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In early 2014 we upgraded JASPAR, the largest open-access, manually curated, database storing transcription factor (TF) binding profiles (PMID:24194598), and are in the process of preparing the 2016 release. A new BioPython module dedicated to accessing and using TF binding profiles stored in JASPAR is available, which we will introduce in the first portion of the webinar.
In the second part of the webinar, we will introduce the MANTA (Mongodb for the ANalysis of Tfbs Alteration) database we used for the analysis of cis-regulatory somatic mutations in B-cell lymphomas (PMID:25903198). The database stores positions of predicted TFBSs in ChIP-seq data using JASPAR TF binding profiles. We will describe the database and how to access and use it.