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Types of Bioreactors / Fermenters

The heart of the fermentation or bioprocess technology is the Fermentor or Bioreactor. A bioreactor is basically a device in which the organisms are cultivated to form the desired products. it is a containment system designed to give right environment for optimal growth and metabolic activity of the organism.
A fermentor usually refers to the containment system for the cultivation of prokaryotic cells, while a bioreactor grows the eukaryotic cells (mammalian, insect cells, etc).

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Types of Bioreactors / Fermenters

  1. 1. Types of Bioreactor / Fermenter Powerpoint Templates Page 1
  2. 2. Bioreactor / Fermenter A bioreactor is basically a device in which the organisms are cultivated to form the desired products. It is a containment system designed to give right environment for optimal growth and metabolic activity of the organism. Powerpoint Templates Page 2
  3. 3. Bioreactor / Fermenter Powerpoint Templates Page 3
  4. 4. Types of Bioreactors • • • • • • • • Stirred Tank Bioreactor Airlift Bioreactor Packed Bed Bioreactor Fluidized Bed Bioreactor Photo Bioreactor Membrane Bioreactor Rotary Drum Bioreactor Mist Bioreactor Powerpoint Templates Page 4
  5. 5. Stirred Tank Bioreactor Powerpoint Templates Page 5
  6. 6. Advantages of Stirred Tank Bioreactor • • • • • • • Continuous operation. Good temperature control. Easily adapts to two phase runs. Good control. Simplicity of construction. Low operating cost. Easy to clean. Powerpoint Templates Page 6
  7. 7. Disadvantages of Stirred Tank Bioreactor • • The need for shaft seals and bearings. Size limitation by motor size, shaft length & weight. Powerpoint Templates Page 7
  8. 8. Airlift Bioreactor Powerpoint Templates Page 8
  9. 9. Advantages of Airlift Fermenter • • • • • Simple design Easier sterilization (no agitator shaft parts) Low Energy requirement vs stirred tank Greater heat-removal vs stirred tank Very low cost Powerpoint Templates Page 9
  10. 10. Disadvantages of Airlift Fermenter • Greater air throughput and higher pressures needed. • Inefficient break the foam when foaming occurs. • NO bubbles breaker Powerpoint Templates Page 10
  11. 11. Packed Bed Bioreactor Powerpoint Templates Page 11
  12. 12. Advantages of Packed Bed Reactor • Higher conversion per unit mass of catalyst than other catalytic reactors • Low operating cost • Continuous operation • No moving parts to wear out • Catalyst stays in the reactor • Reaction mixture/catalyst separation is easy • Effective at high temperatures and pressures Powerpoint Templates Page 12
  13. 13. Disadvantages of Packed Bed Reactor • • • • • Undesired heat gradients Poor temperature control Difficult to clean Difficult to replace catalyst Undesirable side reactions Powerpoint Templates Page 13
  14. 14. Fluidized Bed Bioreactor Powerpoint Templates Page 14
  15. 15. Advantages of Fluidized Bed Reactor • Uniform Particle Mixing: • Uniform Temperature Gradients • Ability to Operate Reactor in Continuous State Powerpoint Templates Page 15
  16. 16. Disadvantages of Fluidized Bed Reactor • Increased Reactor Vessel Size • Pumping Requirements and Pressure Drop • Particle Entrainment • Lack of Current Understanding • Erosion of Internal Components • Pressure Loss Scenarios Powerpoint Templates Page 16
  17. 17. Photo Bioreactor Powerpoint Templates Page 17
  18. 18. Advantages of Photobioreactor • • • • Higher productivity Large surface-to-volume ratio Better control of gas transfer. Reduction in evaporation of growth medium. • More uniform temperature. Powerpoint Templates Page 18
  19. 19. Disadvantages of Photobioreactor • Capital cost is very high. • The productivity and production cost in some enclosed photobioreactor systems are not much better than those achievable in open-pond cultures. • The technical difficulty in sterilizing Powerpoint Templates Page 19
  20. 20. Membrane Bioreactor Powerpoint Templates Page 20
  21. 21. Advantages of membrane bioreactor • The loss of enzyme is reduced. • Enzyme lost by denaturation can be made up by periodic addition of enzyme. • Substrate and enzyme can be easily replaced. Powerpoint Templates Page 21
  22. 22. Rotary Drum Bioreactor Powerpoint Templates Page 22
  23. 23. Advantages of Rotary Drum Reactor • High oxygen transfer. • Good mixing facilitates better growth and impart less hydrodynamic stress. Powerpoint Templates Page 23
  24. 24. Disadvantages of Rotary Drum Reactor • Difficult to scale up. Powerpoint Templates Page 24
  25. 25. Mist Bioreactor Powerpoint Templates Page 25
  26. 26. Advantages of Mist Bioreactor • High oxygen transfer. • Hydrodynamic stress elimination. • Low production cost. Powerpoint Templates Page 26
  27. 27. Disadvantages of Mist Bioreactor • Mesh trays and cylindrical stainless steel meshes are required Powerpoint Templates Page 27
  28. 28. Click here to read more on Types of Biore Powerpoint Templates Page 28