American Chemical Society
246th National Meeting
September 8-12, 2013
Division of Small Chemical Businesses
ABSTRACTS OF ORAL PAPERS & POSTERS
Small Business Chemistry in Motion
G. Arnold, Organizer, Presiding; Paper 1
SCHB Poster Session
G. Ruger, Organizer, Presiding; Papers 2-4
G. Ruger, Organizer; Papers 2-4
True Stories of Success from Chemical Entrepreneurs
G. Ruger, Organizer, Presiding, Papers 5-10
STEM Women in Innovation and Investing
J. Bryant, Organizer; J. Maclachlan, Organizer; J. Giordan, Presiding; Papers 11-14
Applications of Ionic Liquids from the Small Business Sector
S. Seelig, Organizer, Presiding; Papers 15-19
Biofuels in Motion
K. Andrews, Organizer, Presiding; Papers 20-22
SCHB 1 Business of science: How to turn your scientific skill set into a successful
Gianna Arnold1, Garnold@saul.com, Jacqueline L. Allen1, Elizabeth Hart Wells2, Rajesh Nair3, Linda
Sivik4. (1) Saul Ewing LLP, Baltimore, MD 21202,(2) Kurz Purdue Technology Center, West
Lafayette, IN 47906, (3) Saul Ewing LLP, Washington, DC 20006, (4) The Procter & Gamble
Company, Cincinnati, OH 45202.
Join our wide spectrum of speakers for a facilitated presentation and discussion aimed at
assisting you with the business of science. The session will begin with “Best Steps to Business
Success - and Pitfalls to Avoid,” an overview on creating a technology-based company. Further
presentation and discussion will include the elements: creating an organizational structure, various
forms of intellectual property and their use as strategic business assets, roles an expert can fill as a
consultant to an early stage company or as a scientific advisory board member, alternative forms of
compensation as a consultant, key considerations in agreements, technology transfer, industry
collaboration, and much more! This is your opportunity to ensure the success of your new or planned
SCHB 2 Ariadne: A next generation chemical inventory and ELN web application
Valentin O Rodionov, firstname.lastname@example.org.Moleculenix LLC., United States.
Keeping track of thousands of chemicals in a research lab is not a trivial task. Specialized
inventory software does exist. However, such software is often focused squarely on regulatory
compliance, and is perceived by end users as a burdensome layer of digital bureaucracy.
Laboratories in academia are especially likely to keep vital inventory records in ordinary
spreadsheets, or even on paper. Recently, we introduced Ariadne, a web application combining a
chemical inventory with an electronic lab notebook (ELN). Ariadne assigns the location of every
chemical semi-randomly, based on storage compatibility rules. The system reveals the item location
only after the item has been checked out by the user. Mandatory checkout ensures item movement is
editor, ChemWidget, to enable structure input in any web browser. This presentation will describe our
experience in developing chemical software for the modern web.
SCHB 3 Benefits of a Division of Small Chemical Businesses membership
Jennifer L Maclachlan1, email@example.com, Stan Seelig1, Mukund Chorghade1, Sharon Vercellotti1,
David Deutsch1, Joseph E Sabol1, Michael Haukaas1, Anis Rahman1, Ronald Versic1, Carlyn Burton1,
George Ruger. (1) Division of Small Chemical Businesses, Sandwich, MA 02563.
The ACS Division of Small Chemical Businesses Division (SCHB) has provided valuable member
benefits and informative programming, featuring small businesses and with resources for small
businesses, at ACS national and regional meetings, since 1977. SCHB member benefits include free
membership for the first year, listing in the SCHB website members' directory of products and services,
deeply discounted ACS national meeting expo booth space the Small Chemical Business Row,
scholarship to the ACS Leadership Courses, the opportunity to shape and direct SCHB, and, the best of
all: amazing networking opportunities in-person at ACS meetings and via SCHB's social media platforms
(ACS Network, LinkedIn, Twitter and Facebook.) Patron [corporate] membership is also available.
