Anatomy & Physiology 2
Summer 2004
Chapter 22 – Lymphatics and Immunity

Copyright © 2004 Pearson Education, Inc., publish...
Figure 22.1 The Components of the Lymphatic
System

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummi...
Figure 22.2 Lymphatic Capillaries

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Figure 22.2a...
Figure 22.3 Lymphatic Vessels and Valves

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Figur...
Figure 22.4 The Relationship between the
Lymphatic Ducts and the Venous System

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Figure 22.4 The Relationship between the
Lymphatic Ducts and the Venous System

Copyright © 2004 Pearson Education, Inc., ...
Figure 22.6 Lymphoid Nodules

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Figure 22.6
Figure 22.7 The Structure of a Lymph Node

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Figu...
Figure 22.5 The Derivation and Distribution of
Lymphocytes

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Lymphatic system and body defenses

• Nonspecific defenses –

• Specific defenses-

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Figure 22.10 Nonspecific Defenses
(Part 1 - Physical Barriers)

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Nonspecific Defenses, Phagocytes

• Remove cellular debris and respond to invasion
by foreign pathogens
• Monocyte-macroph...
Figure 22.10 Nonspecific Defenses
(Part 2 - Phagocytes)

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Figure 22.10 Nonspecific Defenses
(Part 3 - Immunological Surveillance)

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Nonspecific Defenses, Interferons (cytokines)
• Small proteins released by virally infected cells
• Trigger the production...
Figure 22.10 Nonspecific Defenses
(Part 5 - Complement System)

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Figure 22.13 Inflammation

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Figure 22.13
Figure 22.10 Nonspecific Defenses
(Part 7 - Fever)

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Figure 22.14 Types of Immunity

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Figure 22.14
Properties of immunity

• Specificity – activated by and responds to a
specific antigen
• Versatility – is ready to confro...
The immune system response

• Antigen triggers an immune response
• Activates T cells and B cells
• T cells are activated ...
Figure 22.15 An Overview of the Immune
Response

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Major types of T cells

• Cytotoxic T cells (TC) – attack foreign cells
• Helper T cells (TH) – activate other T cells and...
Figure 22.16 Antigens and MHC Proteins

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Figure ...
Figure 22.16 Antigens and MHC Proteins

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Figure ...
Figure 22.17 Antigen Recognition and the
Activation of Cytotoxic T Cells

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Figure 22.17 Antigen Recognition and the
Activation of Cytotoxic T Cells

PLAY

Animation: Cytotoxic T Cell Activation

Co...
Figure 22.18 Antigen Recognition and
Activation of Helper T cells

PLAY

Animation: Antigen Recognition and Helper T Cell ...
Figure 22.19 A Summary of the Pathways of T
Cell Activation

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Figure 22.20 The Sensitization and Activation of
B Cells

PLAY

Animation: B Cells and Antibody Production

Copyright © 20...
Figure 22.21 Antibody Structure

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Figure 22.21
Figure 22.21 Antibody Structure

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Figure 22.21a
Figure 22.21 Antibody Structure

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Figure 22.21b-...
Actions of antibodies include:

• Neutralization
• Agglutination and precipitation
• Activation of complement
• Attraction...
Figure 22.22 The Primary and Secondary
Immune Responses

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin ...
Figure 22.23 An Integrated Summary of the
Immune Response

Copyright © 2004 Pearson Education, Inc., publishing as Benjami...
Figure 22.25 The Course of the Body’s Response
to Bacterial Infection

Copyright © 2004 Pearson Education, Inc., publishin...
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AS lymphaticsimmunity colstons notes

