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ANTI-INFLAMMATORY AGENTS  USED IN ASTHMA AND COUGH  SUPPRESSANTSANKIT GILANIDEPT OF PHARMACOLOGY AND TOXICOLOGYNIPERA1113P...
ASTHMA An inflammatory condition in which there is  recurrent reversible airways obstruction in  response to irritant sti...
PATHOGENESIS
characterised by: inflammation of the airways bronchial hyper-reactivity reversible airways obstruction
TREATMENTBRONCHODILATORS                             ANTI-INFLAMMATORY   β-Adrenoceptor      agonists,                    ...
ANTI-INFLAMMATORY AGENTS Mainly glucocorticoids Cromoglicate and nedocromil (weak anti-  inflammatory and short duration...
Mechanism of glucocorticoids
 decrease formation of cytokines, in particular the  Th2 cytokines that recruit and activate eosinophils  and are respons...
 Corticosteroids inhibit the allergen-induced  influx of eosinophils into the lung. Glucocorticoids up-regulate β2  adre...
EXAMPLES :1) Systemic ( given orally) : Prednisone Prednisolone Methylprednisolone2) Inhaled : Beclometasone Budenosi...
Unwanted effectsSystemic : Thinning of the skin, Tendency to bruise,Osteoporosis, Muscle Weakness, Infections,Hypertension...
DRUGS FOR COUGHCOUGH : a protective reflex that removes foreign  material and secretions from the bronchi and  bronchioles...
DRUGS FOR COUGH  Pharyngeal demulcents  Expectorants (mucokinetics)  Antitussives (cough centre suppressants)  Adjuvant an...
MECHANISM OF COUGH SUPPRESSION Antitussive drugs act by an ill-defined effect in  the brain stem, depressing the cough ce...
EXAMPLES Codeine (methylmorphine) is a weak opioid  with considerably less addiction liability than  the main opioids, an...
Mechanism of glucocorticoids
Mechanism of glucocorticoids
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Mechanism of glucocorticoids

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