Cell Division: Puzzling Findings Relating To Centromere Structure Reconciled A nucleosome, a short coil of DNA twisted around a core of proteins forms at each centromere. Within the core is a protein, called Cse4 in yeast. But the overall architecture of that nucleosome was unknown. has used live cell imaging to reveal constituents of the centromeric protein core.
Cell Division: Puzzling Findings Relating To Centromere Structure Reconciled• Two methods were combined to probe yeast cells engineered to express Cse4 hooked to a green fluorescent protein (GFP) tag.• The approach allowed them to track and then count in a living cell the number of Cse4 molecules in a centromeric nucleosome.• Yeast cells have 16 chromosomes, each with one centromere. If each centromere contained just one copy of Cse4, then the dot glowing in each cell should be 16 times brighter than a single GFP molecule.
Cell Division: Puzzling Findings Relating To Centromere Structure Reconciled Was found that two evidence molecules of Cse4 were interacting at the centromere in anaphase, but these interactions were not present during the rest of the cell cycle. Is concluded that the timing of structural changes differs in yeast and human cells, But that human and yeast centromeres undergo similar dynamic changes with the cell cycle.
Comment know the functioning of the centromere is important for understanding the segregation of chromosomes and of the consequences of errors in cell division.
Anxiety Linked to ShortenedTelomeres, Accelerated Aging
Anxiety Linked to ShortenedTelomeres, Accelerated Aging A new study shows that a phobic anxiety was associated with shorter telomeres in middle aged and older women.
Anxiety Linked to ShortenedTelomeres, Accelerated Aging Shortened telomeres have been linked to increased risk of cancers, heart disease, dementia and mortality. This study is notable for showing a connection between a common form of psychological stress, phobic anxiety, and a plausible mechanism for premature aging.
Comment See the relationship between a psychological stress with premature aging, is important to give appropriate diagnostic, provide timely treatment using the
MEDICAL UTILITYMost cells in the adultexhibit only limitedtelomerase activity,meaning that as cellsdivide and replicate theirDNA, the chromosomes’telomeres becomeshorter. This limits thenumber of times a cellcan divide andcontributes to aging.
MEDICAL UTILITY Longer telomeres are hypothesized to correlate with improved longevity and reduced disease burden.
MEDICAL UTILITYThe study ofcentromere helpsdetect geneticdiseases whenthere are errors incell division
BIBLIOGRAPHY MARTINEZ S, Lina María, Biología molecular, 7 ed. Medellín: UPB. Fac de Medicina , 2012. 69-70 p. WATSON, James, Biología molecular del Gen, 5 ed. Buenos Aires, Madrid, ed panamericana, 2006. 151-153 p.