Allera Health P roducts
                 Developer of patented, all natural, P roligna® pine
                 cone extract...
How to increase your
         immunity to stay
         healthy!
                 Frank Tufaro, Ph.D.
                 CEO...
Infections of major concern 75 years ago....
   are somewhat different today... (N. America)
                             ...
ALLERA HEALTH, INC.


Wednesday, May 19, 2010
Proof that our immune system is
          extremely powerful:




                                    ALLERA HEALTH, INC.
...
Proof that our immune system is
          extremely powerful:
          Vaccines have eliminated or greatly
          redu...
Proof that our immune system is
          extremely powerful:
          Vaccines have eliminated or greatly
          redu...
Proof that our immune system is
          extremely powerful:
          Vaccines have eliminated or greatly
          redu...
Unfortunately, new threats
                          emerge to challenge your
                          healthy immune sys...
What are the requirements for an
     effective immune system?
                          •Specific
                        ...
ALLERA HEALTH, INC.


Wednesday, May 19, 2010
Portals of entry...




                              ALLERA HEALTH, INC.


Wednesday, May 19, 2010
Portals of entry...
        Nose              breathing in cold and flu, allergens


        Mouth             eating food,...
Portals of entry...
        Nose              breathing in cold and flu, allergens


        Mouth             eating food,...
Portals of entry...
        Nose              breathing in cold and flu, allergens


        Mouth             eating food,...
Portals of entry...
        Nose              breathing in cold and flu, allergens


        Mouth             eating food,...
Best remedy: avoid infection!
                          Your first line of defense:




                                   ...
Best remedy: avoid infection!
                          Your first line of defense:
                               •Mucus

...
Best remedy: avoid infection!
                          Your first line of defense:
                               •Mucus
 ...
Best remedy: avoid infection!
                          Your first line of defense:
                               •Mucus
 ...
Best remedy: avoid infection!
                          Your first line of defense:
                               •Mucus
 ...
Best remedy: avoid infection!
                          Your first line of defense:
                               •Mucus
 ...
Best remedy: avoid infection!
                          Your first line of defense:
                               •Mucus
 ...
Your immune system also recognizes
     foreign molecules that arise from within...
          •Cancer cells express “forei...
Your immune system is a
           food critic?
           •70% of your immune system is in your digestive
           trac...
Do you recognize these diseases
     affected by the immune system?
                          •arthritis
                 ...
Diseases increase as we age and
                our immune system weakens
                          Arthritis        Diabe...
What impacts immunity
       •Diseases
       •Pharmaceutical drugs (e.g. chemotherapy)
       •Genetics
       •Age
     ...
Your Immune System




                                   ALLERA HEALTH, INC.


Wednesday, May 19, 2010
Your Immune System
      2 types of immunity:




                                   ALLERA HEALTH, INC.


Wednesday, May ...
Your Immune System
      2 types of immunity:
      Innate Immunity (hard wired)




                                     ...
Your Immune System
      2 types of immunity:
      Innate Immunity (hard wired)
      Acquired Immunity (adaptable)




 ...
Your Immune System
      2 types of immunity:
      Innate Immunity (hard wired)
      Acquired Immunity (adaptable)




 ...
Your Immune System
      2 types of immunity:
      Innate Immunity (hard wired)
      Acquired Immunity (adaptable)


   ...
Your Immune System
      2 types of immunity:
      Innate Immunity (hard wired)
      Acquired Immunity (adaptable)


   ...
Your Immune System
      2 types of immunity:
      Innate Immunity (hard wired)
      Acquired Immunity (adaptable)


   ...
Immune cells have specialized roles to play




              Innate immunity          Adaptive immunity
             (Rap...
Innate immunity is inherited
   Your innate immune system
   can recognize danger signals
   through the use of specialize...
Dendritic cells tell your immune system what to look for

       Dendritic cells play an important part               Dend...
Adaptive Immunity
                  Acquired immunity employs many weapons
                                       infected...
T-helper cells play a key role...

