................................................... 8
Oximetry...................................................................................................... 8
Clinical Scoring Systems............................................................................ 8
Lateral Airways X-ray.................................................................................. 9
Chest Radiograph (CXR)............................................................................. 9
Which Treatment is Appropriate?.............................................................. 9
Contents
PAGE 2 NSW Health Infants and Children – Acute Management of Croup
Evidence Based Treatment Options.......................................................... 9
Non Pharmacological: Steam Inhalation.................................................................9
Oxygen............................................................................................................... 10
Systemic Corticosteroids...................................................................................... 10
Nebulised Adrenaline........................................................................................... 11
Inhaled Corticosteroids........................................................................................ 12
Summary of Evidence Based Treatment Options....................................12
Causes of Upper Airway Obstruction (Table 1)........................................13
Evidence Base of Recommendations (Table 2)........................................13
Pharmacological Treatment of Croup .
in the Emergency Department (Table 3)...................................................15
Summary of Croup Management..............................................................14
Diagnosis............................................................................................................. 14
Assessment......................................................................................................... 14
Treatment............................................................................................................ 14
Likelihood of Admission to Hospital..................................................................... 16
Considerations for Transfer to Paediatric Hospital................................................. 16
Clinical Assessment Stridor/Respiratory Distress .
Flow Diagram (Figure 1).............................................................................17
Appendices................................................................................................18
Appendix 1: References....................................................................................... 18
Appendix 2: Parent Information........................................................................... 20
Appendix 3: Resources........................................................................................ 20
Appendix 4: Working Party members.................................................................. 21
NSW Health Infants and Children – Acute Management of Croup PAGE 3
Introduction
These Guidelines are aimed at achieving
the best possible paediatric care in all
parts of the State. The document should
not be seen as a stringent set of rules
to be applied without the clinical input
and discretion of the managing
professionals. Each patient should be
individually evaluated and a decision made
as to appropriate management in order
to achieve the best clinical outcome.
The formal definition of clinical practice
guidelines comes from the National
|Health and Medical Research Council:
‘systematically developed statements to
assist practitioner and patient decisions
about appropriate health care for specific
clinical circumstances.’ (National Health
and Medical Research Council “A Guide
to the Development, implementation
and evaluation of Clinical Practice
Guidelines”, Endorsed 16 November
1998, available from www.nhmrc.gov.
au/publications/synopses/cp30syn.htm)
It should be noted that this document
reflects what is currently regarded as a
safe and appropriate approach to care.
However, as in any clinical situation there
may be factors which cannot be covered
by a single set of guidelines, this
document should be used as a guide,
rather than as a complete authoritative
statement of procedures to be followed
in respect of each individual presentation.
It does not replace the need for the
application of clinical judgment to each
individual presentation.
This document represents basic clinical
practice guidelines for the acute
management of croup in infants and
children. Further information may be
required in practice; suitable widely
available resources are included as
Appendix 3.
Each Area Health Service is responsible
for ensuring that local protocols based
on these guidelines are developed. Area
Health Services are also responsible for
ensuring that all staff treating paediatric
patients are educated in the use of the
locally developed paediatric guidelines
and protocols.
In the interests of patient care it is critical
that contemporaneous, accurate and
complete documentation is maintained
during the course of patient management
from arrival to discharge.
Parental anxiety should not be
discounted: it is often of significance
even if the child does not appear
especially unwell.
PAGE 4 NSW Health Infants and Children – Acute Management of Croup
Following a literature review new evidence
was found which has resulted in minor
changes to the document and flow chart.
The changes are outlined below.
1. Regarding the choice of corticosteroid,
there are two studies comparing
dexamethasone with prednisolone both
have showed equivalent initial clinical
response25
but a higher representation
rate with prednisolone24
. Both studies
provide level E2 evidence. From this
the current recommendation of
dexamethasone OR prednisolone can
be left as is on the flow chart; however
this information has been added to
page 11 “Systemic Corticosteroids”.
2. No difference was found between
oral dosing versus intramuscular
dosing of dexamethasone in moderate
croup (Pediatrics 2000, Rittichier).25,E2
This has been added to the last dot
point page 11 regarding systemic
corticosteroids
3.Subglottic haemangioma has been
added to Table 1: Causes of upper
airway obstruction, in the laryngeal/
subglottic column. An additional
sentence has also been added:
Changes from Previous Clinical
Practice Guideline
“Subglottic haemangioma should be
considered as an alternative diagnosis to
croup particularly in the first 6 months
of life as it can also respond to
corticosteroid therapy.”
4. Changes have been made to the
algorithm. Along the life threatening
pathway “find the most experienced
person to intubate child urgently” has
been changed to “urgently find the
most experienced person to intubate
child if required”. Also dot point added
‘Systemic corticosteroids should be
given - after assistance with airway
management has arrived.’ “Consider
intubation” has been moved from
box on using adrenaline and steroids
and an arrow added to now read “?
Improvement “ No - “consider
intubation” refer to pg 17.
5. In the Inhaled corticosteroids section
on page 12 add a dot point to reflect
there was “no advantage in combining
inhaled budesonide with oral
dexamethasone”.27,E2
6. In the section titled Evidence base for
treatment added “Heliox has no proven
benefit over nebulised adrenaline”.26,E3
NSW Health Infants and Children – Acute Management of Croup PAGE 5
Overview
n	 Croup is a common cause of upper
airway obstruction in young children.1
It is usually mild and self-limiting,
though occasionally it may cause
severe respiratory obstruction.
n	 Before the widespread use of
corticosteroids, studies reported that
as many as 31% of patients with croup
required hospitalisation2
and 1.7%
required endotracheal intubation.3
n	 Acceptance of the use of
corticosteroids for the treatment
of croup for the last decade has
dramatically reduced the number
of patients requiring admission
to hospital and endotracheal
intubation.4
n	 The differential diagnosis of
upper airway obstruction should
be considered before presuming
that the child has croup (Table 1).
What is Croup?
Croup, also known as “laryngotracheo-
bronchitis”, is the clinical syndrome
of a hoarse voice, barking cough and
inspiratory stridor.1,4
It is usually caused
by a viral infection of the upper airway
that results in inflammation of the larynx,
trachea and bronchi, thereby
compromising airflow through the
proximal airway. A number of viruses
may cause croup, although the most
common are parainfluenza 1 and 2
and respiratory syncytial viruses.1, 3, 4
It mostly affects children between 6
and 36 months, although may occur
in older children.
What is not Croup?
There are a number of structural and
infective conditions that cause upper
airway obstruction. These may be thought
of anatomically (Table 1). There are
three factors to consider when deciding
whether the presence of stridor and use
of accessory muscles of respiration relate
to croup or an alternative diagnosis:
Age of the Child
n	 A child less than 3 months of age is
more likely to have a structural airway
problem (e.g. Laryngomalacia) with or
without an intercurrent viral infection.
Similarly, Tracheomalacia may present
with a brassy cough and variable stridor.
PAGE 6 NSW Health Infants and Children – Acute Management of Croup
n	 A child between 1 and 3 years
with the acute onset of respiratory
difficulty without fever may have an
inhaled foreign body (tracheal or
oesophageal). Bronchial foreign bodies
will usually have an associated
localised expiratory wheeze (rather
than inspiratory stridor) and may have
evidence of air trapping on an
expiratory chest radiograph below the
level of obstruction (Ball-valve effect).
n	 Subglottic haemangioma should
be considered as an alternative
diagnosis to croup particularly in the
first 6 months of life as it can also
respond to corticosteroid therapy.
Character of the Stridor
n	 The combination of inspiratory
and expiratory stridor increases
the likelihood of an underlying fixed
tracheal obstruction (e.g. acquired
subglottic stenosis in a preterm infant
that was ventilated via an endotracheal
tube for a lengthy period) which will
need urgent assessment by a
paediatrician.
Toxicity of the Child
n	 Children with croup do not appear
toxic (pale, very febrile and poorly
perfused). This is more commonly seen
in bacterial tracheitis (usually staph
aureus) or epiglottitis (HiB).
Distinguishing Viral .
From Spasmodic Croup
The sub classification of the aetiology
of croup is of limited significance when
assessing a patient with acute upper
airway obstruction, as it is the degree
of airway obstruction that will determine
treatment.1, 5, 6
Typically, viral croup
develops over days with a concurrent
typical coryzal illness and the symptoms
of airway obstruction disappear over
3-5 days.1, 3-5
Conversely, spasmodic croup
is said to be more common in atopic,
older children.1, 5
Spasmodic croup comes
on rapidly overnight in children who were
perfectly well when they went to sleep.1
Spasmodic croup often runs a shorter
clinical course.1, 4
Assessment of Severity
Although infrequent, severe airway
obstruction is the major clinical concern
in croup. Assessment of the degree
of airway obstruction is, therefore, the
most important aspect of assessment.
It relies almost always on clinical signs.
Because airway obstruction in croup can
worsen rapidly, repeated careful clinical
assessment is essential.
NSW Health Infants and Children – Acute Management of Croup PAGE 7
Assessing the Need
for Treatment in Croup:
1. General appearance. A child who
is agitated appears to be tiring from
the effort of breathing or has a
decreasing level of consciousness
needs to be closely monitored.
2. Degree of respiratory distress.
The presence of stridor at rest, tracheal
tug, chest wall retractions, changing
respiratory rate and pulse rate or
palpable paradox indicates treatment
is necessary.
3. Cyanosis or extreme pallor indicates
the need for immediate treatment.
