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DiabetesMine University 2019: Beta Bionics iLet Preview

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* Part of the first-ever DIABETESMINE CLOSED LOOP SYSTEM SHOWCASE *

Ed Raskin of Beta Bionics gave a detailed preview of the iLet closed loop automated insulin delivery system at the Fall 2019 DiabetesMine D-Data ExChange.

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DiabetesMine University 2019: Beta Bionics iLet Preview

  1. 1. Con DiabetesMine AID Showcase 2019 iLet – the world’s first bionic pancreas
  2. 2. we are here …
  3. 3. Source: Miller et al., Diabetes Care (2015) 38:971–978 2–5 (N = 236) 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 6–12 (N = 3,313) 13–17 (N = 4,914) 18–25 (N = 2,867) 26–49 (N = 2,606) ≥ 50 (N = 2,125) Age Group (Years) 24% 24% 20% 19% 30% 29% % of people meeting – and not meeting – A1c target A1c target < 7.5 A1c target < 7.0
  4. 4. Source: Miller et al., Diabetes Care (2015) 38:971–978 2–5 (N = 236) 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 6–12 (N = 3,313) 13–17 (N = 4,914) 18–25 (N = 2,867) 26–49 (N = 2,606) ≥ 50 (N = 2,125) Age Group (Years) 24% 24% 20% 19% 30% 29% % of people meeting – and not meeting – A1c target A1c target < 7.5 A1c target < 7.0 From 2016-2018 things generally got worse
  5. 5. | Beta Bionics4 The iLet(TM) Bionic Pancreas System Caution: The iLet is an investigational device, limited by federal law to investigational use Glucagon Cartridge Insulin Cartridge
  6. 6. | Beta Bionics5 The iLet Bionic Pancreas System Caution: The iLet is an investigational device, limited by federal law to investigational use iLet thinks for you •Simple to start - enter weight and go • No basal rates • No correction ratio •Easy to maintain • Prefilled glucagon • Prefilled insulin options •Easy to use - no carb counting • Easy and optional meal announcement • No insulin to carb ratios •Learns about your insulin needs and grows with you in perpetuity
  7. 7. Insulin-only Bionic Pancreas & iLet Results - Adults ADA Goal for Therapy A1C: 7.0% (154 mg/dL) 20-30% achieve goal
  8. 8. ADA Goal for Therapy A1C: 7.0% (154 mg/dL) 20-30% achieve goal Insulin-only Bionic Pancreas & iLet Results - Adults
  9. 9. Sources: Russell et al., N. Engl. J. Med. (2014) 371:313–325; Russell et al., Lancet Diabetes Endocrinol. (2016) 4:233–243; El-Khatib et al., Lancet (2016) 389:369–380 ADA Goal for Therapy A1C: 7.0% (154 mg/dL) Insulin-only Bionic Pancreas (pre-iLet studies) Mean CGM: 154mg/dL Time <60mg/dL: 1.2% Time >180mg/dL: 27% Time 60-180mg/dL: 71.8% 20-30% achieve goal About 1/2 expected to achieve goal Insulin-only Bionic Pancreas & iLet Results - Adults
  10. 10. Sources: Russell et al., N. Engl. J. Med. (2014) 371:313–325; Russell et al., Lancet Diabetes Endocrinol. (2016) 4:233–243; El-Khatib et al., Lancet (2016) 389:369–380 ADA Goal for Therapy A1C: 7.0% (154 mg/dL) Insulin-only Bionic Pancreas (pre-iLet studies) Mean CGM: 154mg/dL Time <60mg/dL: 1.2% Time >180mg/dL: 27% Time 60-180mg/dL: 71.8% the iLet™ Carry your glucose metabolism in your pocket. 20-30% achieve goal About 1/2 expected to achieve goal Insulin-only Bionic Pancreas & iLet Results - Adults
  11. 11. ADA Goal for Therapy A1C: 7.0% (154 mg/dL) Insulin-only Bionic Pancreas (pre-iLet studies) Mean CGM: 154mg/dL Time <60mg/dL: 1.2% Time >180mg/dL: 27% Time 60-180mg/dL: 71.8% Insulin-only iLet (protype) Mean CGM: 155mg/dL Time <60mg/dL: 1.2% Time >180mg/dL: 27% Time 60-180mg/dL: 71.8% 20-30% achieve goal About 1/2 expected to achieve goal About 1/2 expected to achieve goal Insulin-only Bionic Pancreas & iLet Results - Adults