         •Stimulate other immune cells to function properly
         •Possess very powe...
T helper cells (continued)
           Th1- participate in cell-mediated immunity
           help control viruses and bacte...
Is allergy normal?




                              ALLERA HEALTH, INC.


Wednesday, May 19, 2010
Allergy is an unwanted outcome of immunity

  •    Mast cells: associated with
       allergy, wound healing,
       patho...
We want to maintain a balance between
                  “helper” T cells (Th)


           Cytotoxicity, autoimmune     An...
What do we observe when there is an
                                 imbalance?
                         one autoimmune ex...
What do we observe as we age?

         Lowered disease fighting         Increased asthma/allergy

                        ...
Published research studies indicate that pinecone
            extract helps to balance your immune system to
             ...
What is pinecone extract?
     Proligna® brand pinecone extract is a patented water
     extract of Scotch pinecones that ...
Manufactured using pure, sustainable
        ingredients–only from Allera Health
     • All U.S. ingredients. Pinecones ar...
Published research shows that pinecone extract
            promotes a balanced “disease-fighting” immune
                  ...
Pinecone extract reduced IgE within two weeks in a pilot clinical
                           study of people with common a...
How to help your immune system
                • Eat less fat and sugar
                • Get enough sleep
               ...
Please remember.....
            Good nutrition will allow you to stay healthy and
            by allowing immune system t...
Immune Extra®
                          Your Once-A-Day Immune Supplement
      • Immune Extra is the only product current...
Immune Extra®
                          Your Once-A-Day Immune Supplement
      • Immune Extra is the only product current...
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Allera Health Products