4. Oxygen desaturation [SaO2 90%]
as indicated by oximetry is a LATE sign
and unreliable indication of croup
severity.7
Factors Increasing
the Likelihood
of Hospital Admission
1. History of severe obstruction prior
to presentation
2. History of previous severe croup
or known structural airway anomaly
(e.g. Subglottic stenosis)
3. Age less than 6 months
4. Degree of respiratory distress (stridor
at rest is an indication for admission)
5. Fluid intake
6. Parental anxiety
7. Proximity of home to the hospital.
Consideration should also be given
to access to transport.
8. Representation to the Emergency
Department within 24 hours
9. Uncertain diagnosis.
Mild Airway Obstruction
Mild airway obstruction can be assumed
when the child appears to be happy
and is prepared to drink, eat, play and
take an interest in the surroundings. There
may be mild chest wall retractions and
mild tachycardia, but stridor at rest will
not be present. The parent/caregiver
should be reassured, given an explanation
that if the signs were to progress over
the next 24-48 hours then they should
return to their general practitioner,
paediatrician or to hospital for review.
Moderate Airway Obstruction
Moderate airway obstruction is indicated
by persisting stridor at rest, chest wall
retractions, use of the accessory muscles
of respiration and increasing heart rate.
The child can be placated and is
interactive with people and surroundings.
The child will need systemic
corticosteroids and observation for a
minimum of 4 hours.
PAGE 8 NSW Health Infants and Children – Acute Management of Croup
If the child continues to have stridor
at rest, then further treatment will be
considered with prolonged observation
in the Emergency Department or
admission to hospital.
Progression From Moderate
to Severe Obstruction
The child may begin to appear worried,
preoccupied or tired. The child may
sleep for short periods. This child will
require close, continuing observation
in the Emergency Department/hospital,
treatment with systemic corticosteroids
and nebulised adrenaline with regular
(minimum every 30-60 minutes) clinical
review. Progression of signs will indicate
the need for medical reassessment
and consideration of further treatment
with systemic corticosteroids and
nebulised adrenaline. The child will be
admitted to hospital.
Severe Airway Obstruction
As airway obstruction increases, the
appearance will be that of increasing
tiredness and exhaustion. Marked
tachycardia is usually present. Restlessness,
agitation, irrational behaviour, decreased
conscious level, hypotonia, cyanosis and
marked pallor are late signs indicating that
dangerous airway obstruction is now
present. A soft stridor especially in the
presence of lethargy or irritability/anxiety,
tachycardia, hypotonia or pallor should be
considered a sign of imminent airway
obstruction. As air entry decreases stridor
volume decreases. The child should
not be unnecessarily disturbed other
than the immediate application of mask
oxygen with further nebulised adrenaline
as preparations are made to intubate
the child by someone skilled in paediatric
intubation (ideally with an inhalational
induction). Systemic steroids, if not
previously given, will be administered
once the airway is secured.
Oximetry
Oximetry is a routine tool used in the
Emergency Department. Oximetry can
never substitute for good clinical
assessment. It has been demonstrated
that oxygen saturation may be near
normal in severe croup and yet significantly
lowered in some children with mild to
moderate croup.7
This is presumed to
relate to lower airway disease causing
ventilation/perfusion mismatching.
Clinical Scoring Systems
Croup severity scores have been used
in hospital based clinical research studies
to assess the suitability of patients for
treatment in a standardised manner.8, 9
They give a cumulative score, grading for
the degree of stridor, retractions, air entry,
cyanosis, dyspnoea and level of
consciousness. However, they are of
limited value in ordinary clinical practice.
NSW Health Infants and Children – Acute Management of Croup PAGE 9
Lateral Airways X-ray
A lateral airways x-ray should not be
undertaken as croup is a clinical diagnosis
and no additional information in the
management of croup can be gleaned
from the x-ray. In the presence of severe
obstruction, the child may become more
agitated and the degree of obstruction
rapidly increases in an area with limited
facilities for immediate treatment.
Chest Radiograph [CXR]
A CXR is not indicated in the management
of children with uncomplicated croup.
However, it may be considered where
there is uncertainty about the diagnosis
of croup because of the presence of
additional findings on auscultation
of the chest (e.g. wheeze raising the
possibility of croup/asthma, an inhaled
foreign body or crackles raising the
possibility of a chest infection).
Which Treatment .
is Appropriate?
The most important change in the
management of croup has been the earlier
and more liberal use of systemic and
nebulised corticosteroids10-14
and nebulised
adrenaline15
in the Emergency
Department. Much work has focussed
on steroid treatment and its utility can
be seen in the levels of evidence (Table 2)
available to ascertain its effectiveness.
Evidence Based .
Treatment Options
A flow diagram is attached
as Figure 1 on page 17.
1. Non-pharmacological: .
Steam Inhalation
n	 The use of steam inhalations
for the treatment of croup has been
advocated since the nineteenth
century to “break the coughing
spasm”.5
n	 The rationale of using steam from a
kettle, or hot running water in a bath
or shower, was that humidified air
would moisten secretions and soothe
the inflamed mucosal surface of the
trachea. However attractive this may
seem, it has not been scientifically
validated.E4
n	 Two studies have attempted to
evaluate the use of humidified air
to treat croup and both were unable
to find evidence to support the
use of steam in croup. One was an
underpowered randomised control trial
(RCT) involving 16 subjects with croup
randomised to room air or a humidified
atmosphere for 12 hours in hospital.16,E3
The second trial involved only 7 subjects
who showed no improvement in
respiratory resistance when measured
after the administration of two mls of
nebulised sterile water.7
However,
the RCT included only 16 subjects and
so there remains the possibility of a
type II error.E3
PAGE 10 NSW Health Infants and Children – Acute Management of Croup
n	 It should be emphasised that the use
of steam in this situation continues to
be associated with scalds and burns in
young children.E3
2. Oxygen
n	 Oxygen is the immediate treatment
of choice for children with severe viral
croup who have considerable upper
airway obstruction with significant
oxygen desaturation [SaO2 90%].E4
n	 This therapy has not been subjected
to an RCT. It is the initial treatment
prior to the administration of
pharmacological treatment in the
hospital setting.
3. Systemic Corticosteroids
n	 The precise mechanism by which
corticosteroids exert their effect
is not known. It is presumed
to be on the basis of rapidly acting
anti-inflammatory properties or
vasoconstrictive actions in the upper
airway. Studies have used oral
dexamethasone (0.15 to 0.6 mg/kg/
dose)4,12,13
and nebulised budesonide
(2mg/dose) 9, 10, 13
in demonstrating
the efficacy of steroids against placebo
in relieving croup symptoms in the
hospital setting. A commonly used
alternative to dexamethasone is the
use of prednisone/prednisolone at a
dose of 1-2 mg/kg/dose. Most
Emergency Departments initially
prescribe oral corticosteroids because
they are inexpensive, easy to
administer and readily available.1, 4, 12
For simplicity, and to avoid confusion
when prescribing, the recommended
dose of dexamethasone is 0.3mg/kg
and prednisolone is 1mg/kg.E4
n	 Two meta-analyses3,6
have included 24
randomised controlled trials, which
have shown clinically significant
benefit at 6 and 12 hours but not 24
hours using the clinical croup scores.8,9,
E1
The quality of the studies was good,
although the studies generally had
small numbers. The possibility of a
selection bias was raised as a funnel
plot demonstrated few published
negative studies.4
n	 The use of systemic steroids has also
been associated with a significant
decrease in the number of adrenaline
nebuliser treatments required and the
average length of stay in the
Emergency Department was reduced
by 11 hours.18-20, E1
n	 The need for endotracheal intubation
has reduced and the duration of
intubation has fallen since the earlier
use of systemic corticosteroids was
advocated.1, 4, 11, 19, E2
n	 The method of delivery of corticosteroid
has been compared in a number
of trials with oral, intravenous,
intramuscular and inhaled (nebulised)
all being shown to be superior to
placebo.4,6,13, E2
NSW Health Infants and Children – Acute Management of Croup PAGE 11
n	 It has been suggested that the
preferred delivery route for the
corticosteroids should be oral or IM.19
However, other authors would argue
that the oral route should be preferred
as it is inexpensive, easy to administer
and kindest for the patient.1, 4, E4
n	 Dexamethasone with prednisolone
has been shown to have equivalent
initial clinical response23
but there
is a higher representation rate with
prednisolone. 24, E2
n	 No difference was found between oral
dosing versus intramuscular dosing of
dexamethasone in moderate croup.25, E2
4. Nebulised Adrenaline
n	 A child with persisting inspiratory
stridor at rest and marked chest wall
retractions has severe croup. Such
a child need not be centrally cyanosed
to be severely obstructed and should
receive immediate treatment with
nebulised adrenaline (1:1000
concentrations at a dose of 0.5 ml/kg
of body weight to a maximum dose
of 5 ml delivered undiluted in the
nebuliser bowl). This dose should be
administered as soon as the adrenaline
becomes available. In addition to the
adrenaline, a dose of oral
corticosteroid (dexamethasone or
prednisone) should be administered.
The child should be reassessed
regularly.
n	 It has been suggested that nebulised
adrenaline (1:1000 concentration)
reduces bronchial and tracheal
epithelial vascular permeability thereby
decreasing airway oedema, which
results in an increase in the airway
radius and improved airflow.4,10, E4
n	 The standard dose of adrenaline is
5 ml of 1:1000 adrenaline delivered
undiluted in a nebuliser bowl is
for a 10 kg child. Smaller children
have a dose of 0.5mls of 1:1000
adrenaline per kg of body weight up
to a maximum dose of 5mls.1, 10, E1
n	 The onset of action is clinically rapid
with double blinded, randomised
controlled trials documenting a fall
in croup symptom scores within
30 minutes.10, 21, E2
n	 The duration of effect is approximately
2 hours.1, 4, E2
However, with more
severe croup, the same dose may need
to be repeated.1
n	 The need for several doses of
nebulised adrenaline in a short period
of time highlights the need to consider
urgent transfer to a paediatric centre
and/or the need for intubation.1, E4
n	 Relative contraindication in children
with ventricular outflow tract
obstruction (e.g. Tetralogy of Fallot).