  1. 1. Anatomy & Physiology 2 Summer 2004 Chapter 22 – Lymphatics and Immunity Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
  2. 2. Figure 22.1 The Components of the Lymphatic System Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.1
  3. 3. Figure 22.2 Lymphatic Capillaries Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.2a, b
  4. 4. Figure 22.3 Lymphatic Vessels and Valves Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.3a, b
  5. 5. Figure 22.4 The Relationship between the Lymphatic Ducts and the Venous System Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.4a
  6. 6. Figure 22.4 The Relationship between the Lymphatic Ducts and the Venous System Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.4b
  7. 7. Figure 22.6 Lymphoid Nodules Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.6
  8. 8. Figure 22.7 The Structure of a Lymph Node Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.7
  9. 9. Figure 22.5 The Derivation and Distribution of Lymphocytes Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.5a-c
  10. 10. Lymphatic system and body defenses • Nonspecific defenses – • Specific defenses- Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
  11. 11. Figure 22.10 Nonspecific Defenses (Part 1 - Physical Barriers) Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.10
  12. 12. Nonspecific Defenses, Phagocytes • Remove cellular debris and respond to invasion by foreign pathogens • Monocyte-macrophage system - Fixed and free • Microphages – Neutrophils and eosinophils • Move by diapedesis • Exhibit chemotaxis Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
  13. 13. Figure 22.10 Nonspecific Defenses (Part 2 - Phagocytes) Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.10
  14. 14. Figure 22.10 Nonspecific Defenses (Part 3 - Immunological Surveillance) Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.10
  15. 15. Nonspecific Defenses, Interferons (cytokines) • Small proteins released by virally infected cells • Trigger the production of antiviral proteins • Three major types of interferons are: • Alpha– produced by leukocytes and attract/stimulate NK cells • Beta– secreted by fibroblasts causing slow inflammation • Gamma – secreted by T cells and NK cells stimulate macrophage activity Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
  16. 16. Figure 22.10 Nonspecific Defenses (Part 5 - Complement System) Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.10
  17. 17. Figure 22.13 Inflammation Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.13
  18. 18. Figure 22.10 Nonspecific Defenses (Part 7 - Fever) Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.10
  19. 19. Figure 22.14 Types of Immunity Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.14
  20. 20. Properties of immunity • Specificity – activated by and responds to a specific antigen • Versatility – is ready to confront any antigen at any time • Memory – “remembers” any antigen it has encountered • Tolerance – responds to foreign substances but ignores normal tissues Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
  21. 21. The immune system response • Antigen triggers an immune response • Activates T cells and B cells • T cells are activated after phagocytes exposed to antigen • T cells attack the antigen and stimulate B cells • Activated B cells mature and produce antibody • Antibody attacks antigen Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
  22. 22. Figure 22.15 An Overview of the Immune Response Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.15
  23. 23. Major types of T cells • Cytotoxic T cells (TC) – attack foreign cells • Helper T cells (TH) – activate other T cells and B cells • Suppressor T cells (TS) – inhibit the activation of T and B cells Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
  24. 24. Figure 22.16 Antigens and MHC Proteins Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.16
  25. 25. Figure 22.16 Antigens and MHC Proteins Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.16b
  26. 26. Figure 22.17 Antigen Recognition and the Activation of Cytotoxic T Cells Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.17
  27. 27. Figure 22.17 Antigen Recognition and the Activation of Cytotoxic T Cells PLAY Animation: Cytotoxic T Cell Activation Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.17
  28. 28. Figure 22.18 Antigen Recognition and Activation of Helper T cells PLAY Animation: Antigen Recognition and Helper T Cell Activation Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.18
  29. 29. Figure 22.19 A Summary of the Pathways of T Cell Activation Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.19
  30. 30. Figure 22.20 The Sensitization and Activation of B Cells PLAY Animation: B Cells and Antibody Production Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.20
  31. 31. Figure 22.21 Antibody Structure Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.21
  32. 32. Figure 22.21 Antibody Structure Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.21a
  33. 33. Figure 22.21 Antibody Structure Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.21b-d
  34. 34. Actions of antibodies include: • Neutralization • Agglutination and precipitation • Activation of complement • Attraction of phagocytes • Opsinization • Stimulation of inflammation • Prevention of adhesion Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
  35. 35. Figure 22.22 The Primary and Secondary Immune Responses Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.22
  36. 36. Figure 22.23 An Integrated Summary of the Immune Response Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.23
  37. 37. Figure 22.25 The Course of the Body’s Response to Bacterial Infection Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.25a, b

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