  1. 1. Allera Health P roducts Developer of patented, all natural, P roligna® pine cone extract, a breakthrough in immune system health ALLERA HEALTH, INC. Wednesday, May 19, 2010
  2. 2. How to increase your immunity to stay healthy! Frank Tufaro, Ph.D. CEO Allera Health Products, Inc. ALLERA HEALTH, INC. Wednesday, May 19, 2010
  3. 3. Infections of major concern 75 years ago.... are somewhat different today... (N. America) 1935 2010 POLIO POLIO SMALLPOX SMALLPOX TUBERCULOSIS TUBERCULOSIS INFLUENZA INFLUENZA HIV MRSA LYME DISEASE ALLERA HEALTH, INC. Wednesday, May 19, 2010
  4. 4. ALLERA HEALTH, INC. Wednesday, May 19, 2010
  5. 5. Proof that our immune system is extremely powerful: ALLERA HEALTH, INC. Wednesday, May 19, 2010
  6. 6. Proof that our immune system is extremely powerful: Vaccines have eliminated or greatly reduced smallpox, polio and other killers through the action of our immune system.... ALLERA HEALTH, INC. Wednesday, May 19, 2010
  7. 7. Proof that our immune system is extremely powerful: Vaccines have eliminated or greatly reduced smallpox, polio and other killers through the action of our immune system.... NO DRUGS REQUIRED! ALLERA HEALTH, INC. Wednesday, May 19, 2010
  8. 8. Proof that our immune system is extremely powerful: Vaccines have eliminated or greatly reduced smallpox, polio and other killers through the action of our immune system.... NO DRUGS REQUIRED! ALLERA HEALTH, INC. Wednesday, May 19, 2010
  9. 9. Unfortunately, new threats emerge to challenge your healthy immune system... • Norovirus causes 23 million cases of acute gastroenteritis annually. Only the common cold is reported more often! • Resistant to common disinfectants (chlorine, freezing) • A healthy immune system is your ONLY DEFENSE since viruses are resistant to all antibiotics ALLERA HEALTH, INC. Wednesday, May 19, 2010
  10. 10. What are the requirements for an effective immune system? •Specific •Potent (fast) •Long-lasting •Safe •Balanced •Everywhere in the body ALLERA HEALTH, INC. Wednesday, May 19, 2010
  11. 11. ALLERA HEALTH, INC. Wednesday, May 19, 2010
  12. 12. Portals of entry... ALLERA HEALTH, INC. Wednesday, May 19, 2010
  13. 13. Portals of entry... Nose breathing in cold and flu, allergens Mouth eating food, virus, bacteria, allergens touching food, bacteria, viruses, allergens Skin (plus hand to mouth/nose transmission) via insects, needles, scratches and Direct bruises, any broken skin ALLERA HEALTH, INC. Wednesday, May 19, 2010
  14. 14. Portals of entry... Nose breathing in cold and flu, allergens Mouth eating food, virus, bacteria, allergens touching food, bacteria, viruses, allergens Skin (plus hand to mouth/nose transmission) via insects, needles, scratches and Direct bruises, any broken skin ALLERA HEALTH, INC. Wednesday, May 19, 2010
  15. 15. Portals of entry... Nose breathing in cold and flu, allergens Mouth eating food, virus, bacteria, allergens touching food, bacteria, viruses, allergens Skin (plus hand to mouth/nose transmission) via insects, needles, scratches and Direct bruises, any broken skin ALLERA HEALTH, INC. Wednesday, May 19, 2010
  16. 16. Portals of entry... Nose breathing in cold and flu, allergens Mouth eating food, virus, bacteria, allergens touching food, bacteria, viruses, allergens Skin (plus hand to mouth/nose transmission) via insects, needles, scratches and Direct bruises, any broken skin ALLERA HEALTH, INC. Wednesday, May 19, 2010
  17. 17. Best remedy: avoid infection! Your first line of defense: ALLERA HEALTH, INC. Wednesday, May 19, 2010
  18. 18. Best remedy: avoid infection! Your first line of defense: •Mucus ALLERA HEALTH, INC. Wednesday, May 19, 2010
  19. 19. Best remedy: avoid infection! Your first line of defense: •Mucus •Stomach acid ALLERA HEALTH, INC. Wednesday, May 19, 2010
  20. 20. Best remedy: avoid infection! Your first line of defense: •Mucus •Stomach acid •Gut bacteria ALLERA HEALTH, INC. Wednesday, May 19, 2010
  21. 21. Best remedy: avoid infection! Your first line of defense: •Mucus •Stomach acid •Gut bacteria •Skin (unbroken) ALLERA HEALTH, INC. Wednesday, May 19, 2010
  22. 22. Best remedy: avoid infection! Your first line of defense: •Mucus •Stomach acid •Gut bacteria •Skin (unbroken) •Tears ALLERA HEALTH, INC. Wednesday, May 19, 2010
  23. 23. Best remedy: avoid infection! Your first line of defense: •Mucus •Stomach acid •Gut bacteria •Skin (unbroken) •Tears •Perspiration ALLERA HEALTH, INC. Wednesday, May 19, 2010