Airway obstruction must take
precedent over any potential
detrimental effect that adrenaline
may have in this condition.
n	 Heliox has no proven benefit over
nebulised adrenaline.26, E3
PAGE 12 NSW Health Infants and Children – Acute Management of Croup
5. Inhaled Corticosteroids
n	 The use of 2mg to 4mg of nebulised
budesonide to treat croup attracted
attention during the 1990s. It has
been shown to be efficacious in
treating croup.9, 11, 12, E2
n	 It has an action of onset within 30
minutes,9
which compares favourably
with systemically administered
corticosteroids that have an effect
within 1 hour.1,4,12, E2
n	 It has been shown that there
is no advantage in combining
inhaled budesonide with oral
dexamethasone.27, E2
Summary of Evidence Based
Treatment Options
Over the last decade, considerable
evidence has accumulated from well-
designed clinical trials to support the more
liberal use of corticosteroids in the
management of children with croup
presenting to Emergency Departments.
The main points for the management of
croup in NSW currently are:
n	 Mild croup does not need
pharmacological treatment.E4
n	 There is no RCT evidence to support
the use of mist therapy.E3
n	 Children with croup who demonstrate
stridor and chest wall retractions
should receive corticosteroids.E4
n	 Whilst oral, intravenous, intramuscular
and nebulised corticosteroids are
efficacious, the use of oral
corticosteroids is kindest to the
patient, easy to administer and
inexpensive.E1
n	 The treatment of moderately severe
croup will usually involve the use of
nebulised adrenaline, and systemic
corticosteroids.E2
n	 The need for transfer to a paediatric
centre is based upon age of the
child, presence of predisposing
conditions (e.g. subglottic stenosis),
severity of the illness, response to
treatment and level of expertise
available at the hospital.E4
n	 A child with an unstable airway/severe
croup will require a medical escort
for transfer to a centre with paediatric
supervision.
n	 Further advice about the management
of croup is available through the
emergency physician, paediatrician or
ICU specialist on call for the hospital.
n	 If transfer to a paediatric centre
is indicated, then the Neonatal
and paediatric Emergency Transport
service (NETS) can be contacted
(1300 36 2500) to facilitate
the transfer and provide liaison with
expert advice in one of the three
NSW paediatric teaching hospitals.
It is useful to provide the parent/
caregiver of a child with croup
with a parent fact sheet (see pg 20)
on discharge from the Emergency
Department together with written
follow-up arrangements for review
by their general practitioner.
NSW Health Infants and Children – Acute Management of Croup PAGE 13
Table 1: Causes of Upper Airway Obstruction
Supraglottic Laryngeal/ Subglottic Tracheal
Acute tonsillar enlargement
bacterial/EBV
Viral croup Trauma (haematoma)
Epiglottitis (rare) Spasmodic croup Tumour (anterior mediastinal
lymphoma)
Retropharyngeal abscess Bacterial tracheitis Foreign body (oesophageal/
tracheal)
Foreign body Foreign body Tracheomalacia (particularly
in Trisomy21
)
Acute angioedema Diphtheria
Thermal/chemical injury
Intubation trauma
Laryngospasm (neural,
hypocalcaemia, associated
with reflux)
Subglottic haemangioma
Laryngomalacia (particularly
in Trisomy21)
Table 2: Evidence Base of Recommendations
The recommendations are based on the following levels of evidence, simplified from
the NHMRC’s “Quality of evidence ratings.”22
E1 Level 1: Systematic review or meta-analysis of all relevant randomised
controlled trials (RCTs).
E2 Level 2: Well designed RCTs.
E3 Level 3: Well designed cohort or case-control studies.
E4 Level 4: Consensus opinion of authors.
PAGE 14 NSW Health Infants and Children – Acute Management of Croup
Diagnosis
Croup is a clinical syndrome of hoarse
voice, barking cough and inspiratory
stridor in young children. It may be
viral or “spasmodic” but treatment is
the same. The need for treatment is
determined by the severity of proximal
airway obstruction.
Assessment
Croup may be classified as mild, moderate
or severe depending on the presence of
stridor and the degree of breathing
difficulty. Mild croup includes patients
with a barking cough without persisting
stridor at rest. Moderate croup includes
all patients with stridor at rest, tracheal
tug and chest wall recession. Severe
croup includes patients with persisting
stridor at rest and marked tracheal tug
and chest wall recession that may appear
apathetic or restless. A soft stridor
especially in the presence of lethargy or
irritability/anxiety, tachycardia, hypotonia
or pallor should be considered a sign of
imminent airway obstruction. As air entry
decreases stridor volume decreases.
Oximetry is not a reliable marker of
severity in croup.
Treatment
Mild Croup: Does not need
pharmacological treatment,E4
can be
managed at home and does not benefit
from mist therapy.E3
Moderate Croup: Patients should receive
a single dose of oral corticosteroids.E1
Many will be observed in the Emergency
Department and discharged for follow-up
by their general practitioner or
paediatrician. Some may progress
further and need nebulised adrenaline
and a longer observation period or
hospital admission.
Moderate to Severe Croup: Treatment
will involve the use of nebulised
adrenaline and systemic corticosteroids.E2
Admission to hospital is likely.
Severe croup: In addition to nebulised
adrenaline and systemic corticosteroids,
the child may require transfer to a
paediatric centre for further management
or intubation and subsequent transfer.
A person experienced in paediatric
intubation optimally performs intubation
for croup using an inhalational
anaesthetic.
Summary of Croup Management
NSW Health Infants and Children – Acute Management of Croup PAGE 15
Table 3: Pharmacological Treatment of Croup in the Emergency Department
Medication Croup Grade Dose Notes
Systemic
corticosteroids
Moderate, severe Dexamethasone
0.3 mg/kg
OR
prednisone/
prednisolone
1mg/kg
ORAL /IV/IM
Action within
1 hour.
Repeat at 12-24
hours.
Nebulised
corticosteroids
Moderate, severe Budesonide
2mg (4mls) undiluted
nebulised
Action within
30 mins
Repeat 12th hourly
for 2 days.
Consider if oral
steroids vomited
Nebulised
Adrenaline 1:1000
Moderate, severe 1:1000 Adrenaline
0.5mls/kg up to a
maximum of 5 mls
nebulised.
Action within
minutes
Give steroids also.
May need repeat
doses if severe croup.
Oxygen Severe [SaO2 90%],
Very severe with
central cyanosis
Mask with minimum
flow rate of 6L/min
via a Hudson mask.
Give nebulised
adrenaline and
systemic
corticosteroids also.
It is useful to provide the parent/caregiver
of a child with croup with a parent fact
sheet on discharge from the Emergency
Department together with written
follow-up arrangements for review by
their General Practitioner.
PAGE 16 NSW Health Infants and Children – Acute Management of Croup
After Initial Treatment,
Factors Increasing the
Likelihood of Hospital
Admission:
Severe obstruction prior to presentation,
previous severe croup or known structural
airway anomaly (e.g. subglottic stenosis),
age  6 months, stridor at rest at
presentation, poor fluid intake, marked
parental anxiety, home is a long distance
from hospital, representation to the
Emergency Department within 24 hours
and uncertainty about the diagnosis.
Considerations for Transfer .
to a Paediatric Hospital
The need for transfer to a paediatric
centre is based upon age of the child,
presence of predisposing conditions
(e.g. subglottic stenosis), severity of the
illness, response to treatment and level
of expertise available at the hospital.E4
n	 A child with an unstable airway/severe
croup will require a medical escort for
transfer to a centre with paediatric
supervision.
n	 Further advice about the management
of croup or whether to transfer
a patient is available through the
emergency physician, paediatrician,
ICU specialist on call for the
hospital or you may call Newborn
 paediatric Emergency Transport
Service (NETS NSW).
n	 If transfer to a paediatric centre
is indicated, then the Newborn
 paediatric Emergency Transport
Service NSW (NETS NSW) can
be contacted by phone on
1300 36 2500 to provide liaison with
expert advice in one of the three NSW
paediatric teaching hospitals and to
facilitate the child’s transfer.
NSW Health Infants and Children – Acute Management of Croup PAGE 17
Figure 1: Clinical Assessment: Stridor/Respiratory Distress
Croup Alternative Diagnosis?
• Inhaled foreign body
• Congenital abnormality
• Epiglottis/trachitis
• Parental explanation
and fact sheet
• No specific treatment
• Competent parents and
transport available
• Discharge
No Yes
Life Threatening Airway Obstruction?
