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Stem cell treatment Joints India


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Biological treatments are the latest advance in Orthopedic surgery. They can heal a range of tissues without surgery. Dr.Venkatachalam offers these procedures in Chennai. Dr.Venkatachalam offers stem cell treatment for knee OA, AVN hip, shoulder OA and other musculoskeletal conditions. Visit

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Stem cell treatment Joints India

  1. 1. Dr.A.K.Venkatachalam MS Orth, DNB Orth, FRCS, M.Ch Orth Specialist in Arthroplasty, Joint preservation & Regenerative medicine Guest hospital E mail- Orthopedic Biological treatments
  2. 2. Goal in Regenerative medicine  To recreate original tissue  Pain relief  Preserve joint function
  3. 3. Cartilage  It is the lining tissue at the end of bones  It acts as a shock abosrber.  Wears down due to number of factors.  Gives rise to pain, grinding, catching when worn out.
  4. 4. Final condition is Osteo-arthritis  Osteo-arthritis is a joint failure.  Has epidemic proportions in India and world wide.  In India, Knee OA is commonest.  Final treatment is Knee replacement when non operative measures have failed.
  5. 5. Environment within OA joint  Presence of signals which promote inflammation, suppress cartilage synthesis.  Progenitor stem cells present in joint fluid which is not present in normal cartilage.
  6. 6. Biological therapy  Growth factors derived from Platelets. Platelet rich plasma.  Adult mesenchymal stem cells. ( Medicinal signalling cells) may be a better name.  Others- Human Embryonic stem cells, Inducible progenitor stem cells.
  7. 7. Stem cells  Pluripotent stem cells –They're able to make cells from all three basic body layers, so they can potentially produce any cell or tissue the body needs to repair itself.  Multipotent stem cells are cells that have the capacity to self-renew by dividing and to develop into multiple specialised cell types present in a specific tissue or organ. Most adult stem cells are multipotent stem cells.  Multi potent stem cells are more limited than pluripotent cells.
  8. 8. Adult Mesenchymal cell therapy  Mesenchymal cells can be obtained from bone marrow, adipose tissue, synovial fluid, umbilical cord  Have potential to differentiate into cartilage.  Act by recruiting growth factors, chondrogenesis.
  9. 9. Source of stem cells – bone marrow
  10. 10. Bone marrow technique  Bone marrow aspiration  Centrifuging  Bone marrow concentrate
  11. 11. Conclusion  Osteo-arthritis is very common in India and abroad  OA knee is commonest.  Cell based treatments are most promising to restore normalcy.  Early results are encouraging. Pain relief is certain. Grinding sensation takes time to disappear. MRI evidence takes time to appear.