  24. 24. Your immune system also recognizes foreign molecules that arise from within... •Cancer cells express “foreign” molecules •Cancer cells, bacteria and viruses can also block the immune response so that they don’t get destroyed! •Sometimes, your body recognizes your own cells as foreign=autoimmune diseases ALLERA HEALTH, INC. Wednesday, May 19, 2010
  25. 25. Your immune system is a food critic? •70% of your immune system is in your digestive tract •Your immune system must not react to most foods •However, it must fight off dangerous bugs (salmonella!) •Exactly how this works is unknown ALLERA HEALTH, INC. Wednesday, May 19, 2010
  26. 26. Do you recognize these diseases affected by the immune system? •arthritis •coronary artery disease •diabetes •thyroid dysfunction •cancer ALLERA HEALTH, INC. Wednesday, May 19, 2010
  27. 27. Diseases increase as we age and our immune system weakens Arthritis Diabetes Cancer Heart disease 35 40 27 22 26 18 12 15 13 8 16 18 4 45 54 52 3 30 3 2 10 1 3 4 8 0 0 20 35 55 70 80 90 Age (years) ALLERA HEALTH, INC. Wednesday, May 19, 2010
  28. 28. What impacts immunity •Diseases •Pharmaceutical drugs (e.g. chemotherapy) •Genetics •Age •Hygiene (not how you may think!*) *Being too “clean” when we are young may not allow our immune system to learn about our environment. This could cause diseases in later life ALLERA HEALTH, INC. Wednesday, May 19, 2010
  29. 29. Your Immune System ALLERA HEALTH, INC. Wednesday, May 19, 2010
  30. 30. Your Immune System 2 types of immunity: ALLERA HEALTH, INC. Wednesday, May 19, 2010
  31. 31. Your Immune System 2 types of immunity: Innate Immunity (hard wired) ALLERA HEALTH, INC. Wednesday, May 19, 2010
  32. 32. Your Immune System 2 types of immunity: Innate Immunity (hard wired) Acquired Immunity (adaptable) ALLERA HEALTH, INC. Wednesday, May 19, 2010
  33. 33. Your Immune System 2 types of immunity: Innate Immunity (hard wired) Acquired Immunity (adaptable) ALLERA HEALTH, INC. Wednesday, May 19, 2010
  34. 34. Your Immune System 2 types of immunity: Innate Immunity (hard wired) Acquired Immunity (adaptable) Immune cells arising in the bone marrow circulate through the body and some take up strategic positions in the immune organs ALLERA HEALTH, INC. Wednesday, May 19, 2010
  35. 35. Your Immune System 2 types of immunity: Innate Immunity (hard wired) Acquired Immunity (adaptable) Immune cells arising in the bone marrow circulate through the body and some take up strategic positions in the immune organs ALLERA HEALTH, INC. Wednesday, May 19, 2010
  36. 36. Your Immune System 2 types of immunity: Innate Immunity (hard wired) Acquired Immunity (adaptable) Immune cells arising in the bone marrow circulate through the body and some take up strategic positions in the immune organs ALLERA HEALTH, INC. Wednesday, May 19, 2010
  37. 37. Immune cells have specialized roles to play Innate immunity Adaptive immunity (Rapid response) (Slow response) ALLERA HEALTH, INC. Wednesday, May 19, 2010
  38. 38. Innate immunity is inherited Your innate immune system can recognize danger signals through the use of specialized “toll receptors” present on immune cells, and react quickly For example, it knows that bacterial DNA means “danger” and the immune cell alerts your body to the danger ALLERA HEALTH, INC. Wednesday, May 19, 2010
  39. 39. Dendritic cells tell your immune system what to look for Dendritic cells play an important part Dendritic cell in our immune system. They break the antigens on the surface of cancer or infected cells into smaller pieces and then “show” these antigen pieces to the helper T cells, which in turn activate killer T cells to kill the cells that bear these antigens. T cell ALLERA HEALTH, INC. Wednesday, May 19, 2010
  40. 40. Adaptive Immunity Acquired immunity employs many weapons infected cell Cellular Antibodies immunity destroy free destroys microbes (e.g. infected cells, bacteria) cancer cells CD8+ T cell ALLERA HEALTH, INC. Wednesday, May 19, 2010
  41. 41. T-helper cells play a key role... •Stimulate other immune cells to function properly •Possess very powerful and important functions. •Evidence: AIDS patients lose their T-helper cells ALLERA HEALTH, INC. Wednesday, May 19, 2010
  42. 42. T helper cells (continued) Th1- participate in cell-mediated immunity help control viruses and bacteria Th2- help B cells, memory cells and production of IgE antibodies Th17- protect surfaces (skin, gut) against extracellular bacteria ALLERA HEALTH, INC. Wednesday, May 19, 2010
  43. 43. Is allergy normal? ALLERA HEALTH, INC. Wednesday, May 19, 2010
  44. 44. Allergy is an unwanted outcome of immunity • Mast cells: associated with allergy, wound healing, pathogens • Bind IgE antibody • Release histamines and other mediators when activated • Histamine dilates blood vessels, causing signs of inflammation ALLERA HEALTH, INC. Wednesday, May 19, 2010