1.	Cyanosed
2.	Decreased level of consciousness
• 100% oxygen
• Nebulised adrenaline [5mls 1:1000 undiluted in nebuliser]
• Urgently find most experienced person to intubate child if required
• NETS call (1300 36 2500)
• Inhalation induction for intubation is optimal
• Systemic corticosteroids should be given, after assistance with airway management has arrived
Moderate Croup
• Persisting stridor at rest
• Some tracheal tug and
chest wall recession
• Can be placated, interested
in surroundings
• May have cyanosis
Severe Croup
• Persisting/soft stridor at rest
• Marked tracheal tug
and chest wall recession
• Apathetic or restless/
cyanosis
• Palpable paradox
Mild Croup
• Barking cough
• Nil or intermittent stridor
• No cyanosis
Improvement
Corticosteroids
• Dexamethasone 0.3mg/kg
or
• Prednisolone 1mg/kg [oral]
or
• Nebulised Budesonide
[2mg] If oral steroids not
tolerated
• Observe  four hours
• Do not disturb child
unnecessarily
• Oxygen
• Nebulised Adrenaline
[5mls 1:1000 undiluted
in nebuliser]
Corticosteroids
• Dexamethasone 0.3mg/kg
or
• Prednisolone 1mg/kg [oral]
or
• Nebulised Budesonide
[2mg] If oral steroids not
tolerated
• Observe  four hoursYes
No• Admit/observe in
Emergency Department
• Repeat oral steroids
at 12hrs
• Parental explanation
and fact sheet
• Written follow-up
plan with GP
• Discharge when no stridor
at rest
• Explanation and fact sheet
• Inform Consultant
• Reassess/review
• Nebulised Adrenaline
[same dose as previous]
• Corticosteroids
[same dose as previous]
• Liaise with NETS
• Admit
• Consider Intubation
PARTIAL
PAGE 18 NSW Health Infants and Children – Acute Management of Croup
Appendices
Appendix One – References
1	 Fitzgerald DA, Mellis CM.
Management of acute upper airways
obstruction in children. Mod. Medicine
Aust.1995; 38:80-88.
2.	 Marx A, Torok TJ, Holman RC et al.
Pediatric Hospitalisations for croup
(Laryngotracheobronchitis): Biennal
increases associated with human
parainfluenza 1 epidemics. J Infect Dis
176: 1423-1427, 1997.
3.	 Kairys SW, Olmstead EM, O’Connor
GT. Steroid treatment of
laryngotracheitis: A meta-analysis of
the evidence from randomised trials.
Pediatrics 1989; 83: 683-693.
4.	 Klassen TP. Croup: A current
perspective. In Emergency Medicine.
Pediatric Clinics of North America
1999; 46 (6): 1167-1178.
5.	 Skolnik NS. Treatment of Croup: a
critical review. Am J Dis Child 1989;
143:1045-1049.
6.	 Ausejo M, Saenz A, Pham B et al.
The effectiveness of glucocorticoids
in treating croup: meta-analysis.
BMJ 1999; 319: 595-600.
7.	 Stoney PJ, Chakrabarti MK. Experience
of pulse oximetry in children
presenting with croup. J Laryngol Otol
1991; 105: 295-298.
8.	 Westley CR, Cotton EK, Brook JG.
Nebulized racemic epinephrine by IPPB
for the treatment of croup: A double-
blind study. Am J Dis Child 1978; 132:
484-487.
9.	 Husby S, Agertoft L, Mortensen S,
Pedersen S. Treatment of croup with
nebulized steroid (budesonide): a
double-blind, placebo controlled
study. Arch Dis Child 1993; 68:
352-355.
10.	Fitzgerald DA, Mellis CM, Johnson M ,
Cooper PC, Allen HA, Van Asperen PP
Nebulized Budesonide as effective as
Nebulized Adrenaline in Moderately
Severe Croup. Pediatrics 1996;
97:722-725.
11.	Tibbals J, Shann FA, Landau LI.
Placebo-controlled trial of
prednisolone in children intubated for
croup. Lancet 1992; 340: 745-748.
NSW Health Infants and Children – Acute Management of Croup PAGE 19
12.	Geelhoed GC, MacDonald WB. Oral
and inhaled steroids in croup: A
randomised, placebo-controlled trial.
Pediatr Pulmonol 1995; 20: 362-368.
13.	Klassen TP, Craig WR, Moher D et al.
Nebulized budesonide and oral
dexamethasone for treatment of
croup. JAMA 1998; 279: 1629-1632.
14.	Kelley PB, Simon JE. Racemic
epinephrine use in croup and
disposition. Am J Emerg Med 1992;
10: 181-183.
15.	Prendergast M, Jones JS, Hartman D.
Racemic adrenaline in the treatment of
laryngotracheitis: Can we identify
children for outpatient therapy? Am J
Emerg Med. 1994; 12: 613.
16.	Bourchier D, Dawson KP, Ferguson
DM. Humidification in viral croup: A
controlled trial. Austr. Paediatr. J 1984;
20: 289-291-616.
17.	Lenney W, Milner AD. Treatment of
acute viral croup. Arch Dis Child 1978;
53: 704-706.
18.	Cruz MN, Stewart G, Rosenberg N.
Use of dexamethasone in the
outpatient management of acute
laryngotracheitis. Pediatrics 1995; 96:
220-223.
19.	Jaffe D. The treatment of croup with
glucocorticoids. N Engl J Med 1998;
339: 498-503.
20.	Super DM, Cartelli NA, Brooks LJ et al.
A prospective randomised double-
blind study to evaluate the effect of
dexamethasone in acute
laryngotracheitis. J Pediatr 1989;
115: 323-329.
21. Waiisman Y, Klein BL, Boenning DA
et al. Prospective randomised double-
blind study comparing L-epinephrine
and racemic epinephrine aerosols in
the treatment of laryngotracheitis
(croup). Pediatrics 1992; 89: 302-306.
22. National Health and Medical Research
Council. How to use evidence:
assessment and application of
scientific evidence. Table 1.3 http://
www.nhmrc.health.gov.au/
publications/pdf/cp69.pdfo
Additional References from
November 2007 Review
23. Fifoot and Ting. EMA 2007; 19:51-58.
24. Sparrow and Geelhoed GC. Arch Dis
Child 2006; 91:580-583
25. Rittichier and Ledwith Pediatrics 2000;
106:1344-
26. Weber et al Pediatrics 2001; 107(6).
27. 1347Geelhoed GC. PEC 2005;21:
359-362.
Please note that an international literature
search was conducted in addition to the
references quotes in the previous edition.
PAGE 20 NSW Health Infants and Children – Acute Management of Croup
Appendix Two – Parent Information
A croup fact sheet jointly developed by John Hunter Children’s Hospital, Sydney Children’s
Hospital and Children’s Hospital at Westmead is available at:
www.kaleidoscope.org.au/factsheets.htm
www.sch.edu.au/health/factsheets
www.chw.edu.au/parents/factsheets
Disclaimer: The fact sheet is for educational purposes only. Please consult with your
doctor or other health professional to ensure this information is right for your child.
Appendix Three – Resources
Fuller details may be necessary in practice, especially for the management of children
with croup. Possible sources include:
NSW Health Department CIAP web site, Managing young children and infants with croup
in Hospitals at: www.ciap.health.nsw.gov.au
The Children’s Hospital at Westmead Handbook 2004 available as a book from
the Children’s Hospital at Westmead, or at www.chw.edu.au/parents/factsheets
NSW Health Infants and Children – Acute Management of Croup PAGE 21
Appendix Four – Working Party Members
Dr Mark Lee (Chair)
Paediatrician, Emergency Physician, JHCH
Dr Peter Van Asperen
Department Head, Respiratory Medicine,
CHW
Dr Peter Wyllie	
Staff Specialist, Emergency Department,
South East Sydney Illawarra Area Health
Service
Ms Leanne Crittenden
Coordinator, Northern Child
Health Network
Ms Linda Cheese
Paediatric Respiratory CNC, JHCH
Ms Sandra Babekuhl
CNC Paediatrics, Northern Child
Health Network
Ms Joanne Dungery
CNC Emergency/Critical Care Southern
Network, Greater Southern Area
Health Service
Dr Penelope Field
Department of Respiratory Medicine,
CHW
Ms Helen Gosby
Nurse Practitioner, Emergency, CHW
Dr Jodi Hilton
Paediatric Respiratory Consultant, JHCH
Dr Chris Mathews
General Practitioner, Cessnock
Ms Cheryl Nolte
NUM, Port Macquarie Base Hospital
Dr Mathew O’Meara
Director of Emergency, SCH
Dr Jessica Ryan
JMO, JHCH
Ms Narelle Stokes
Emergency, Wauchope District
Memorial Hospital
Mr Bart Cavalletto
Statewide Paediatric Coordinator,
NSW Health
CHW = The Children’s Hospital
at Westmead
JHCH = John Hunter Children’s Hospital
SCH = Sydney Children’s Hospital
PAGE 22 NSW Health Infants and Children – Acute Management of Croup
This Page Has Been Left Blank Deliberately
NSW Health Infants and Children – Acute Management of Croup PAGE 23
This Page Has Been Left Blank Deliberately
PAGE 24 NSW Health Infants and Children – Acute Management of Croup
This Page Has Been Left Blank Deliberately
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Estridor

  • 1. Policy Directive Ministry of Health, NSW 73 Miller Street North Sydney NSW 2060 Locked Mail Bag 961 North Sydney NSW 2059 Telephone (02) 9391 9000 Fax (02) 9391 9101 http://www.health.nsw.gov.au/policies/ space space Children and Infants - Acute Management of Croup space Document Number PD2010_053 Publication date 25-Aug-2010 Functional Sub group Clinical/ Patient Services - Baby and child Clinical/ Patient Services - Medical Treatment Summary Basic clinical practice guidelines for the acute treatment of infants and children with croup. Replaces Doc. No. Children and Infants with Croup - Acute Management [PD2005_392] Author Branch NSW Kids and Families Branch contact NSW Kids & Families 9391 9503 Applies to Area Health Services/Chief Executive Governed Statutory Health Corporation, Board Governed Statutory Health Corporations, Affiliated Health Organisations, Affiliated Health Organisations - Declared, Community Health Centres, Government Medical Officers, NSW Ambulance Service, Public Hospitals Audience Emergency Departments, Paediatric Units Distributed to Public Health System, Divisions of General Practice, Government Medical Officers, NSW Ambulance Service, Private Hospitals and Day Procedure Centres, Tertiary Education Institutes Review date 25-Aug-2017 Policy Manual Patient Matters File No. Status Active Director-General space This Policy Directive may be varied, withdrawn or replaced at any time. Compliance with this directive is mandatory for NSW Health and is a condition of subsidy for public health organisations.
