A R O M A T I C

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A R O M A T I C

  1. 1. Aromatic Compounds John Robert C. James Daniel Thomas A. Berberabe Mark Angelo N. Siguenza Charles Jervis T. Sy GROUP 4 BSP2A Aromatic Compounds
  2. 2. WHAT ARE AROMATIC COMPOUNDS ??? <ul><li>Class of compounds that contain benzene-like, 6 membered rings with 3 double bonds </li></ul>
  3. 3. Estrone Ibuprofen
  4. 4. BENZENE Should not be used as an laboratory solvent because it causes depressed white blood cell count or Leukopenia on prolonged exposure
  5. 5. History <ul><li>1800 – the formula for benzene ring is C6H6 </li></ul><ul><li>Relatively unreactive towards most reagents that attack alkenes </li></ul><ul><li>It reacts with bromine in the presence of Iron to give the SUBSTITION product </li></ul>C6H6 + Br2  C6H5Br
  6. 6. AUGUST KEKULE Proposed in 1865 that benzene contains a ring of carbon atoms
  7. 7. Properties of Aromatic Compounds <ul><li>with aroma </li></ul><ul><li>will burn with a smokey yellow flame due to incomplete carbon combustion </li></ul><ul><li>hydrophobic or water hating </li></ul><ul><li>non-polar </li></ul><ul><li>dissolves organic substance but insoluble with water </li></ul><ul><li>can interact with other aromatic compounds by Intermolecular bonding by Van der Waals forces of attraction </li></ul>
  8. 8. Properties of Aromatic Compounds <ul><li>unusually stable </li></ul><ul><li>type of reaction : electrophilic substitution </li></ul><ul><li>less dense than water </li></ul>
  9. 9. Many drugs contain aromatic compounds. Codeine, for example, is a powerful analgesic or pain reliver.
  10. 10. Application of Aromatic Compounds in Medicine ASPIRIN Acetyl-Salicylic Acid
  11. 11. CODEINE

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