  45. 45. We want to maintain a balance between “helper” T cells (Th) Cytotoxicity, autoimmune Antibodies, allergy, diseases, graft rejection autoimmune diseases Th1 cell Th2 cell ALLERA HEALTH, INC. Wednesday, May 19, 2010
  46. 46. What do we observe when there is an imbalance? one autoimmune example..... Multiple sclerosis Th1 cell Decreased asthma/allergy Th2 cell ALLERA HEALTH, INC. Wednesday, May 19, 2010
  47. 47. What do we observe as we age? Lowered disease fighting Increased asthma/allergy Th2 cell Th1 cell ALLERA HEALTH, INC. Wednesday, May 19, 2010
  48. 48. Published research studies indicate that pinecone extract helps to balance your immune system to promote health and wellness Pinecone extract Th1 Th2 Immune Balance A L L E R A H E A LTrainingN C . Sales T H , I 2009 Wednesday, May 19, 2010
  49. 49. What is pinecone extract? Proligna® brand pinecone extract is a patented water extract of Scotch pinecones that maintains health and wellness by helping to balance the immune system •Made with a sustainable source of pinecones from the forests of N. America •All natural, vegetarian product manufactured only by Allera Health •Proven safe for people in a double-blind, controlled clinical study •Backed by over 35 independent, peer-reviewed research studies •Protected by 11 patents ALLERA HEALTH, INC. Wednesday, May 19, 2010
  50. 50. Manufactured using pure, sustainable ingredients–only from Allera Health • All U.S. ingredients. Pinecones are readily available as a renewable resource from the forests of Wisconsin and Minnesota • Only purified water is used from start to finish– no alcohol or solvents • All ingredients are 100% natural, vegetarian and free from common allergens or contamination • Highly stable pinecone extract is extensively tested by independent laboratories and measured for potency • Proligna® brand pinecone extract is GMP manufactured in NSF certified facilities. Immune Extra is certified by the Natural Products Association 10 ALLERA HEALTH, INC. Wednesday, May 19, 2010
  51. 51. Published research shows that pinecone extract promotes a balanced “disease-fighting” immune response 300 Mice mount an immune response to a “foreign protein” 225 243 nearly 2.4 fold better when Number of pinecone extract is added to specific disease their drinking water for 2 weeks. 150 fighting T cells produced Equivalent of 1 capsule per day 75 107 for people. 0 (Research performed by scientists at the H. Lee Moffitt Cancer Research Center, a National Cancer Institute control pinecone extract Center of Excellence) 2.4 fold more A L L E R A H E A LTrainingN C . Sales T H , I 2009 Wednesday, May 19, 2010
  52. 52. Pinecone extract reduced IgE within two weeks in a pilot clinical study of people with common allergies IgE (Research performed by scientists Dr. William G. Bradley and Micheal Burrows at the Tampa Bay Research Institute A L L E R A H E A LTrainingN C . Sales T H , I 2009 Wednesday, May 19, 2010
  53. 53. How to help your immune system • Eat less fat and sugar • Get enough sleep • Exercise to increase circulation • Drink plenty of water • Take care of scrapes, burns, bruises • Supplement diet as necessary ALLERA HEALTH, INC. Wednesday, May 19, 2010
  54. 54. Please remember..... Good nutrition will allow you to stay healthy and by allowing immune system to work at its best Allera’s Immune Extra® (Pinecone extract) can help support a balanced “disease-fighting” immune system, even as we age ALLERA HEALTH, INC. Wednesday, May 19, 2010
  55. 55. Immune Extra® Your Once-A-Day Immune Supplement • Immune Extra is the only product currently available with patented Proligna® brand pinecone extract • Expert sales and technical support through in-house staff, website, floor display, literature, and articles • Unique, immune-balancing effects create year-round need for Immune Extra® • Most effective and well researched product in its category • Customers use once-a-day to stay healthy ALLERA HEALTH, INC. Wednesday, May 19, 2010
  56. 56. Immune Extra® Your Once-A-Day Immune Supplement • Immune Extra is the only product currently available with patented Proligna® brand pinecone extract • Expert sales and technical support through in-house staff, website, floor display, literature, and articles • Unique, immune-balancing effects create year-round need for Immune Extra® • Most effective and well researched product in its category • Customers use once-a-day to stay healthy ALLERA HEALTH, INC. Wednesday, May 19, 2010

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