  • 2. POLICY STATEMENT PD2010_053 Issue date: August 2010 Page 1 of 1 INFANTS AND CHILDREN: ACUTE MANAGEMENT OF CROUP PURPOSE The infants and children: acute management of croup clinical practice guideline (attached) has been developed to provide direction to clinicians and is aimed at achieving the best possible paediatric care in all parts of the state. The clinical practice guideline was prepared for the NSW Department of Health by an expert clinical reference group under the auspice of the state wide Paediatric Clinical Practice Guideline Steering Group. MANDATORY REQUIREMENTS This policy applies to all facilities where paediatric patients are managed. It requires all Health Services to have local guidelines/protocols based on the attached clinical practice guideline in place in all hospitals and facilities likely to be required to assess or manage children with croup. The clinical practice guideline reflects what is currently regarded as a safe and appropriate approach to the acute management of croup in infants and children. However, as in any clinical situation there may be factors which cannot be covered by a single set of guidelines. This document should be used as a guide, rather than as a complete authoritative statement of procedures to be followed in respect of each individual presentation. It does not replace the need for the application of clinical judgement to each individual presentation. IMPLEMENTATION Chief Executives must ensure:  Local protocols are developed based on the infants and children: acute management of croup clinical practice guideline.  Local protocols are in place in all hospitals and facilities likely to be required to assess or manage paediatric patients with croup.  Ensure that all staff treating paediatric patients are educated in the use of the locally developed paediatric protocols. Directors of Clinical Governance are required to inform relevant clinical staff treating paediatric patients of the revised protocols. REVISION HISTORY Version Approved by Amendment notes December 2004 (PD2005_392) Director-General New policy August 2010 (PD2010_053) Deputy Director-General Population Health Rescinds PD2005_392. Second edition of the clinical practice guidelines. ATTACHMENT 1. Infants and Children: Acute Management of Croup – Clinical Practice Guideline.
  • 3. Infants and Children: Acute Management of Croup second edition CLINICAL PRACTICE GUIDELINES
  • 4. NSW DEPARTMENT OF HEALTH 73 Miller Street North Sydney NSW 2060 Tel. (02) 9391 9000 Fax. (02) 9391 9101 www.health.nsw.gov.au This work is copyright. It may be reproduced in whole or part for study or training purposes subject to the inclusion of an acknowledgement of the source. It may not be reproduced for commercial usage or sale. Reproduction for purposes other than those indicated above requires written permission from the NSW Department of Health. This Clinical Practice Guideline booklet is extracted from the PD2010_053 and as a result, this booklet may be varied, withdrawn or replaced at any time. Compliance with the information in this booklet is mandatory for NSW Health. © NSW Department of Health 2010 SHPN (SSD) 100062 ISBN 978-1-74187-541-6 For further copies of this document please contact: Better Health Centre – Publications Warehouse PO Box 672 North Ryde BC, NSW 2113 Tel.  (02) 9887 5450 Fax.  (02) 9887 5452 Email. bhc@nsccahs.nsw.gov.au Information Production and Distribution Tel. (02) 9391 9470 Further copies of this document can be downloaded from the NSW Health website: www.health.nsw.gov.au A revision of this document is due in 2012. August 2010 - second edition
  • 5. NSW Health Infants and Children – Acute Management of Croup PAGE 1 Introduction................................................................................................. 3 Changes from Previous Clinical Practice Guideline................................. 4 Overview...................................................................................................... 5 What is Croup?............................................................................................ 5 What is not Croup?..................................................................................... 5 Distinguishing Viral from Spasmodic Croup............................................. 6 Assessment of Severity.............................................................................. 6 Assessing the Need for Treatment.........................................................................7 Factors Increasing Likelihood of Hospital Admission.............................. 7 Mild Airway Obstruction............................................................................. 7 Moderate Airway Obstruction.................................................................... 7 Progression from Moderate to Severe Airway Obstruction..................... 8 Severe Airway Obstruction......................................................................... 8 Oximetry...................................................................................................... 8 Clinical Scoring Systems............................................................................ 8 Lateral Airways X-ray.................................................................................. 9 Chest Radiograph (CXR)............................................................................. 9 Which Treatment is Appropriate?.............................................................. 9 Contents
  • 6. PAGE 2 NSW Health Infants and Children – Acute Management of Croup Evidence Based Treatment Options.......................................................... 9 Non Pharmacological: Steam Inhalation.................................................................9 Oxygen............................................................................................................... 10 Systemic Corticosteroids...................................................................................... 10 Nebulised Adrenaline........................................................................................... 11 Inhaled Corticosteroids........................................................................................ 12 Summary of Evidence Based Treatment Options....................................12 Causes of Upper Airway Obstruction (Table 1)........................................13 Evidence Base of Recommendations (Table 2)........................................13 Pharmacological Treatment of Croup . in the Emergency Department (Table 3)...................................................15 Summary of Croup Management..............................................................14 Diagnosis............................................................................................................. 14 Assessment......................................................................................................... 14 Treatment............................................................................................................ 14 Likelihood of Admission to Hospital..................................................................... 16 Considerations for Transfer to Paediatric Hospital................................................. 16 Clinical Assessment Stridor/Respiratory Distress . Flow Diagram (Figure 1).............................................................................17 Appendices................................................................................................18 Appendix 1: References....................................................................................... 18 Appendix 2: Parent Information........................................................................... 20 Appendix 3: Resources........................................................................................ 20 Appendix 4: Working Party members.................................................................. 21
  • 7. NSW Health Infants and Children – Acute Management of Croup PAGE 3 Introduction These Guidelines are aimed at achieving the best possible paediatric care in all parts of the State. The document should not be seen as a stringent set of rules to be applied without the clinical input and discretion of the managing professionals. Each patient should be individually evaluated and a decision made as to appropriate management in order to achieve the best clinical outcome. The formal definition of clinical practice guidelines comes from the National |Health and Medical Research Council: ‘systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances.’ (National Health and Medical Research Council “A Guide to the Development, implementation and evaluation of Clinical Practice Guidelines”, Endorsed 16 November 1998, available from www.nhmrc.gov. au/publications/synopses/cp30syn.htm) It should be noted that this document reflects what is currently regarded as a safe and appropriate approach to care. However, as in any clinical situation there may be factors which cannot be covered by a single set of guidelines, this document should be used as a guide, rather than as a complete authoritative statement of procedures to be followed in respect of each individual presentation. It does not replace the need for the application of clinical judgment to each individual presentation. This document represents basic clinical practice guidelines for the acute management of croup in infants and children. Further information may be required in practice; suitable widely available resources are included as Appendix 3. Each Area Health Service is responsible for ensuring that local protocols based on these guidelines are developed. Area Health Services are also responsible for ensuring that all staff treating paediatric patients are educated in the use of the locally developed paediatric guidelines and protocols. In the interests of patient care it is critical that contemporaneous, accurate and complete documentation is maintained during the course of patient management from arrival to discharge. Parental anxiety should not be discounted: it is often of significance even if the child does not appear especially unwell.
  • 8. PAGE 4 NSW Health Infants and Children – Acute Management of Croup Following a literature review new evidence was found which has resulted in minor changes to the document and flow chart. The changes are outlined below. 1. Regarding the choice of corticosteroid, there are two studies comparing dexamethasone with prednisolone both have showed equivalent initial clinical response25 but a higher representation rate with prednisolone24 . Both studies provide level E2 evidence. From this the current recommendation of dexamethasone OR prednisolone can be left as is on the flow chart; however this information has been added to page 11 “Systemic Corticosteroids”. 2. No difference was found between oral dosing versus intramuscular dosing of dexamethasone in moderate croup (Pediatrics 2000, Rittichier).25,E2 This has been added to the last dot point page 11 regarding systemic corticosteroids 3.Subglottic haemangioma has been added to Table 1: Causes of upper airway obstruction, in the laryngeal/ subglottic column. An additional sentence has also been added: Changes from Previous Clinical Practice Guideline “Subglottic haemangioma should be considered as an alternative diagnosis to croup particularly in the first 6 months of life as it can also respond to corticosteroid therapy.” 4. Changes have been made to the algorithm. Along the life threatening pathway “find the most experienced person to intubate child urgently” has been changed to “urgently find the most experienced person to intubate child if required”. Also dot point added ‘Systemic corticosteroids should be given - after assistance with airway management has arrived.’ “Consider intubation” has been moved from box on using adrenaline and steroids and an arrow added to now read “? Improvement “ No - “consider intubation” refer to pg 17. 5. In the Inhaled corticosteroids section on page 12 add a dot point to reflect there was “no advantage in combining inhaled budesonide with oral dexamethasone”.27,E2 6. In the section titled Evidence base for treatment added “Heliox has no proven benefit over nebulised adrenaline”.26,E3
  • 9. NSW Health Infants and Children – Acute Management of Croup PAGE 5 Overview n Croup is a common cause of upper airway obstruction in young children.1 It is usually mild and self-limiting, though occasionally it may cause severe respiratory obstruction. n Before the widespread use of corticosteroids, studies reported that as many as 31% of patients with croup required hospitalisation2 and 1.7% required endotracheal intubation.3 n Acceptance of the use of corticosteroids for the treatment of croup for the last decade has dramatically reduced the number of patients requiring admission to hospital and endotracheal intubation.4 n The differential diagnosis of upper airway obstruction should be considered before presuming that the child has croup (Table 1). What is Croup? Croup, also known as “laryngotracheo- bronchitis”, is the clinical syndrome of a hoarse voice, barking cough and inspiratory stridor.1,4 It is usually caused by a viral infection of the upper airway that results in inflammation of the larynx, trachea and bronchi, thereby compromising airflow through the proximal airway. A number of viruses may cause croup, although the most common are parainfluenza 1 and 2 and respiratory syncytial viruses.1, 3, 4 It mostly affects children between 6 and 36 months, although may occur in older children. What is not Croup? There are a number of structural and infective conditions that cause upper airway obstruction. These may be thought of anatomically (Table 1). There are three factors to consider when deciding whether the presence of stridor and use of accessory muscles of respiration relate to croup or an alternative diagnosis: Age of the Child n A child less than 3 months of age is more likely to have a structural airway problem (e.g. Laryngomalacia) with or without an intercurrent viral infection. Similarly, Tracheomalacia may present with a brassy cough and variable stridor.