  12. 12. Bihormonal Bionic Pancreas & iLet Results - Adults ADA Goal for Therapy A1C: 7.0% (154 mg/dL) 20-30% achieve goal
  13. 13. Sources: Russell et al., N. Engl. J. Med. (2014) 371:313–325; Russell et al., Lancet Diabetes Endocrinol. (2016) 4:233–243; El-Khatib et al., Lancet (2016) 389:369–380 ADA Goal for Therapy A1C: 7.0% (154 mg/dL) Bihormonal Bionic Pancreas (pre-iLet studies w/rescue glucagon) Mean CGM: 140mg/dL Time <60mg/dL: .9% Time >180mg/dL: 19% Time 60-180mg/dL: 80.1% 20-30% achieve goal About 90% expected to achieve goal Bihormonal Bionic Pancreas & iLet Results - Adults
  14. 14. ADA Goal for Therapy A1C: 7.0% (154 mg/dL) Bihormonal Bionic Pancreas (pre-iLet studies w/rescue glucagon) Mean CGM: 140mg/dL Time <60mg/dL: .9% Time >180mg/dL: 19% Time 60-180mg/dL: 80.1% 20-30% achieve goal About 90% expected to achieve goal Bihormonal Bionic Pancreas & iLet Results - Adults Bihormonal Bionic Pancreas (iLet study w/prefilled dasiglucagon [Zealand]) Mean CGM: 139mg/dL Time <54mg/dL: .3% Time >180mg/dL: 18.6% Time 70-180mg/dL: 79% About 90% expected to achieve goal
  15. 15. How to start a bionic pancreas: The iLet set-up process
  16. 16. Initializing the iLet Caution: The iLet is an investigational device, limited by federal law to investigational use
  17. 17. Initializing the iLet Caution: The iLet is an investigational device, limited by federal law to investigational use
  18. 18. Initializing the iLet Caution: The iLet is an investigational device, limited by federal law to investigational use
  19. 19. Initializing the iLet Caution: The iLet is an investigational device, limited by federal law to investigational use
  20. 20. Initializing the iLet Caution: The iLet is an investigational device, limited by federal law to investigational use
  21. 21. Initializing the iLet Caution: The iLet is an investigational device, limited by federal law to investigational use
  22. 22. Initializing the iLet Caution: The iLet is an investigational device, limited by federal law to investigational use
  23. 23. Initializing the iLet Caution: The iLet is an investigational device, limited by federal law to investigational use
  24. 24. Initializing the iLet Caution: The iLet is an investigational device, limited by federal law to investigational use
  25. 25. How to give an optional meal announcement Caution: The iLet is an investigational device, limited by federal law to investigational use
  26. 26. Meal Announcement ( “usual” size ) Caution: The iLet is an investigational device, limited by federal law to investigational use
  27. 27. Meal Announcement ( “usual” size ) Caution: The iLet is an investigational device, limited by federal law to investigational use
  28. 28. Meal Announcement ( “usual” size ) Caution: The iLet is an investigational device, limited by federal law to investigational use
  29. 29. Meal Announcement ( “usual” size ) Caution: The iLet is an investigational device, limited by federal law to investigational use
  30. 30. Meal Announcement ( “usual” size ) Caution: The iLet is an investigational device, limited by federal law to investigational use
  31. 31. Meal Announcement ( “usual” size ) Caution: The iLet is an investigational device, limited by federal law to investigational use
  32. 32. | Beta Bionics31 Series A/A2 Round of Financing $10m raised in 2016
  33. 33. | Beta Bionics32 Series B/B2 Financing Rounds $126m raised in 2018/2019

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