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Mc qsof 22.02

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toxicology is a very important topic for pg entrance.....so all about it has been discussed in detail as required for pg entrance....do make use of it...

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Mc qsof 22.02

  1. 1. 1) Magnesium sulphate lavage is done in poisoning with: A Aniline B Copper sulphate C Ethyl Alcohol D Sulphuric acid
  2. 2. Ans. A Aniline Aniline- Magnesium sulphate, CuSo4- 1% Pot ferrocyanide, Sulphuric acid- C/I,
  3. 3. 2.Q. Pupil is pin-point in poisoning due to: A Opium (Morphine) B Dhatura C Cocaine D Amphetamine
  4. 4. Ans. A Opium (Morphine)
  5. 5. F = Formaldehyde B = Barbiturates . C =Carbolic Acid O = Organophosphorus M = Opium
  6. 6. 3.Q. ‘Phossy jaw’ is seen in poisoning with: A Mercury B Lead C White phosphorus D Barium
  7. 7. C) White phosphorus
  8. 8. White Red Protoplasmic Poison -Non toxic -No smell -Non luminous -Yellow phosphorus = white+ Red -Garlicky smell : Also seen in Celphos and arsenic poisoning -Phossy Jaw -Antidote : CuSO4 - BUT NOT TO BE USED ORALLY SINCE IT ITSELF IS A POISON Rx 1) Vit.K 2) HEMODIALYSIS
  9. 9. 1) Phosphorus : MC 2) Mercury 3) Strontium 4) Antimony 5) Arsenic FOUND IN CRACKERS
  10. 10. POTASSIUM CHLORATE + ANTIMONY SULPHATE
  11. 11. Phossy jaw, formally phosphorus necrosis of the jaw, is an occupational disease of those who work with white phosphorus. It was most commonly seen in workers in the match-stick industry
  12. 12. 4.Q. Preservative used for samples for alcohol poisoning is: A Formalin B Methyl alcohol C Saturated solution of NaCI D 10% carbolic acid
  13. 13. (Preservatives used in poisoning cases & Rabies- - All poisoning cases = saturated soln. of common salt( MC used preservative) - Acid poisoning- rectified spirit (95%ethanol + 5% methanol), EXCEPT- Carbolic acid- Thymol. - Blood for Alcohol- NaF. - Urine- Thymol. - Faeces- rectified spirit. -Rabies- 50% glycerol saline, - VIROLOGICAL : 80%GLYCERINE -Histopathology = formalin /alcohol -Anatomical specimen = 40% formalin C Saturated solution of NaCI
  14. 14. Blood = 100ml Urine = 100ml Liver = 500gm Intestine = 30cm Half kidney both sides
  15. 15. 5.Q. Arsenic poisoning’ is distinguished from ‘Cholera’ by: A Voice change B Pain in throat after vomiting C Tenesmus & anal irritation present D Burning sensation preceding vomiting
  16. 16. C) Tenesmus & anal irritation present
  17. 17. 6. The treatment of Methyl alcohol poisoning includes all EXCEPT: A Haemodialysis B Treatment of acidosis C Ethyl alcohol D Inj. Vit B12 in large doses
  18. 18. D Inj. Vit B12 in large doses
  19. 19. 7. Organophosphorus poisoning is characterised by all EXCEPT: A Excessive salivation B Excessive sweating C Bronchoconstriction D Fixed and dilated pupil
  20. 20. Ans. D Fixed and dilated pupil (Organophosphorus poisoning- SLUDGE- Salivation, Lacrimation, Urination, Diarrhoea, GIT distress, Emesis, Constricted pupils.
  21. 21. 8. All are features of Atropine poisoning EXCEPT: A Dry skin B Miosis C Delirium D Dry eye
  22. 22. Ans. B Miosis Atropine poisoning involves Mydriasis not miosis Atropine poison means Dhatura poisoning, the chief signs & symptoms of Dhatura poisoning are- Hot as a hare, Blind as a bat, Dry as a bone, Red as a beet, Mad as a wet hen, Dilated pupils.