  • 10. PAGE 6 NSW Health Infants and Children – Acute Management of Croup n A child between 1 and 3 years with the acute onset of respiratory difficulty without fever may have an inhaled foreign body (tracheal or oesophageal). Bronchial foreign bodies will usually have an associated localised expiratory wheeze (rather than inspiratory stridor) and may have evidence of air trapping on an expiratory chest radiograph below the level of obstruction (Ball-valve effect). n Subglottic haemangioma should be considered as an alternative diagnosis to croup particularly in the first 6 months of life as it can also respond to corticosteroid therapy. Character of the Stridor n The combination of inspiratory and expiratory stridor increases the likelihood of an underlying fixed tracheal obstruction (e.g. acquired subglottic stenosis in a preterm infant that was ventilated via an endotracheal tube for a lengthy period) which will need urgent assessment by a paediatrician. Toxicity of the Child n Children with croup do not appear toxic (pale, very febrile and poorly perfused). This is more commonly seen in bacterial tracheitis (usually staph aureus) or epiglottitis (HiB). Distinguishing Viral . From Spasmodic Croup The sub classification of the aetiology of croup is of limited significance when assessing a patient with acute upper airway obstruction, as it is the degree of airway obstruction that will determine treatment.1, 5, 6 Typically, viral croup develops over days with a concurrent typical coryzal illness and the symptoms of airway obstruction disappear over 3-5 days.1, 3-5 Conversely, spasmodic croup is said to be more common in atopic, older children.1, 5 Spasmodic croup comes on rapidly overnight in children who were perfectly well when they went to sleep.1 Spasmodic croup often runs a shorter clinical course.1, 4 Assessment of Severity Although infrequent, severe airway obstruction is the major clinical concern in croup. Assessment of the degree of airway obstruction is, therefore, the most important aspect of assessment. It relies almost always on clinical signs. Because airway obstruction in croup can worsen rapidly, repeated careful clinical assessment is essential.
  • 11. NSW Health Infants and Children – Acute Management of Croup PAGE 7 Assessing the Need for Treatment in Croup: 1. General appearance. A child who is agitated appears to be tiring from the effort of breathing or has a decreasing level of consciousness needs to be closely monitored. 2. Degree of respiratory distress. The presence of stridor at rest, tracheal tug, chest wall retractions, changing respiratory rate and pulse rate or palpable paradox indicates treatment is necessary. 3. Cyanosis or extreme pallor indicates the need for immediate treatment. 4. Oxygen desaturation [SaO2 90%] as indicated by oximetry is a LATE sign and unreliable indication of croup severity.7 Factors Increasing the Likelihood of Hospital Admission 1. History of severe obstruction prior to presentation 2. History of previous severe croup or known structural airway anomaly (e.g. Subglottic stenosis) 3. Age less than 6 months 4. Degree of respiratory distress (stridor at rest is an indication for admission) 5. Fluid intake 6. Parental anxiety 7. Proximity of home to the hospital. Consideration should also be given to access to transport. 8. Representation to the Emergency Department within 24 hours 9. Uncertain diagnosis. Mild Airway Obstruction Mild airway obstruction can be assumed when the child appears to be happy and is prepared to drink, eat, play and take an interest in the surroundings. There may be mild chest wall retractions and mild tachycardia, but stridor at rest will not be present. The parent/caregiver should be reassured, given an explanation that if the signs were to progress over the next 24-48 hours then they should return to their general practitioner, paediatrician or to hospital for review. Moderate Airway Obstruction Moderate airway obstruction is indicated by persisting stridor at rest, chest wall retractions, use of the accessory muscles of respiration and increasing heart rate. The child can be placated and is interactive with people and surroundings. The child will need systemic corticosteroids and observation for a minimum of 4 hours.
  • 12. PAGE 8 NSW Health Infants and Children – Acute Management of Croup If the child continues to have stridor at rest, then further treatment will be considered with prolonged observation in the Emergency Department or admission to hospital. Progression From Moderate to Severe Obstruction The child may begin to appear worried, preoccupied or tired. The child may sleep for short periods. This child will require close, continuing observation in the Emergency Department/hospital, treatment with systemic corticosteroids and nebulised adrenaline with regular (minimum every 30-60 minutes) clinical review. Progression of signs will indicate the need for medical reassessment and consideration of further treatment with systemic corticosteroids and nebulised adrenaline. The child will be admitted to hospital. Severe Airway Obstruction As airway obstruction increases, the appearance will be that of increasing tiredness and exhaustion. Marked tachycardia is usually present. Restlessness, agitation, irrational behaviour, decreased conscious level, hypotonia, cyanosis and marked pallor are late signs indicating that dangerous airway obstruction is now present. A soft stridor especially in the presence of lethargy or irritability/anxiety, tachycardia, hypotonia or pallor should be considered a sign of imminent airway obstruction. As air entry decreases stridor volume decreases. The child should not be unnecessarily disturbed other than the immediate application of mask oxygen with further nebulised adrenaline as preparations are made to intubate the child by someone skilled in paediatric intubation (ideally with an inhalational induction). Systemic steroids, if not previously given, will be administered once the airway is secured. Oximetry Oximetry is a routine tool used in the Emergency Department. Oximetry can never substitute for good clinical assessment. It has been demonstrated that oxygen saturation may be near normal in severe croup and yet significantly lowered in some children with mild to moderate croup.7 This is presumed to relate to lower airway disease causing ventilation/perfusion mismatching. Clinical Scoring Systems Croup severity scores have been used in hospital based clinical research studies to assess the suitability of patients for treatment in a standardised manner.8, 9 They give a cumulative score, grading for the degree of stridor, retractions, air entry, cyanosis, dyspnoea and level of consciousness. However, they are of limited value in ordinary clinical practice.
  • 13. NSW Health Infants and Children – Acute Management of Croup PAGE 9 Lateral Airways X-ray A lateral airways x-ray should not be undertaken as croup is a clinical diagnosis and no additional information in the management of croup can be gleaned from the x-ray. In the presence of severe obstruction, the child may become more agitated and the degree of obstruction rapidly increases in an area with limited facilities for immediate treatment. Chest Radiograph [CXR] A CXR is not indicated in the management of children with uncomplicated croup. However, it may be considered where there is uncertainty about the diagnosis of croup because of the presence of additional findings on auscultation of the chest (e.g. wheeze raising the possibility of croup/asthma, an inhaled foreign body or crackles raising the possibility of a chest infection). Which Treatment . is Appropriate? The most important change in the management of croup has been the earlier and more liberal use of systemic and nebulised corticosteroids10-14 and nebulised adrenaline15 in the Emergency Department. Much work has focussed on steroid treatment and its utility can be seen in the levels of evidence (Table 2) available to ascertain its effectiveness. Evidence Based . Treatment Options A flow diagram is attached as Figure 1 on page 17. 1. Non-pharmacological: . Steam Inhalation n The use of steam inhalations for the treatment of croup has been advocated since the nineteenth century to “break the coughing spasm”.5 n The rationale of using steam from a kettle, or hot running water in a bath or shower, was that humidified air would moisten secretions and soothe the inflamed mucosal surface of the trachea. However attractive this may seem, it has not been scientifically validated.E4 n Two studies have attempted to evaluate the use of humidified air to treat croup and both were unable to find evidence to support the use of steam in croup. One was an underpowered randomised control trial (RCT) involving 16 subjects with croup randomised to room air or a humidified atmosphere for 12 hours in hospital.16,E3 The second trial involved only 7 subjects who showed no improvement in respiratory resistance when measured after the administration of two mls of nebulised sterile water.7 However, the RCT included only 16 subjects and so there remains the possibility of a type II error.E3