SCHB 4 Chemical professionals investing in chemical companies
Mark Vreeke, firstname.lastname@example.org, Sid White, Judith Giordan.Chemical Angel Network, United
The Chemical Angel Network (CaN) is a nationwide angel investing network for early stage
chemical businesses (ie. businesses with a significant chemistry component). The CaN network offers
chemists, chemical engineers, and chemical professionals a unique opportunity to participate in the
growth of companies in the chemical and related industries. In addition to possibly significant financial
upside opportunities, the CaN network encompasses several unique elements. We anticipate that a
significant number of the qualified investors will be retired or semi-retired chemical professionals. In
addition to capital, the network will draw upon the retired and semi-retired member's unique experience
and knowledge base to provide special due diligence, mentoring, contacts, and general technical
expertise. Our hope is that CaN will become the smart capital choice for early stage chemical companies.
SCHB 5 Surviving a start-up by innovation
Anis Rahman, email@example.com.Applied Research & Photonics, Harrisburg, PA 17111
In today's world the name of the game is competition. Especially when the ever-changing
world of technology is bringing the next best thing more often, making the state of the art a thing of
past more quickly. However, innovation or having a new idea alone is never sufficient to build and
survive a business. It is important to have a priori knowledge about how the new technology or the
new product will attract target users. An important question is, “why people should consider this
product?” So, the value proposition must be strong. At the same time diffusion of knowledge of the
new technology to the target population is always a challenge. More often than not, new
entrepreneurs lack the foresight, since “success” never is a straight line; as such a great deal of
lessons must be learned the hard way. Some examples will be outlined from a start-up point of view.
SCHB 6 Commercializing your research and finding focus for your start-up using the
teachings of the NSF I-Corps program
Andrew D Basner, firstname.lastname@example.org.Department of Chemistry, Syracuse University, Syracuse, NY
The National Science Foundation has supported science and engineering for many years.
Some of this research has the potential for applications in the commercial world but
commercialization is often not realized. To help foster this transition from research to a commercial
product, the National Science Foundation developed the Innovation corps program. Over the course
of an intensive 8 week program, our team talked to over 100 potential customers, defined and
validated a value proposition for clear customer segments, identified revenue strategies and models,
identified the correct channels for our technology, and met with key potential partners. The teaching
team for the NSF I-Corps helped us identify key pitfalls that are common in technology based start-
ups and led us to a single, clear, and focus scalable business model. A number of key ideas from this
program can be used by anyone who is interested in commercializing their research or by anyone
who is in the process of finding an ideal market segment to fit into.
SCHB 7 HESI: Creating science-based solutions for a sustainable, healthier world
Jennifer Young Tanir, email@example.com.ILSI Health and Environmental Sciences Institute,
Washington DC, United States.
The ILSI Health and Environmental Sciences Institute (HESI) was established in 1989 as a
global branch of the International Life Sciences Institute (ILSI) to provide an international forum to
advance the understanding of scientific issues related to human health, toxicology, risk assessment,
and the environment. With a vision of creating science-based solutions for a sustainable, healthier
world, HESI recognizes sustainability as vitally important as it identifies and resolves global health
and environmemntal issues through engagement with scientists from academia, government and
industry. As a non-profit organization, HESI provides a unique, objective forum for initiating dialogue
among scientists with different perspectives and expertise from a range of sectors including
pharmaceuticals, agricultural and industrial chemicals, personal care and consumer product, and
others. HESI's broad scientific portfolio spans translational biology, new approaches and techniques,
environmental toxicology, and risk assessment. Using a committee structure to engage scientists,
supported by expert staff with advanced scientific degrees, HESI enables hundreds of scientists to
work together to address public health needs, from 49 corporate sponsors, 70 universities, 32
government agencies (international, national, and state), foundations and non-governmental
organizations, by a financially viable model. This presentation will highlight several of HESI's success
SCHB 8 Building a microencapsulation company: A 35 year history of controlled release
Ronald J Versic, Rversic@RTDodge.com Ronald T. Dodge Company, Dayton, OH 45459.