  23. 23. 9.Q. Mucous membrane of stomach is dark-brown or black in poisoning due to: A Sulphuric acid B Nitric acid C Oxalic acid D Carbolic acid
  24. 24. Ans. A Sulphuric acid Colour of mucosae in various corrosives- 1. Sulphuric acid = H2SO4 = Oil of vitriol; tongue swollen and black or dark-brown. 2. Nitric acid (aqua fortis) - Xanthoproteic reaction- yellow discolouration due to picric acid. 3. Carbolic Acid = Phenol. a. Carbolism- white opaque eschar. b. Carboluria= green urine.
  25. 25. -Oil of Vitriol -Vitriolage : Throwing corrosive on another person -MC symptom dur to ingestion : Pharyngeal Pain -Brown discoloration of stomach -Only local symptoms…no systemic effects -Maximum chance of stomach perforation among all corrosives -Mucosa will be burnt : Bloating Paper appearance -Gastric lavage and alkali administration is contra indicated -Antidote = MgO
  26. 26. -PHENOL -Only corrosive where gastric lavage can be done. -Metabolites : Pyrocatechol Hydroquinone -Ochronosis : Hydroquinone deposits in cartilages. -Carboluria : Both metabolites when excreted in urine gives Green colour -Delays decomposition -Causes miosis -Fatal dose : 1-2ml -Fatal period: 3-4hrs Mnemonic : 1-2-3-4
  27. 27. -Acid of Sugar/ Acid of Sorrel -Presnt in Tomato/ Cabbage/ Spinach -Oxalate reacts with calcium and thus causes Hypocalcemia -Used as Ink remover -Coffee ground vomiting: Blood + vomiting -Antidote: Calcium Gluconate Coffee ground vomiting
  28. 28. -Aqua Fortis -Gives brown color to urine -Xanthoproteic reaction : Skin becomes Yellow -Brown mucosa
  29. 29. Seen in Boric Acid Poisonings
  30. 30. 10. Gastric walls are whitish, leathery in poisoning due to: A Sulphuric acid B Nitric acid C Carbolic acid D Hydrochloric acid
  31. 31. C Carbolic acid
  32. 32. 11. Perforated nasal septum may be due to overdose poisoning due to: A Anticholinergics B Solvent abuse C Cocaine abuse D Methanol
  33. 33. C Cocaine abuse
  34. 34. -CNS Stimulant -Mech. ; Dopamine/Serotonin/Nor epinephrine -Vasoconstrictor -Derives from leaves of erythoxylum cocca -Tactile hallucinations: also k/a Cocaine bugs/magnan bugs -Paranoid delusions : is the fixed, false belief that one is being harmed or persecuted by a particular person or group of people. -If sniffed can cause Nasal septum perforation -On oral intake : Black jet tongue -Antidote = Amyl Nitrate
  35. 35. 12. Both hepatic and renal failures can be caused by which of the following: A Paracetamol toxicity B Carbon tetrachloride C Arsenic D Copper sulphate E Silver nitrate
  36. 36. Ans. D Copper sulphate PCM, CCl4, AgNO3 - liver failure. As - kidney failure. CuSO4- both hepatic & Renal failure. CuSO4 CuSO4 even though poison is used as antidote for phosphorus poisoning But not to be given orally as an antidote. -Green line on gums -Golden colour hairs -Ptysalism : increase salivation
  37. 37. 13. ‘Charas’ is: A Leaves of Cannabis indica B Flowers of Cannabis indica C Stem of Cannabis indica D Resin exudates of cannabis indica
  38. 38. D Resin exudates of cannabis indica
  39. 39. -Principle : 9-tetra-hydro-cannabinol -Leaves = Bhang -Stem exudate = charas -Female flower top= Ganja -Sweet = Majoon - Burnt rope smell -Antidote : Diazepam -Run amok : Psychiatric problem -Amotivational syndrome
  40. 40. Leaves = Bhang Stem exudate = charas
  41. 41. 14. Hyperbaric Oxygen is used in which of the following: A Carbon monoxide poisoning B ARDS C Anaerobic infection D Pneumonia
  42. 42. A Carbon monoxide poisoning
  43. 43. Carbon monoxide poisoning -Safety limit in air = 0.01% -Muscle weakness = 4% -Alcohol intoxication features = 50% -Coma and death = 60% -Cherry red colour postmortem discoloration -Lenticular nucleus necrosis -Rx 1) hyperbaric O2 2) Vitamin E
  44. 44. 15. Sodium fluoride may be used for preservation of: A Cyanide B Arsenic C Alcohol D Urine
  45. 45. C Alcohol NaF is used for preserving alcohol in blood and glucose in blood.
