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Disseminated intravascular coagulation (dic)


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Disseminated intravascular coagulation (dic)

  2. 2. DIC<br />It is an acute, subacute, or chronic thrombohemorrrhagicdisorder.<br />It occurs as secondary complication of various diseases.<br />An acquired syndrome characterized by systemicintravascularcoagulation<br />Coagulation is always the initial event.<br />WWW.<br />
  3. 3. DIC<br />SYSTEMIC ACTIVATION OF COAGULATION<br />Most morbidity and mortality depends on extent of intravascular thrombosis<br />Intravascular deposition of fibrin<br />Depletion of platelets and coagulation factors<br />Thrombosis of small and midsize vessels<br />Bleeding<br />DEATH<br />Organ failure<br />
  4. 4. D. I. C. Causes<br />
  5. 5. Clinical Manifestations of DIC<br />Ischemic Findings<br />are earliest!<br />Bleeding is the most <br />obvious <br />clinical finding<br />
  6. 6. Clinical Manifestations of DIC<br />
  7. 7. Laboratory diagnosis<br />Thrombocytopenia<br />platelet count <100,000 or rapidly declining<br />Prolonged clotting times (PT, APTT)<br />Presence of Fibrin degradation products or positive D-dimer<br />Low levels of coagulation inhibitors<br />AT III, protein C<br />Low levels of coagulation factors<br />Factors V,VIII,X,XIII<br />Fibrinogen levels not useful diagnostically<br />
  8. 8. Treatment of DIC<br />Stop the triggering process .<br />The only proven treatment!<br />Supportive therapy<br />No specific treatments<br />Plasma and platelet substitution therapy<br />Anticoagulants<br />Physiologic coagulation inhibitors<br />
  9. 9. Summary<br />DIC is a syndrome characterized systemic intravascular coagulation.<br />Coagulation is the initial event and the extent of intravascular thrombosis has the greatest impact on morbidity and mortality.<br />Important link between inflammation and coagulation. <br />Morbidity and mortality remain high.<br />The only proven treatment is reversal or controlof the underlying cause.<br />
  10. 10. n<br />CHAUHAN<br />