In the spring of 1979 the author started out with USD 500 and a desire to build a company
based upon the principles of (1) multiple microencapsulation capabilities, a desire to (2) manufacture
microcapsules and (3) scientific soundness. The results for this international company are described
along with the difficult path to the current business status.
SCHB 9 History of NanoVir, LLC, a drug discovery company supported by the NIH and
grown partly through interactions with academia
James K Bashkin, firstname.lastname@example.org Department of Chemistry, NanoVir, LLC, Saint Louis, MO
63121, United States Department of Chemistry & Biochemistry, Center for Nanoscience, University of
Missouri-St. Louis, Saint Louis, MO 63121.
NanoVir LLC is a company that was started jointly by a chemist (myself) located in St. Louis
MO and a biologist (Dr. Chris Fisher) located in Kalamazoo MI. Our purpose was the discovery and
development of antiviral agents suitable for therapy against high-risk, cancer-causing human
papillomavirus (HPV). In order create the company, we co-wrote a Phase I small business proposal
to the National Institutes of Health and also submitted a proposal to the Biosciences Research &
Commercialization Center (BRCC) funded by the State of Michigan. We were successful with our first
NIH proposal and the BRCC proposal, allowing us to begin work as a real company. Our
headquarters and Biology Department are located at the Southwest Michigan Innovation Center in
Kalamazoo. Since I had held the position of Research Associate Professor in Chemistry &
Biochemistry at the University of Missouri-St. Louis, we were able to establish and grow the company
under the STTR mechanism, with chemistry done under subcontract to the University. Now, after two
Phase I and two Phase II NIH STTR grants, we have a large set of active compounds with IC50
values in the 8-40 nM range, and many more with IC50s below 100 nM. Furthermore, we have a pair
of compounds in preclinical development and a significant patent estate. The basis of our work is the
design, synthesis and testing of sequence-selective DNA binding molecules that target key
interactions between viral proteins and the viral genome, which is a double-stranded circular DNA
molecule of about 8 kb. Chemistry and biology have been tightly integrated throughout the entire
program, and this has contributed significantly to success. For the purpose of animal studies, we
have scaled up compound synthesis and have tested a wide range of formulations on differentiated
human tissue cultures, organotypic cultures, grown from keratinocyte monolayers.
SCHB 10 50 years of success at Nice Pak Products
Rick West, email@example.com.Nice Pak Products, Orangeburg, NY 10962.
Nice Pak Products / PDI was started a little over 50 years ago by the Julius family and is still
privately owned today. During that time, it has grown from a one room operation in NYC to where it is
today- locations in NY, IN, AR, and a facility currently being built in China. Nice Pak produces
products for the healthcare sector and also for the household sector. Some of the more interesting
product lines will be discussed. Currently, Nice Pak produces approximately three billion wipes a
year. The relative volume of liquid batches produced and some annual chemical consumption data
will be provided. Some of the company's success stories and a few difficulties will be discussed.
SCHB 11 Challenges and opportunities in technology transfer: How are STEM women faring?
Mary Foley Phillips, Mary.Phillips@oregonstate.edu.Office for Commercialization and Corporate
Development Research Office, Oregon State University, Corvallis, OR 97331
As Associate Director for the Office for Commercialization & Corporate Development at Oregon
State University (OSU), Dr. Mary Foley Phillips is responsible for overseeing the management of
intellectual property and licensing of OSU inventions. Dr. Phillips will discuss her perspectives on the
challenges and opportunities in technology transfer for commercializing technology, and will discuss her
views and share insights on how women are faring and can continue to thrive in this environment.
SCHB 12 Challenges of starting (and growing) a start-up
Nicola L. Pohl, firstname.lastname@example.org.Chemistry, Indiana University, Bloomington, IN 47405.
Starting a company is easier than growing it into a success. This talk will focus on the challenges
encountered in founding LuCella Biosciences, Inc., a carbohydrate-focused biotechnology company that
sprung out of university-related research.
SCHB 13 Women-led ventures: Insights from the X Squared Angels Group
Carol Clark, email@example.com X Squared Angels Group, Columbus, OH 43212.
