Pr bouchard

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Pr bouchard

  1. 1. Charles Edouard Brown Sequard (1817- 1894)
  2. 2. Science 1997
  3. 3. & GH
  4. 4. GH-IGF1-Insulin <ul><li>1- Les données de la recherche sont sans equivoque. </li></ul>
  5. 5. INSULIN / IGFs Signaling
  6. 6. INSULIN / IGFs Signaling KO GH KO GHRH KO GHR KO KO IGF1 KO IGF1-R KO IRS 1 & 2, PI3 K Yeasts, caenorhabditis elegans, insects, mice & centenarial model
  7. 7. Endocrine Reviews 2011
  8. 8. Des taux bas d ’IGF1 sont associés à une longévité accrue <ul><li>Déficit en GH </li></ul><ul><li>KO des récepteurs de la GH </li></ul><ul><li>KO des récepteurs de l ’IGF1(Bartke A Cur Top Dev Biol 63:189, 2004) </li></ul>
  9. 14. + 18 %
  10. 16. GH-IGF1-Insulin <ul><li>2- Chez l’homme… </li></ul>
  11. 18. Endocrine Reviews 2010, 31: 301-342.
  12. 20. JCEM 18: 901- 903, 1958 NATURE 1979
  13. 21. There is now a substantial body of evidence that indicates that GH Replacement Therapy has a beneficial effect upon many parameters: Body composition improves, lean mass increases, and fat mass decreases sgnificantly. <ul><li>Fasting lipid profile improves with reduction on total cholesterol, LDL </li></ul><ul><li>while HDL increases. </li></ul><ul><li>GHT improves endothelial function as well as the markers of inflammation </li></ul><ul><li>- Carotid IMT also demonstrates a significant improvement during therapy </li></ul>
  14. 22. Swerdlow AJ, Higgins CD, Adlard P, Preece MA 2002 Risk of cancer in patients treated with 17 human pituitary growth hormone in the UK, 1959-85: a cohort study. Lancet 360:273-277 <ul><li>Insulin resistance is Increased </li></ul><ul><li>There is no data demonstrating </li></ul><ul><li>that GHT reduces cardiovascular mortality </li></ul><ul><li>in hypopituitary adults </li></ul><ul><li>- In addition: cancer risk may be increased </li></ul>HOWEVER
  15. 23. JCEM 2012 SAGhE : Safety and Appropriateness of Growth hormone treatments in Europe
  16. 29. Les Fondamentaux <ul><li>« Apprends d’hier, vis pour aujourd’hui, espère pour demain. </li></ul><ul><li>L’important est de ne jamais arrêter de poser des question. » </li></ul><ul><li>Albert Einstein </li></ul>
  17. 30. www.ice-ece2012.com

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