Drug treatment of epilepsy

1,245 views

Published on

MBBS

Published in: Education, Health & Medicine
3 Comments
3 Likes
Statistics
Notes
  • I had my first seizure. I was in high school and didn't want anyone to know that I had epilepsy. I had seizures on two occasions. I was so ashamed and didn't want people to think that something was wrong with me. I finally got to the point where I told people that I had epilepsy. I came to the place that I realized that I had to own my epilepsy or it would control me. Epilepsy hadn't really affected my life until about 9 years ago after my first child was born... I am a wife and mother of two beautiful children. I have lived with epilepsy for 20 years Yet, my life has been dramatically impacted by epilepsy. I had search for cure online without no hope. I met a Man called DR Lewis hill, i contact him I made an order of his medicine and I do not experience seizure anymore i was cured form it. So if you are in the same situation as mine contact him on this email drlewishill247@gmail.com
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • Am One of the happiest woman on earth since my son was cured from the problem of seizure,which he has been having for eight years now,he do have the attack two to three times a week,which is affecting is education and his life.i got the contact of a doctor from the post of one Mr smith thanking he for curing his seizure problem,i got the contact and contacted him then he made me to know that the medication is a permanent cure, and that was how i got the medication which i used on my son,and for six month now there have been no sign of seizure in him again.any one with such problem can contact him on his email drwilliams098765@gmail.com
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • I had an epileptic fit for the first time 5 years ago in the middle of supermarket on my birthday of all days, wasn't fun for my kids to see it, it still haunts, I've tried many anticonvulsants and had never been able to stop the seizures. Surgery was not an option. I was still an epileptic patient, who have completely lose hope. As the problem is always embarrassing and disturbing. While surfing the internet one fateful day, I learned about Doctor on the internet called Lawson . I contacted him with some info and I ordered for the Herbal medication and used the medication for 6 months, though hesitantly, considering the fact that I have done a lot of procedure. After which I went for medical test It worked! I've been seizure free, Over a year now, I have not show any symptoms of seizure and I believe I am cure if you want to contact him at this email dr.lawson52@gmail.com.
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
No Downloads
Views
Total views
1,245
On SlideShare
0
From Embeds
0
Number of Embeds
3
Actions
Shares
0
Downloads
60
Comments
3
Likes
3
Embeds 0
No embeds

No notes for slide

Drug treatment of epilepsy

  1. 1. Dr AELIYA ZAIDI HOUSE OFFICER MEDICAL UNIT ll HFH,Rwp March 25th, 2006
  2. 2. DRUG TREATMENT OF EPILEPSY
  3. 3. SEIZURES • Any abnormal clinical event caused by an electrical discharge from the brain.
  4. 4. EPILEPSY • Tendency to have seizures. • Symptom of a brain disease tan disease itself. • Single seizure is not epilepsy. • In a group of disorders,it is the only or main symptom,in others,its just one of the manifestations.
  5. 5. CLASSIFICATION • • 1)SEIZURE TYPE Simple partial Complex partial Absence Tonic Clonic Tonic Atonic Myoclonic 2)ELECTROPHYSIOLOGY Focal spikes/sharp waves Generalized spikes & waves • 3)ANATOMICAL a: CORTEX Frontal Temporal Parietal Occipital b:GENERALISED Diencephalon c:MULTIFOCAL 4)PATHOLOGICAL CAUSES
  6. 6. MANAGEMENT • Explain the nature & cause of seizures to the relatives. • Immediate care. • Restrictions. • Anticonvulsant drug therapy.
  7. 7. ANTICONVULSANT DRUG THERAPY
  8. 8. GUIDELINES FOR ANTICONVULSANT THERAPY • Start with one 1st line drug. • Start with low dose;gradually increase to effective control of seizures or side effects.If 1 st drug fails,start 2nd line drug whilst gradually withdrawing 1st. • Try 3 agents singly before using combinations. • Do not use more than 3 drugs in combination. • If above fails.consider occult structural or metabolic cause.
  9. 9. CHOICEOF AED Epilepsy Type 1st LINE 2nd LINE 3rdLINE Partial&/2n Carbamaze Lamotrigine dry GTCS pine Topiramate Valproate Phenytoin Gabapentin Clobazam Primidone Phenobarb Vigabatrin Myoclonic Phenobarbi tone Valproate Clonazepa m
  10. 10. CHOICEOF AED PRIMARY GTCS VALPROA TE CARBAMA ZEPINE LAMOTRIG INE TOPIRAMA TE ABSENCE ETHOSUXI VALPROA MIDE TE PHENYTOI N GABAPEN TIN PHENOBA RBITONE LAMOTRIG INE CLONAZE PAM
  11. 11. AED’S DRUG Seizure Type Dose range mg/day Doses/ day Carbama Partial/2n 200-2000 2-3 zepine dry GTCS Clonaepa Partial 1-8 m Myoclonu s 2 Ethosuxi Childhoo 500-1500 2 mide d Absence Therapeu tic range 30-50 _ 200-700
  12. 12. AED’S Primidon Partial e 2ndry GTCS 2501000 1-2 50-150 Lamotrig ine _ 25-500 1-2 NA Phenoba rbitone _ 60-180 1 50-150 Phenytoi n _ 150-300 1 40-80 Topiram ate _ 200-600 1-2 NA
  13. 13. Valproat Primary 400e 2ndry 2500 GTCS, Absence Myoclon us 1-2 NA Gabapen Partial til 3 NA 1-2 NA 3002400 Vigabatri Partial 2000n 2ndry 6000 GTCS,Inf antile spasms
  14. 14. ANTICONVULSANT DRUG BLOOD LEVELS • Can be a useful guide in case of some drugs. • In valproate,no relationship b/w level & anticonvulsant efficacy. • Particularly useful in phenytoin & carbamazepine.
  15. 15. WITHDRAWL OF AED’S • Can be considered after complete control of seizures for 2-4 years. • Should be undertaken slowly, reducing the drug dose gradually over 6-12 months.
  16. 16. OUTCOME AFTER 20 YEARS • 50% seizure free, without drugs for last 5 years. • 20% seizure free for last 5 years but continue to take medication. • 30% seizures continue in spite of anti epileptic therapy.
  17. 17. THANKYOU

×