Carol Clark's entrepreneurial roots date back to 1981 when she and Fran Papalios co-founded
MindLeaders, an online software training company that was sold in 2007. Taking what she learned, Carol
became an angel investor and member of several well-known and influential angel groups, including the
Ohio TechAngel Funds, Golden Seeds and Investors' Circle. One of latest endeavors is founding the X
Squared Angels Group - focused on women-led ventures. Carol's background and perspective as both a
female angel investor (who seriously intends to help other women) and as an entrepreneur will help you
gain the insights you need to succeed - whether it is to move your idea ahead or to understand the roles
you, as a women in STEM, can play in technology commercialization. Carol also currently serves on the
College of Arts and Sciences Technology Review Board at the Ohio State University where ideas and
inventions are vetted for commercialization.
SCHB 14 Issues women face in research and commercialization from academia: Personal
insights from a successful company founder
Kathryn Uhrich, firstname.lastname@example.org.Mathematical & Physical Sciences (SAS), Rutgers University,
Piscataway, NJ 08854
As Professor of Chemistry and Dean of Mathematical & Physical Sciences (SAS) at Rutgers
University, Dr. Kathryn Uhrich's research focuses on synthesis and characterization of biocompatible,
biodegradable polymers for medical, dental, cosmetic and personal care applications. In 2000 she co-
founded Polymerix Corporation, a specialty pharmaceutical company developing and commercializing
PolyNSAIDs as coatings for implanted medical devices, such as orthopedic implants, sutures, surgical
meshes, coronary stents, and vascular grafts, as well as long-acting formulations for drug delivery. As a
chemistry professor, dean and company founder, Dr. Uhrich has a unique perspective on the issues
women face in research and commercialization from academia – and she will bring to the discussion her
insights into how women can succeed on all of those fronts.
SCHB 15 Green solvents and ionic liquids: A business venture for the global conservation of
Stanley S Seelig, SSSeelig@aol.com. Seelig and Associates, Lakeland, FL 33810.
Over the last 50 years (or longer) many processes were defined as solvent or water processes (or
solventless or waterless). The halogenated solvents were beneficial as excellent cleaners with recyclable
and reclaimable processes but many had toxicity, ozone depletion or global warming issues. Then many
companies switched back to water based processes only to have to deal with poor cleaning, waste
streams, and excessive surfactants. Now there is an option to switch to green(er) solvents on a global
basis. How can this approach lead to a successful business venture? We will discuss a number of green
solvents and their processes and how they are changing the world away from excessive waste water
streams and assisting to preserve the conservation of water. From laundry to dishwasher to toilets and
more, closed-loop solvent processes are a wave in the future. Water treatment plants are working at
maximum to keep up with technology. Green solvents can relieve some of that pressure. And small
businesses will provide the answers.
SCHB 16 Separation of hydrocarbons from sand or other minerals using ionic liquids
Paul Painter, email@example.com, Bruce Miller, Aron Lupinsky, Maria Sobkowiak, Andrea Choperena,
Nuerxida Pulati.The E&MS Energy Institute, Penn State University, University Park, PA 16802.
The separation or extraction of hydrocarbons such as oil and bitumen from soil, sand, or other
forms of mineral matter is a difficult and expensive process that also results in environmental problems
associated with the disposal of waste products. For example, the separation of bitumen from tar or oil
sands involves large amounts of energy and water. The process water generated in the separation is toxic
to aquatic life and is a major environmental problem. Similarly, the oil and gas industry has to deal with oil
contaminated sand, waste drilling muds and drill cuttings in its operations. We have developed a novel
method for separating bitumen, oil or other hydrocarbons from sand or soils through the use of ionic
liquids (ILs). The separation occurs at ambient temperatures and does not result in the generation of
significant quantities of waste process water. A preliminary patent application and a continuation in part
describing the use of analogue ILs has been filed by the Penn State Research Foundation (PSRF) and a
small company, IL Fuels LLC, founded to develop the technology. The company was granted an exclusive
license to the technology from PSRF in exchange for a 5% equity stake. Some investment funds have
been raised and a small pilot/demonstration unit built at Penn State. Potential licensees are now using the
pilot unit for tests. Conversations with other potential investors and the patent office have been interesting.
