Diabetes Mellitus Type 2 And Free Fatty Acids

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The role of fatty acids in the pathogenesis of Type II Diabetes Mellitus

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  • Diabetes Mellitus Type 2 And Free Fatty Acids

    1. 1. Fatty Acids and the development of Type 2 Diabetes Mellitus Amit Sud
    2. 2. Type 2 Diabetes Mellitus <ul><li>Clinical Diagnosis 1 : </li></ul><ul><ul><li>Fasting Plasma Glucose ≥7.0mmol/L </li></ul></ul><ul><ul><li>Random Plasma Glucose ≥ 11.1mmol/L </li></ul></ul><ul><ul><li>OGTT: 2 hours following dose ≥ 11.1mmol/L </li></ul></ul><ul><li>~2.1 million people in England with Type 2 Diabetes Mellitus 2 </li></ul>
    3. 3. Obesity and insulin resistance <ul><li>Increase in BMI associated with an increase in the prevalence and incidence of Type II Diabetes 3, 4 </li></ul><ul><li>High Free Fatty Acid levels increase the risk of Type 2 Diabetes 5,6 </li></ul><ul><li>Visceral Adiposity correlates with Insulin resistance 7 </li></ul>
    4. 4. Potential mechanisms of insulin resistance in muscle cells The importance of fatty acids in the development of type 2 diabetes. Wilding JPH. Diabetic Medicine . 2007. 24 p. 934-945
    5. 5. Fatty Acid Signalling and insulin secretion in the β -cell Fatty Acid Signalling in the β -cell and insulin secretion. Nolan CJ, Madiraju M, Delghingaro-Augusto V, Peyot M, Prentki. Diabetes . 2006. 55 (S2) p.S16-S23
    6. 6. Summary ↑ Fat Storage (especially visceral adipose tissue) ↑ FFA ↑ Adipokines ↑ FFA ↑ Adipokines ↓ Adiponectin β cell failure Insulin Resistance Impaired Glucose Tolerance Diabetes Positive Energy Balance Modified from: The importance of fatty acids in the development of type 2 diabetes. Wilding JPH. Diabetic Medicine . 2007. 24 p. 934-945 Genetic Predisposition
    7. 7. <ul><li>Thank you for your time </li></ul><ul><li>Any questions? </li></ul>
    8. 8. References <ul><li>1. World Health Organization. Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycaemia. 2006. </li></ul><ul><li>2. Roberts S, Working together for better Diabetes Care 2007. Department of Health. </li></ul><ul><li>3. Bays HE, Chapman RH, Grandy S. The relationship of Body Mass Index to Diabetes Mellitus, Hypertension and Dyslipidaemia: Comparison of data from two national surveys. International Journal of Clinical Practice 2007; 61 (5): p. 737-747 </li></ul><ul><li>4. Wannamethee SG, Shaper AG. Weight change and duration of overweight and obesity in the incidence of type 2 diabetes. Diabetes Care 1999; 22 : p. 1266– 1272. </li></ul><ul><li>5. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997; 46 (1): p. 3-10 </li></ul><ul><li>6. Pankow JS, Duncan BB, Schmidt MI, et al . Fasting plasma free fatty acids and risk of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes Care 2004; 27 : p. 77–82. </li></ul><ul><li>7. Raz I, Eldor R, Cernea S, Shafrir E. Diabetes: insulin resistance and derangements in lipid metabolism. Cure through intervention in fat transport and storage. Diabetes/Metabolism Research Reviews 2004; 21 (1): p. 3-14 </li></ul>

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