  • 14. PAGE 10 NSW Health Infants and Children – Acute Management of Croup n It should be emphasised that the use of steam in this situation continues to be associated with scalds and burns in young children.E3 2. Oxygen n Oxygen is the immediate treatment of choice for children with severe viral croup who have considerable upper airway obstruction with significant oxygen desaturation [SaO2 90%].E4 n This therapy has not been subjected to an RCT. It is the initial treatment prior to the administration of pharmacological treatment in the hospital setting. 3. Systemic Corticosteroids n The precise mechanism by which corticosteroids exert their effect is not known. It is presumed to be on the basis of rapidly acting anti-inflammatory properties or vasoconstrictive actions in the upper airway. Studies have used oral dexamethasone (0.15 to 0.6 mg/kg/ dose)4,12,13 and nebulised budesonide (2mg/dose) 9, 10, 13 in demonstrating the efficacy of steroids against placebo in relieving croup symptoms in the hospital setting. A commonly used alternative to dexamethasone is the use of prednisone/prednisolone at a dose of 1-2 mg/kg/dose. Most Emergency Departments initially prescribe oral corticosteroids because they are inexpensive, easy to administer and readily available.1, 4, 12 For simplicity, and to avoid confusion when prescribing, the recommended dose of dexamethasone is 0.3mg/kg and prednisolone is 1mg/kg.E4 n Two meta-analyses3,6 have included 24 randomised controlled trials, which have shown clinically significant benefit at 6 and 12 hours but not 24 hours using the clinical croup scores.8,9, E1 The quality of the studies was good, although the studies generally had small numbers. The possibility of a selection bias was raised as a funnel plot demonstrated few published negative studies.4 n The use of systemic steroids has also been associated with a significant decrease in the number of adrenaline nebuliser treatments required and the average length of stay in the Emergency Department was reduced by 11 hours.18-20, E1 n The need for endotracheal intubation has reduced and the duration of intubation has fallen since the earlier use of systemic corticosteroids was advocated.1, 4, 11, 19, E2 n The method of delivery of corticosteroid has been compared in a number of trials with oral, intravenous, intramuscular and inhaled (nebulised) all being shown to be superior to placebo.4,6,13, E2
  • 15. NSW Health Infants and Children – Acute Management of Croup PAGE 11 n It has been suggested that the preferred delivery route for the corticosteroids should be oral or IM.19 However, other authors would argue that the oral route should be preferred as it is inexpensive, easy to administer and kindest for the patient.1, 4, E4 n Dexamethasone with prednisolone has been shown to have equivalent initial clinical response23 but there is a higher representation rate with prednisolone. 24, E2 n No difference was found between oral dosing versus intramuscular dosing of dexamethasone in moderate croup.25, E2 4. Nebulised Adrenaline n A child with persisting inspiratory stridor at rest and marked chest wall retractions has severe croup. Such a child need not be centrally cyanosed to be severely obstructed and should receive immediate treatment with nebulised adrenaline (1:1000 concentrations at a dose of 0.5 ml/kg of body weight to a maximum dose of 5 ml delivered undiluted in the nebuliser bowl). This dose should be administered as soon as the adrenaline becomes available. In addition to the adrenaline, a dose of oral corticosteroid (dexamethasone or prednisone) should be administered. The child should be reassessed regularly. n It has been suggested that nebulised adrenaline (1:1000 concentration) reduces bronchial and tracheal epithelial vascular permeability thereby decreasing airway oedema, which results in an increase in the airway radius and improved airflow.4,10, E4 n The standard dose of adrenaline is 5 ml of 1:1000 adrenaline delivered undiluted in a nebuliser bowl is for a 10 kg child. Smaller children have a dose of 0.5mls of 1:1000 adrenaline per kg of body weight up to a maximum dose of 5mls.1, 10, E1 n The onset of action is clinically rapid with double blinded, randomised controlled trials documenting a fall in croup symptom scores within 30 minutes.10, 21, E2 n The duration of effect is approximately 2 hours.1, 4, E2 However, with more severe croup, the same dose may need to be repeated.1 n The need for several doses of nebulised adrenaline in a short period of time highlights the need to consider urgent transfer to a paediatric centre and/or the need for intubation.1, E4 n Relative contraindication in children with ventricular outflow tract obstruction (e.g. Tetralogy of Fallot). Airway obstruction must take precedent over any potential detrimental effect that adrenaline may have in this condition. n Heliox has no proven benefit over nebulised adrenaline.26, E3
  • 16. PAGE 12 NSW Health Infants and Children – Acute Management of Croup 5. Inhaled Corticosteroids n The use of 2mg to 4mg of nebulised budesonide to treat croup attracted attention during the 1990s. It has been shown to be efficacious in treating croup.9, 11, 12, E2 n It has an action of onset within 30 minutes,9 which compares favourably with systemically administered corticosteroids that have an effect within 1 hour.1,4,12, E2 n It has been shown that there is no advantage in combining inhaled budesonide with oral dexamethasone.27, E2 Summary of Evidence Based Treatment Options Over the last decade, considerable evidence has accumulated from well- designed clinical trials to support the more liberal use of corticosteroids in the management of children with croup presenting to Emergency Departments. The main points for the management of croup in NSW currently are: n Mild croup does not need pharmacological treatment.E4 n There is no RCT evidence to support the use of mist therapy.E3 n Children with croup who demonstrate stridor and chest wall retractions should receive corticosteroids.E4 n Whilst oral, intravenous, intramuscular and nebulised corticosteroids are efficacious, the use of oral corticosteroids is kindest to the patient, easy to administer and inexpensive.E1 n The treatment of moderately severe croup will usually involve the use of nebulised adrenaline, and systemic corticosteroids.E2 n The need for transfer to a paediatric centre is based upon age of the child, presence of predisposing conditions (e.g. subglottic stenosis), severity of the illness, response to treatment and level of expertise available at the hospital.E4 n A child with an unstable airway/severe croup will require a medical escort for transfer to a centre with paediatric supervision. n Further advice about the management of croup is available through the emergency physician, paediatrician or ICU specialist on call for the hospital. n If transfer to a paediatric centre is indicated, then the Neonatal and paediatric Emergency Transport service (NETS) can be contacted (1300 36 2500) to facilitate the transfer and provide liaison with expert advice in one of the three NSW paediatric teaching hospitals. It is useful to provide the parent/ caregiver of a child with croup with a parent fact sheet (see pg 20) on discharge from the Emergency Department together with written follow-up arrangements for review by their general practitioner.
  • 17. NSW Health Infants and Children – Acute Management of Croup PAGE 13 Table 1: Causes of Upper Airway Obstruction Supraglottic Laryngeal/ Subglottic Tracheal Acute tonsillar enlargement bacterial/EBV Viral croup Trauma (haematoma) Epiglottitis (rare) Spasmodic croup Tumour (anterior mediastinal lymphoma) Retropharyngeal abscess Bacterial tracheitis Foreign body (oesophageal/ tracheal) Foreign body Foreign body Tracheomalacia (particularly in Trisomy21 ) Acute angioedema Diphtheria Thermal/chemical injury Intubation trauma Laryngospasm (neural, hypocalcaemia, associated with reflux) Subglottic haemangioma Laryngomalacia (particularly in Trisomy21) Table 2: Evidence Base of Recommendations The recommendations are based on the following levels of evidence, simplified from the NHMRC’s “Quality of evidence ratings.”22 E1 Level 1: Systematic review or meta-analysis of all relevant randomised controlled trials (RCTs). E2 Level 2: Well designed RCTs. E3 Level 3: Well designed cohort or case-control studies. E4 Level 4: Consensus opinion of authors.
  • 18. PAGE 14 NSW Health Infants and Children – Acute Management of Croup Diagnosis Croup is a clinical syndrome of hoarse voice, barking cough and inspiratory stridor in young children. It may be viral or “spasmodic” but treatment is the same. The need for treatment is determined by the severity of proximal airway obstruction. Assessment Croup may be classified as mild, moderate or severe depending on the presence of stridor and the degree of breathing difficulty. Mild croup includes patients with a barking cough without persisting stridor at rest. Moderate croup includes all patients with stridor at rest, tracheal tug and chest wall recession. Severe croup includes patients with persisting stridor at rest and marked tracheal tug and chest wall recession that may appear apathetic or restless. A soft stridor especially in the presence of lethargy or irritability/anxiety, tachycardia, hypotonia or pallor should be considered a sign of imminent airway obstruction. As air entry decreases stridor volume decreases. Oximetry is not a reliable marker of severity in croup. Treatment Mild Croup: Does not need pharmacological treatment,E4 can be managed at home and does not benefit from mist therapy.E3 Moderate Croup: Patients should receive a single dose of oral corticosteroids.E1 Many will be observed in the Emergency Department and discharged for follow-up by their general practitioner or paediatrician. Some may progress further and need nebulised adrenaline and a longer observation period or hospital admission. Moderate to Severe Croup: Treatment will involve the use of nebulised adrenaline and systemic corticosteroids.E2 Admission to hospital is likely. Severe croup: In addition to nebulised adrenaline and systemic corticosteroids, the child may require transfer to a paediatric centre for further management or intubation and subsequent transfer. A person experienced in paediatric intubation optimally performs intubation for croup using an inhalational anaesthetic. Summary of Croup Management
  • 19. NSW Health Infants and Children – Acute Management of Croup PAGE 15 Table 3: Pharmacological Treatment of Croup in the Emergency Department Medication Croup Grade Dose Notes Systemic corticosteroids Moderate, severe Dexamethasone 0.3 mg/kg OR prednisone/ prednisolone 1mg/kg ORAL /IV/IM Action within 1 hour. Repeat at 12-24 hours. Nebulised corticosteroids Moderate, severe Budesonide 2mg (4mls) undiluted nebulised Action within 30 mins Repeat 12th hourly for 2 days. Consider if oral steroids vomited Nebulised Adrenaline 1:1000 Moderate, severe 1:1000 Adrenaline 0.5mls/kg up to a maximum of 5 mls nebulised. Action within minutes Give steroids also. May need repeat doses if severe croup. Oxygen Severe [SaO2 90%], Very severe with central cyanosis Mask with minimum flow rate of 6L/min via a Hudson mask. Give nebulised adrenaline and systemic corticosteroids also. It is useful to provide the parent/caregiver of a child with croup with a parent fact sheet on discharge from the Emergency Department together with written follow-up arrangements for review by their General Practitioner.
