Side Effects of Psychotropics              By     AHMED ALBEHAIRY,M.D  PSYCHIATRY CONSULTANT, MOH
Important items in S.E of    psycho tropics Acting on many neurotransmitters, localized to  many organs. Categorizations...
SE caused by blockade ofmuscarinic Ach     Blurred vision.     Constipation.     Decreased salivation, sweating.     D...
Antdopaminergic SE  Hyperprolactinemia.  Menstrual dysfunction.  Sexual dysfunction.  Akathesia.  Dystonia.  Parkins...
Antiadrenergic ( a1)   Dizziness.   Postural hypotension.   Reflex tachycardia.
antihistaminergic   Sedation   Weight gain.
Excessive serottonergic   Akathesia, agitation.   Anxiety.   GIT upset and diarrhea.   Headache.   Insomnia or somnol...
Multiple neurotransmittersystem   Agranulocytosis .   Allergic reactions.   Anorexia.   Cardiac conduction abnormaliti...
Monoamine receptors : review    5HT1A-----AD,ANXIOLYTIC.    5HT1B-----ANIMAL MODEL OF 5HT1DB    5HT1Da---ANTIMIGRAINE ...
Monoamine receptors : review  H1 ANTAG---- SEDATION,WT GAIN.  H2 ANTAG----TTT OF PEPTIC ULCER  H3 ANAG-----INC   ARROUS...
Monoamine receptors : review  D1----D1 &D2 SYNERGISM, COCAINE   EFFECT  D2---- EPS,ANTIPSYCHOTIC  D3---UK  D4---S-D AN...
Monoamine receptors : review    A1,a,b,c antagonist---antihypertensive    A2 agonist------sedative ,antihypertensive   ...
Treatment of common SE    Sexual dysfunction.    Anxiety, akathesia,insomnia.    GIT upset.    Headache.    Anorexia....
Common SE of lithium  Tremors:--- dec dose, indral  GIT UPSET– dec dose  Wt gain---adj wt loss, warn in advance  Cogni...
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Side effects of psychotropics

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Side effects of psychotropics

  1. 1. Side Effects of Psychotropics By AHMED ALBEHAIRY,M.D PSYCHIATRY CONSULTANT, MOH
  2. 2. Important items in S.E of psycho tropics Acting on many neurotransmitters, localized to many organs. Categorizations of side effects according to the action on neurotransmitter system. ??? Several SE have nt been ,neurotransmitters, specifically identified. Drug induced syndrome, movements. Expectation of SE , dec. trouble . Treatment of SE. Choose the treatment according to SE.
  3. 3. SE caused by blockade ofmuscarinic Ach  Blurred vision.  Constipation.  Decreased salivation, sweating.  Delayed or retrograde ejaculation.  Delirium.  Exacerbation of asthmatic pts.  Hyperthermia.  Memory problems.  Narrow angle glaucoma.  photophobia,.  Sinus tachycardia.  Urinary retension.
  4. 4. Antdopaminergic SE  Hyperprolactinemia.  Menstrual dysfunction.  Sexual dysfunction.  Akathesia.  Dystonia.  Parkinsonism.  T dyskinesia.
  5. 5. Antiadrenergic ( a1)  Dizziness.  Postural hypotension.  Reflex tachycardia.
  6. 6. antihistaminergic  Sedation  Weight gain.
  7. 7. Excessive serottonergic  Akathesia, agitation.  Anxiety.  GIT upset and diarrhea.  Headache.  Insomnia or somnolence.  Nausea  Sexual dysfunction
  8. 8. Multiple neurotransmittersystem  Agranulocytosis .  Allergic reactions.  Anorexia.  Cardiac conduction abnormalities.  Seizures.
  9. 9. Monoamine receptors : review  5HT1A-----AD,ANXIOLYTIC.  5HT1B-----ANIMAL MODEL OF 5HT1DB  5HT1Da---ANTIMIGRAINE  5HT1DB,1F---ANTIMIGRAINE  5HT2A------ATYPICAL ANTIPSYCHOTICS  2B---- STOMACH CONTRACTION  2C--- REGULATION OF APPETTITE,SEIZURE, ANTIPSYHOTIC  5HT3----ANTEMETIC,ANXIOLYTIC,COGNITIVE ENHANCER  5HT4----MODULATION OF COGNITION  5HT6--- ATYPICAL ANTIPSYCHOTIC  5HT7 --- REGULATION OF C RYTHM
  10. 10. Monoamine receptors : review  H1 ANTAG---- SEDATION,WT GAIN.  H2 ANTAG----TTT OF PEPTIC ULCER  H3 ANAG-----INC ARROUSAL,APPETITE SUPRESSION.
  11. 11. Monoamine receptors : review  D1----D1 &D2 SYNERGISM, COCAINE EFFECT  D2---- EPS,ANTIPSYCHOTIC  D3---UK  D4---S-D ANTAGONIST, ATYPICAL ANTIPSYCHOTICS.  D5---- UK
  12. 12. Monoamine receptors : review  A1,a,b,c antagonist---antihypertensive  A2 agonist------sedative ,antihypertensive  B1---- cardic function  B2--- br athma  B3--- adipose tissue function  M1--- cognition,seizures  M2---- cardiac function  M3 --- smooth ms contraction  M4---- antparkinsonism,anticholinergic
  13. 13. Treatment of common SE  Sexual dysfunction.  Anxiety, akathesia,insomnia.  GIT upset.  Headache.  Anorexia.  Wt gain  Somnolence  Dry mouth  Blurred vision  Constipation  Othostatic hypotension  EPS  T DYSKINESIA
  14. 14. Common SE of lithium  Tremors:--- dec dose, indral  GIT UPSET– dec dose  Wt gain---adj wt loss, warn in advance  Cognitive imp--- check thyroid,treat depression  D I--- SWITCH  KIDNEY IMP--- DEC DOSE OR SWITCH  PSORIASIS--- OMEGA 3  ACNE—RETNOIC ,TETRACYCLINE  HYPOTHYROIDISM--- ELTROXIN
  15. 15. THANK YOU

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