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Selective inhibition of Leishmania donovani by active extracts of
wild mushrooms used by the tribal population of India: A...
INTRODUCTION
LEISHMANIASIS
L. DONOVANI
.
MUSHROOMS
EXTRACT
Is a maceration type, in which the
liquid solvent is a mixture of ethyl
alcohol and water, which dissolved
the ac...
Lab
tests
Lab
tests
GENERAL OBJECTIVE
MATERIALES Y METODOS
Preparación de
extractos
MATERIALES Y METODOS
MATERIALES Y METODOS
MATERIALES Y METODOS
 Reacción antígeno-anticuerpo basada en la identificación del
receptor de membrana por medio de fluorocromo.

Para evalu...
MATERIALES Y METODOS
MATERIALES Y METODOS
ACTIVIDAD ANTI-PROMASTIGOTE
ACTIVIDAD ANTI-PROMASTIGOTE
ACUMULACIÓN DE LÍPIDOS EN
PROMASTIGOTES
ACUMULACIÓN DE LÍPIDOS EN
PROMASTIGOTES
APOPTOSIS EN
PROMASTIGOTES
CONDENSACIÓN DE LA
CROMATINA Y
FRAGMENTACIÓN
NUCLEAR
TOXICIDAD DE LOS
EXTRACTOS ACTIVOS DE
LOS HONGOS
LIBERACION DE IL-12
Author What the author said Yes/No
Ghosh et al IL-12 interacts with NK cells
and induces IFN-g specific Th1
cells differen...
Author What the author said Yes/No
Owens In experimental visceral leishmaniasis, splenic
conventional DCs are the first ce...
It´s important to not underestimate the beliefs or rituals of
tribes because as we saw in this study, it is in the beliefs...
As science has evolved, the importance of the relationship
and integration between medicine, technology and natural
resour...
Ana María Parada P
Sofía
Medina
Seminario biologia molecular  l. donovani
Seminario biologia molecular  l. donovani
Seminario biologia molecular  l. donovani
Seminario biologia molecular  l. donovani
Seminario biologia molecular  l. donovani
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Seminario biologia molecular l. donovani

  1. 1. Selective inhibition of Leishmania donovani by active extracts of wild mushrooms used by the tribal population of India: An in vitro exploration for new leads against parasitic protozoans Suvadip Mallick, Aritri Dutta, Somaditya Dey, Joydip Ghosh, Debarati Mukherjee, Sirin Salma Sultana, Supratim Mandal, Soumitra Paloi, Somanjana Khatua, Krishnendu Acharya, Chiranjib Pal. Sofía Medina Ana María Parada III Semestre
  2. 2. INTRODUCTION
  3. 3. LEISHMANIASIS
  4. 4. L. DONOVANI .
  5. 5. MUSHROOMS
  6. 6. EXTRACT Is a maceration type, in which the liquid solvent is a mixture of ethyl alcohol and water, which dissolved the active substances contained in the raw material. In other words, it is "the power of a raw material" to become a "drug”.
  7. 7. Lab tests Lab tests
  8. 8. GENERAL OBJECTIVE
  9. 9. MATERIALES Y METODOS Preparación de extractos
  10. 10. MATERIALES Y METODOS
  11. 11. MATERIALES Y METODOS
  12. 12. MATERIALES Y METODOS
  13. 13.  Reacción antígeno-anticuerpo basada en la identificación del receptor de membrana por medio de fluorocromo.  Para evaluar apoptosis y variabilidad  Diferentes marcadores MATERIALES Y METODOS
  14. 14. MATERIALES Y METODOS
  15. 15. MATERIALES Y METODOS
  16. 16. ACTIVIDAD ANTI-PROMASTIGOTE
  17. 17. ACTIVIDAD ANTI-PROMASTIGOTE
  18. 18. ACUMULACIÓN DE LÍPIDOS EN PROMASTIGOTES
  19. 19. ACUMULACIÓN DE LÍPIDOS EN PROMASTIGOTES
  20. 20. APOPTOSIS EN PROMASTIGOTES
  21. 21. CONDENSACIÓN DE LA CROMATINA Y FRAGMENTACIÓN NUCLEAR
  22. 22. TOXICIDAD DE LOS EXTRACTOS ACTIVOS DE LOS HONGOS
  23. 23. LIBERACION DE IL-12
  24. 24. Author What the author said Yes/No Ghosh et al IL-12 interacts with NK cells and induces IFN-g specific Th1 cells differentiation, required for disease demolition Yes Lai et al To emphasize the findings, a novel astrakurkurone molecule with excellent antileihmanial activity against L. donovani promastigotes has alredy been insolated from A. hygrometricus by our group Yes
  25. 25. Author What the author said Yes/No Owens In experimental visceral leishmaniasis, splenic conventional DCs are the first cells to produce IL-12 within the splenic microenviroment, and are activated for heightened expression of a variety of costimulatory molecules through both direct interactions with Leishmania parasites and through inflammatory signals No mentioned Liew et al Release of nitric oxide is associated with pro- inflammatory cytokine TNF-a, wich has been also reportedto enhance the killing of intracellular amastigotes Yes
  26. 26. It´s important to not underestimate the beliefs or rituals of tribes because as we saw in this study, it is in the beliefs and rituals that we can start to develop new cures to diseases whos current treatment is not accesible to everyone This study proved the influence of mushrooms extract on the metabolism of lipids and the induction of apoptosis. This can help us in finding or producing new drugs with similar mechanism in order to efectively attack the parasite.
  27. 27. As science has evolved, the importance of the relationship and integration between medicine, technology and natural resources has become more evident. It´s risky to affirm that the addition of mushroom extracts does not produce negative effects on the organism because the difference in the percentage of control and treated cellular death is not significant.
  28. 28. Ana María Parada P
  29. 29. Sofía Medina
  • ChiranjibPal

    Jul. 28, 2020
  • GopiRajendra1

    Oct. 24, 2018

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