Single Use Bioreactor

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http://technologyinscience.blogspot.com/2013/07/single-use-bioreactor-types-advantages.html

A single-use bioreactor (S.U.B) or disposable bioreactor is a bioreactor with a disposable bag instead of a culture vessel.

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Single Use Bioreactor

  1. 1. Single Use Bioreactors Bio-Resource www.technologyinscience.blogspot.com
  2. 2. Single Use Bioreactor • A single-use bioreactor (S.U.B) or disposable bioreactor is a bioreactor with a disposable bag instead of a culture vessel made from stainless steel or glass.
  3. 3. Types of Single Use Bioreactors Stirrer Type Rocking Motion Type
  4. 4. Advantages of Single Use Bioreactors • Eliminates validation issues because the cleaning process is avoided. • Shortens downtime and turnaround time because no cleaning is required. • Lowers risk of cross-contamination with use of new bags for each run. • Offers multiple advantages based on the elimination of the cleaning process. • Decreased operating costs and capital investment: savings on start- up capital costs as well as utilities, space, and labor requirements. • Cost savings from reduced cleaning • Validation is reduced because systems are less complex. • Ease of installation. • Ease of moving when empty.
  5. 5. Disadvantages of Single Use Bioreactors • Limitation in liquid transfer. • Scalability is an issue. • Expensive to use. • Performance is not completely proven. • Slight increase in variable costs per run. • Leachables and inability to store hot liquids. • Potential for puncture. • Difficulty in moving when full. • Pressure and temperature sensitivity. • Disposal costs.
  6. 6. Progress for Single Use Bioreactor • Wide acceptance of bioprocess bags • Single use bioreactors are scalable and performance is comparable to Stainless Steel bioreactors. • 1000L Bioreactor scales can open up opportunitiesin commercial applications.
  7. 7. List of Commercially available Single Use Bioreactor Systems • XDR - Xcellerex • Mobius - Millipore • CelliGen BLU - eppendorf • Hyclone S.U.B - Thermo Scientific • Single Use Bioreactor – Applikon
  8. 8. Thank You Bio-Resource http://technologyinscience.blogspot.com/2013/07/single-use- bioreactor-types-advantages.html

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