The presentation will elaborate on the problems we have faced.
SCHB 17 Production of ionic liquid based electrolytes for electrochemical storage devices
Joe C Poshusta, firstname.lastname@example.org. Boulder Ionics, Arvada, CO 80007.
Ongoing research and development in electrochemical storage devices strives to improve their
capacity, longevity, environmental resilience, and safety. With their wide electrochemical window and low
vapor pressure, electrolytes containing room temperature ionic liquids are a key enabling technology
common to all of these improvements. Electrochemical device applications impose stringent purity
requirements on the electrolyte in order to maintain device lifetime. In particular, halide and water
contamination cannot be tolerated above a few ppm by weight. Conventional ionic liquid synthesis often
involves solvent based reactions, halide intermediates, and repetitive batch-wise purification to achieve
electrochemical device requirements. While able to synthesize a wide variety of ionic liquids, these labor
intensive and time consuming methods drive up cost, leading many device manufacturers to reject ionic
liquids. Boulder Ionics has developed alternative synthetic routes adapted to scalable continuous
processing techniques that can provide electrochemical grade ionic liquids in system residence times of
just minutes. While vastly reducing labor cost, the continuous approach also enables tight process control
and minimizes product handling, producing a high purity material. Ionic liquids and salts of interest for
electrochemical devices include the fluorinated anioIns bis(trifluoromethyl sulfonyl)imide (TFSI) and
bis(fluorosulfonyl)imide (FSI). These anions are often paired with pyrolidinium and imidazolium based
cations in ionic liquids, while their lithium salts are useful in lithium and lithium-ion batteries. The TFSI
anion has been commercially available for several years, but its cost can dominate the ionic liquid material
cost. We have developed a scalable synthetic route to the much less expensive FSI anion, while at the
same time proving to meet performance requirements as demonstrated by our development partners and
other researchers. This presentation will review some of the performance capabilities of FSI based ionic
liquids in electrochemical storage devices as well as discuss synthetic approaches to manufacturing
related electrolyte systems.
SCHB 18 Using academic resources to expand your chemical enterprise: Graphenics, LLC
Rachel M Frazier1,2, email@example.com, Hunter Adams2, Dan T Daly1. (1) Alabama Innovation and
Mentoring of Entrepreneurs, The University of Alabama, Tuscaloosa, AL 35487, (2) Graphenics, LLC,
Tuscaloosa, AL 35487.
Ionic liquids (ILs) have numerous applications, making them ideal materials for platform
technologies. A key challenge to any new material is advancing from the laboratory to the marketplace,
thereby bridging the gap from proof-of-concept to prototype. ILs are no exception to this process, thus we
explore the developmental part Alabama Innovation and Mentoring of Entrepreneurs (AIME) plays in
transitioning ILs from invention to innovation. We will explore the vital role AIME has played in helping to
set up Graphenics, LLC for success. Exfoliation of graphite in ILs to produce graphene has been identified
as having significant potential for success and AIME has assisted in developing the technology beyond
proof-of-concept. We will present the translation of this technology from academia to the marketplace and
a case study of a new chemical enterprise, Graphenics. Graphenics, LLC provides graphene materials
and consulting services to both academia and industry. Graphenics core strength is the expertise in the
exfoliation of graphite and the know-how of the proprietary process technology.
SCHB 19 Novel chitin fibers for wound care
Robin D Rogers, firstname.lastname@example.org, Gabrielle Gurau.AIME, University of Alabama, Tuscaloosa, AL
525 Solutions, Inc., a faculty start-up incubated at The University of Alabama with a mission to
transfer fundamental research into new business enterprises while providing opportunities for students
and staff to become entrepreneurs, proposes to use the newly discovered property of ionic liquids (ILs;
salts which melt below 100 oC) to dissolve high molecular weight chitin directly from biomass to design
novel composite fibers of natural polymers with embedded additives to improve the immune system and
facilitate wound healing. 525 Solutions, Inc., will use the proprietary process to directly dissolve
biopolymers (e.g., chitin, alginate, etc.) with or without functional additives into homogeneous solutions
which will allow for the direct dry-jet wet spinning of composite materials.
