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  1. 1. OSTEOBLAST RESPONSE TO INDIGENOUSDEMINERALISED BONE MATRIX
  2. 2. Presentation by Dr.S. Thanga Kumaran Post graduate Ragas Dental College & Hospital ChennaiGuided by Dr .K.V.Arun M.D.S., Department of Periodontics Ragas Dental College & Hospital Chennai
  3. 3. • Regeneration of lost periodontal apparatus is the ultimate goal of periodontal therapy.• Bone replacement graft’s(BRG) have been widely used to achieve this regeneration with varied results.• Osteo inductive bone grafts are thought to be clinically superior because of their ability to induce new bone formation from uncommitted progenitor cells.
  4. 4. Experimental evidence of osteo induction have come from the following1. Animal studies showing ectopic bone formation following subcutaneous and intramuscular implantation of osteoinductive grafts (Zhang et al)2. In vitro studies of osteoblastic and osteoclastic proliferation following exposure to inductive material.
  5. 5. BONE MARROW ISOLATION
  6. 6. BONE MARROW TRANSFER
  7. 7. CELL PROLIFERATION
  8. 8. CONTROL
  9. 9. OSSEOGRAFT
  10. 10. GRAFTON
  11. 11. CELL PROLIFERATIONCONTROL CONTROL GRAFTON OSSEOGRAFT
  12. 12. CELL PROLIFERATION CONTROL OSSEOGRAFT GRAFTONDAY 5 ++ + ---DAY 7 ++ ++ ++DAY 8 ++ +++ +++
  13. 13. CELL DIFFERENTIATION
  14. 14. CONTROL
  15. 15. OSSEOGRAFT
  16. 16. GRAFTON
  17. 17. CELL DIFFERENTIATIONCONTROL GRAFTON OSSEOGRAFT
  18. 18. ALKALINE PHOSPHATASE (ALP) ACTIVITY GraftonControl Osseograft Grafton
  19. 19. CONCLUSION
  20. 20. Grafton and osseograft bothhave the potential for stimulatingosteoblastic proliferation anddifferentiation fromundifferentiated mesenchymalcells and hence both are trulyosteoinductive in nature.

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