  46. 46. (Preservatives used in poisoning cases & Rabies- - All poisoning cases = saturated soln. of common salt( MC used preservative) - Acid poisoning- rectified spirit (95%ethanol + 5% methanol), EXCEPT- Carbolic acid- Thymol. - Blood for Alcohol- NaF. - Urine- Thymol. - Faeces- rectified spirit. -Rabies- 50% glycerol saline, - VIROLOGICAL : 80%GLYCERINE -Histopathology = formalin /alcohol -Anatomical specimen = 40% formalin C Saturated solution of NaCI
  47. 47. 16. A bus passenger who was offered sweets by a co-passenger presented with dilated pupils and facial flushing after being duped. He was duped with: A Cocaine B Belladonna C Dhatura D Opium
  48. 48. C Dhatura
  49. 49. Dhatura poisoning Hot as a hare, Blind as a bat, Dry as a bone, Red as a beet, Mad as wet hen. Pyrexia + contracted pupils = Phenobarbitone poisoning; Pyrexia + dilated pupils = Datura poisoning.
  50. 50. -Principle : Hyoscine/Atropine/Hyoscyamine/Scopola -So all anti-cholinergic effects are seen -Lethal Dose = 100-125seeds -Seeds resembles chilly seeds Antidote: Physostigmine/Pilocarpine
  51. 51. DATURA SEEDS CHILLY SEEDS
  52. 52. 17. Atropine is used for following EXCEPT: A Organophosphorous poisoning B Mushroom poisoning C Physostigmine overdose D Glaucoma
  53. 53. D Glaucoma Atropine is contraindicated in Glaucoma and indicated for the treatment of Organophosphorus poisoning, Mushroom poisoning & Physostigmine overdose.
  54. 54. 18. To preserve specimen, concentration of formalin used is: A 1% B 5% C 10% D 40%
  55. 55. Ans. C 10% Specimens for pathological examination and Museums specimens are preserved in 10% Formalin. Formalin is ordinarily available as a 40% solution from the market, it is diluted to 10% for use in preservation of specimens. Formalin is never used to preserve toxicological specimens as it would denature the poisons and make the estimation of poisons difficult.)
  56. 56. 19. Most Specific test for Organophosphorus poisoning: A Plasma cholinesterase B RBC cholinesterase C Acetylcholine at myoneural junction D Histochemistry
  57. 57. A Plasma cholinesterase
  58. 58. 20. Acrodynia is seen in: A Lead poisoning B Mercury poisoning C Cyanide poisoning D Tin poisoning
  59. 59. B Mercury poisoning
  60. 60. -Donovan solution = Mercury + Arsenic -MC mercuric salt causing poisoning is = HgCl2 Mu = Minimata Disease Mmy = Mercuria Lentis H = Hatter Shake E = Erethism A = Acrodynia D = Danbury Tremors - Blue-Black line on gums.
  61. 61. MINIMATA DISEASE Minimata disease, is a neurological syndrome caused by severe mercury poisoning. Symptoms include ataxia, numbness in the hands and feet, general muscle weakness, narrowing of the field of vision and damage to hearing and speech.
  62. 62. MINIMATA DISEASE
  63. 63. MERCURIA LENTIS -deposition of brown pigment on anterior lens capsule without affecting visual acuity. - Brown malt reflex.
  64. 64. HATTER SHAKE Tremor (Intentional, coarse, affecting arms, hands, tongue and later legs, also called hatter's shake/glass blower's shake/danbury tremors) ERETHISM Erethism : Psychological disturbance characterised by shyness, timidness, loss of memory, depression, insomnia.
  65. 65. Acrodynia (Pink disease, characterised by pain, paraesthesia, pinkish discolouration of hands and feets)
  66. 66. 1) Lead 2) Mercury 3) Iron 4) copper

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