SCHB 20 CO2 recycling using microalgae for the production of liquid fuels
M. M Crocker1, email@example.com, M.H.W. Wilson1, J. Groppo1, A. Placido1, S. Graham1,
A. Santillan-Jiminez1, T. Morgan1, J. Shoup1, D. Kim1, L. Mills1, H. Y Shin1, C. Crofcheck2. (1) Center for
Applied Energy Research, University of Kentucky, Lexington, KY 40511, (2) Department of Biosystems &
Agricultural Engineering, University of Kentucky, Lexington, KY 40511.
Given the potential of microalgae for recycling CO2 into bio-products, coupled with the large
number of coal-fired power plants in Kentucky, the Commonwealth of Kentucky's Department of Energy
Development and Independence tasked the University of Kentucky with determining the technical and
economic feasibility of algae-based carbon capture and utilization in Kentucky. These research efforts
have led to the development and on-going deployment of a pilot-scale photobioreactor system at Duke
Energy's East Bend station. This pilot-scale project is focused on process development/improvement,
power plant integration, and the implementation of strategies to increase algae growth rates. The system
is continuously monitored and the process data analyzed to gain insights into system dynamics and to
improve the operation/design of future units. In tandem, we have developed a protocol for the harvesting
and dewatering of algae (with minimal energy input) based on flocculation-sedimentation. Methodologies
have also been developed for lipid extraction (from dry and wet algal biomass) and for the conversion of
extracted lipids to liquid hydrocarbons by means of catalytic deoxygenation.
SCHB 21 Microflotation for microorganism harvest
James O. Hanotu, firstname.lastname@example.org, William B.J. Zimmerman.Perlemax Ltd., Sheffield, United
Microbial cells or microorganisms are grown in bioreactors under conditions where they thrive and
flourish, yielding a wide range of desired end products. Yeast, Bacteria and Algae are some of the most
widely explored microorganisms and have been applied for food, water remediation and biofuel
production. After the appropriate number of generations, the mature cell mass is separated from the spent
liquid, then delivered as liquid cream, filtered, and sold as compressed forms or filtered and dried into
instant dry cells. On occasions when a heterogeneous community is cultured, selective harvesting can
possibly be employed to recover only the desired organism(s). The conventional approach to extracting
cells from their growth medium is by centrifugation and filtration. However, these methods are expensive
and often unsuitable for continuous large-scale production. Conversely, traditional flotation separation
techniques (such as Dissolved Air Flotation) are regarded as both intrusive and energy intensive, and are
only naturally suitable for portable water treatment. Our microflotation technique is advantageous due to
its laminar flow process, its non-intrusiveness, and scalability to meet continuous industrial production
requirements. The efficacy of microflotation has been demonstrated for algal biomass recovery, as well as
for yeast, showing optimum recovery rates comparable to ideal flotation separation results.
SCHB 22 Integrated energy parks as a model for rural economic development and energy
diversification in the Appalachian coalfields
Roger Ford1, email@example.com, Eric Mathis2. (1) Patriot Bioenergy Corporation, Pikeville,
KY 41501, (2) Emergy Holdings, Inc., Williamson, WV 25661.
Patriot Bioenergy Corporation and Emergy Holdings, Inc. have developed a business model that
provides diversified energy production on post-mining land in the Appalachian coalfields termed Integrated
Energy Parks. Through integration of energy resources, the business model couples solar, natural gas,
and biomass to generate electricity and to produce energy-related products on post-mining land. As a
start-up, we discuss the challenges associated with regulatory barriers and construction of such facilities,
as well as the discussion of the dynamics that move us toward energy diversification and integration in the
heart of the Appalachian coalfields. Issues discussed include production of sufficient biomass feedstock,
post-mining land use, market-based sustainability strategies, and adoption of an 'all-of-the-above' energy
- NOTES -