  • 20. PAGE 16 NSW Health Infants and Children – Acute Management of Croup After Initial Treatment, Factors Increasing the Likelihood of Hospital Admission: Severe obstruction prior to presentation, previous severe croup or known structural airway anomaly (e.g. subglottic stenosis), age 6 months, stridor at rest at presentation, poor fluid intake, marked parental anxiety, home is a long distance from hospital, representation to the Emergency Department within 24 hours and uncertainty about the diagnosis. Considerations for Transfer . to a Paediatric Hospital The need for transfer to a paediatric centre is based upon age of the child, presence of predisposing conditions (e.g. subglottic stenosis), severity of the illness, response to treatment and level of expertise available at the hospital.E4 n A child with an unstable airway/severe croup will require a medical escort for transfer to a centre with paediatric supervision. n Further advice about the management of croup or whether to transfer a patient is available through the emergency physician, paediatrician, ICU specialist on call for the hospital or you may call Newborn paediatric Emergency Transport Service (NETS NSW). n If transfer to a paediatric centre is indicated, then the Newborn paediatric Emergency Transport Service NSW (NETS NSW) can be contacted by phone on 1300 36 2500 to provide liaison with expert advice in one of the three NSW paediatric teaching hospitals and to facilitate the child’s transfer.
  • 21. NSW Health Infants and Children – Acute Management of Croup PAGE 17 Figure 1: Clinical Assessment: Stridor/Respiratory Distress Croup Alternative Diagnosis? • Inhaled foreign body • Congenital abnormality • Epiglottis/trachitis • Parental explanation and fact sheet • No specific treatment • Competent parents and transport available • Discharge No Yes Life Threatening Airway Obstruction? 1. Cyanosed 2. Decreased level of consciousness • 100% oxygen • Nebulised adrenaline [5mls 1:1000 undiluted in nebuliser] • Urgently find most experienced person to intubate child if required • NETS call (1300 36 2500) • Inhalation induction for intubation is optimal • Systemic corticosteroids should be given, after assistance with airway management has arrived Moderate Croup • Persisting stridor at rest • Some tracheal tug and chest wall recession • Can be placated, interested in surroundings • May have cyanosis Severe Croup • Persisting/soft stridor at rest • Marked tracheal tug and chest wall recession • Apathetic or restless/ cyanosis • Palpable paradox Mild Croup • Barking cough • Nil or intermittent stridor • No cyanosis Improvement Corticosteroids • Dexamethasone 0.3mg/kg or • Prednisolone 1mg/kg [oral] or • Nebulised Budesonide [2mg] If oral steroids not tolerated • Observe four hours • Do not disturb child unnecessarily • Oxygen • Nebulised Adrenaline [5mls 1:1000 undiluted in nebuliser] Corticosteroids • Dexamethasone 0.3mg/kg or • Prednisolone 1mg/kg [oral] or • Nebulised Budesonide [2mg] If oral steroids not tolerated • Observe four hoursYes No• Admit/observe in Emergency Department • Repeat oral steroids at 12hrs • Parental explanation and fact sheet • Written follow-up plan with GP • Discharge when no stridor at rest • Explanation and fact sheet • Inform Consultant • Reassess/review • Nebulised Adrenaline [same dose as previous] • Corticosteroids [same dose as previous] • Liaise with NETS • Admit • Consider Intubation PARTIAL
  • 22. PAGE 18 NSW Health Infants and Children – Acute Management of Croup Appendices Appendix One – References 1 Fitzgerald DA, Mellis CM. Management of acute upper airways obstruction in children. Mod. Medicine Aust.1995; 38:80-88. 2. Marx A, Torok TJ, Holman RC et al. Pediatric Hospitalisations for croup (Laryngotracheobronchitis): Biennal increases associated with human parainfluenza 1 epidemics. J Infect Dis 176: 1423-1427, 1997. 3. Kairys SW, Olmstead EM, O’Connor GT. Steroid treatment of laryngotracheitis: A meta-analysis of the evidence from randomised trials. Pediatrics 1989; 83: 683-693. 4. Klassen TP. Croup: A current perspective. In Emergency Medicine. Pediatric Clinics of North America 1999; 46 (6): 1167-1178. 5. Skolnik NS. Treatment of Croup: a critical review. Am J Dis Child 1989; 143:1045-1049. 6. Ausejo M, Saenz A, Pham B et al. The effectiveness of glucocorticoids in treating croup: meta-analysis. BMJ 1999; 319: 595-600. 7. Stoney PJ, Chakrabarti MK. Experience of pulse oximetry in children presenting with croup. J Laryngol Otol 1991; 105: 295-298. 8. Westley CR, Cotton EK, Brook JG. Nebulized racemic epinephrine by IPPB for the treatment of croup: A double- blind study. Am J Dis Child 1978; 132: 484-487. 9. Husby S, Agertoft L, Mortensen S, Pedersen S. Treatment of croup with nebulized steroid (budesonide): a double-blind, placebo controlled study. Arch Dis Child 1993; 68: 352-355. 10. Fitzgerald DA, Mellis CM, Johnson M , Cooper PC, Allen HA, Van Asperen PP Nebulized Budesonide as effective as Nebulized Adrenaline in Moderately Severe Croup. Pediatrics 1996; 97:722-725. 11. Tibbals J, Shann FA, Landau LI. Placebo-controlled trial of prednisolone in children intubated for croup. Lancet 1992; 340: 745-748.
  • 23. NSW Health Infants and Children – Acute Management of Croup PAGE 19 12. Geelhoed GC, MacDonald WB. Oral and inhaled steroids in croup: A randomised, placebo-controlled trial. Pediatr Pulmonol 1995; 20: 362-368. 13. Klassen TP, Craig WR, Moher D et al. Nebulized budesonide and oral dexamethasone for treatment of croup. JAMA 1998; 279: 1629-1632. 14. Kelley PB, Simon JE. Racemic epinephrine use in croup and disposition. Am J Emerg Med 1992; 10: 181-183. 15. Prendergast M, Jones JS, Hartman D. Racemic adrenaline in the treatment of laryngotracheitis: Can we identify children for outpatient therapy? Am J Emerg Med. 1994; 12: 613. 16. Bourchier D, Dawson KP, Ferguson DM. Humidification in viral croup: A controlled trial. Austr. Paediatr. J 1984; 20: 289-291-616. 17. Lenney W, Milner AD. Treatment of acute viral croup. Arch Dis Child 1978; 53: 704-706. 18. Cruz MN, Stewart G, Rosenberg N. Use of dexamethasone in the outpatient management of acute laryngotracheitis. Pediatrics 1995; 96: 220-223. 19. Jaffe D. The treatment of croup with glucocorticoids. N Engl J Med 1998; 339: 498-503. 20. Super DM, Cartelli NA, Brooks LJ et al. A prospective randomised double- blind study to evaluate the effect of dexamethasone in acute laryngotracheitis. J Pediatr 1989; 115: 323-329. 21. Waiisman Y, Klein BL, Boenning DA et al. Prospective randomised double- blind study comparing L-epinephrine and racemic epinephrine aerosols in the treatment of laryngotracheitis (croup). Pediatrics 1992; 89: 302-306. 22. National Health and Medical Research Council. How to use evidence: assessment and application of scientific evidence. Table 1.3 http:// www.nhmrc.health.gov.au/ publications/pdf/cp69.pdfo Additional References from November 2007 Review 23. Fifoot and Ting. EMA 2007; 19:51-58. 24. Sparrow and Geelhoed GC. Arch Dis Child 2006; 91:580-583 25. Rittichier and Ledwith Pediatrics 2000; 106:1344- 26. Weber et al Pediatrics 2001; 107(6). 27. 1347Geelhoed GC. PEC 2005;21: 359-362. Please note that an international literature search was conducted in addition to the references quotes in the previous edition.
  • 24. PAGE 20 NSW Health Infants and Children – Acute Management of Croup Appendix Two – Parent Information A croup fact sheet jointly developed by John Hunter Children’s Hospital, Sydney Children’s Hospital and Children’s Hospital at Westmead is available at: www.kaleidoscope.org.au/factsheets.htm www.sch.edu.au/health/factsheets www.chw.edu.au/parents/factsheets Disclaimer: The fact sheet is for educational purposes only. Please consult with your doctor or other health professional to ensure this information is right for your child. Appendix Three – Resources Fuller details may be necessary in practice, especially for the management of children with croup. Possible sources include: NSW Health Department CIAP web site, Managing young children and infants with croup in Hospitals at: www.ciap.health.nsw.gov.au The Children’s Hospital at Westmead Handbook 2004 available as a book from the Children’s Hospital at Westmead, or at www.chw.edu.au/parents/factsheets
  • 25. NSW Health Infants and Children – Acute Management of Croup PAGE 21 Appendix Four – Working Party Members Dr Mark Lee (Chair) Paediatrician, Emergency Physician, JHCH Dr Peter Van Asperen Department Head, Respiratory Medicine, CHW Dr Peter Wyllie Staff Specialist, Emergency Department, South East Sydney Illawarra Area Health Service Ms Leanne Crittenden Coordinator, Northern Child Health Network Ms Linda Cheese Paediatric Respiratory CNC, JHCH Ms Sandra Babekuhl CNC Paediatrics, Northern Child Health Network Ms Joanne Dungery CNC Emergency/Critical Care Southern Network, Greater Southern Area Health Service Dr Penelope Field Department of Respiratory Medicine, CHW Ms Helen Gosby Nurse Practitioner, Emergency, CHW Dr Jodi Hilton Paediatric Respiratory Consultant, JHCH Dr Chris Mathews General Practitioner, Cessnock Ms Cheryl Nolte NUM, Port Macquarie Base Hospital Dr Mathew O’Meara Director of Emergency, SCH Dr Jessica Ryan JMO, JHCH Ms Narelle Stokes Emergency, Wauchope District Memorial Hospital Mr Bart Cavalletto Statewide Paediatric Coordinator, NSW Health CHW = The Children’s Hospital at Westmead JHCH = John Hunter Children’s Hospital SCH = Sydney Children’s Hospital
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