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ERIS-Emerging Risk Identification Support System

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Niels Lucas Luijckx from TNO on ERIS-Emerging Risk Identification Support System.

Joint Workshop on Food Risk Assessment Research & Practice
24th November 2017, Wageningen University & Research, Netherlands

Published in: Food
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ERIS-Emerging Risk Identification Support System

  1. 1. ERIS: SUPPORTING THE EARLY DETECTION OF FOOD RISKS AND ISSUES Innovative information analysis and interpretation | Niels Lucas Luijckx
  2. 2. AGINFRA – DEMETER WORKSHOP WAGENINGEN, 24 NOVEMBER 2017 24 November 20172 | ERIS: supporting the early detection of food risks and issues
  3. 3. 3 | ERIS: supporting the early detection of food risks and issues 24 November 2017
  4. 4. TIMING OF SIGNALLING AND WARNING 24 November 20174 | ERIS: supporting the early detection of food risks and issues
  5. 5. WHAT IS THIS ALL ABOUT… Food risks and issues Food Safety: hazards, exposure  risks, health effects Food Integrity: EMA, fraud  Risk or Issue? Early detection Any signal that has the potential of becoming or creating a hazard, risk, fraud opportunity or (thus) issue has to be ‘caught’ Information management is key , but where to start and end It starts with a bit of philosophy…. 5 | ERIS: supporting the early detection of food risks and issues 24 November 2017
  6. 6. FORESIGHT PHILOSOPHY…… 24 November 20176 | ERIS: supporting the early detection of food risks and issues
  7. 7. AND SOME MORE …. 24 November 20177 | ERIS: supporting the early detection of food risks and issues Hindsight Bias + Creeping Determinism  Foresight bias Insight = hindsight + foresight + sense making (understanding reality) What about the unpredictable  “black swan” What about “tipping points”
  8. 8. INFORMATION AND INTERPRETATION Awareness and alertness for early signals is crucial Both in emerging issue identification and in food fraud prevention However…. Interpreting them is a major challenge Uncertainty is a fact even with information and data available Making the right scenario, without over-reacting (making a justified risk management decision) 24 November 20178 | ERIS: supporting the early detection of food risks and issues
  9. 9. A WAY OF THINKING……. 24 November 20179 | ERIS: supporting the early detection of food risks and issues adverse health effect substance food & feed NEW? NEW? NEW? HAZARD
  10. 10. ERIS THINKING Food safety Other domains: Health benefits Consumer opinion Pharma Occupational (chemical) safety Fraud 24 November 201710 | ERIS: supporting the early detection of food risks and issues
  11. 11. ERIS IN A NUTSHELL 24 November 201711 | ERIS: supporting the early detection of food risks and issues System basically has three parts: Ontology: TNO expertise and experience Sources….. Software to make the connection Tailored to user needs Finding multiple relations (matrix search) All results are relevant, but require interpretation
  12. 12. Snippets Keywords, etc Timeline 12 | ERIS: supporting the early detection of food risks and issues 24 November 2017
  13. 13. Ind Health. 2005 Oct;43(4):699-701. 4-oxo-2-hexenal, a mutagen formed by omega-3 fat peroxidation, causes DNA adduct formation in mouse organs. Kasai H, Maekawa M, Kawai K, Hachisuka K, Takahashi Y, Nakamura H, Sawa R, Matsui S, Matsuda T. Abstract To identify mutagens formed in a model reaction of lipid peroxidation, linolenic acid methyl ester and hemin were reacted with dG. As a result, a 4-oxo-2-hexenal-dG adduct (dG*) was identified in the model reaction mixture. The 4-oxo-2-hexenal (4-OHE) showed mutagenic activity in the Salmonella typhimurium strains TA100 and TA104. After 4-OHE was orally administered to mice, dG, 4-OHE-dC- and 4-OHE-5-methyl-dC adducts were detected in esophageal, stomach and intestinal DNA. In the vapor phase released from the methyl linolenate-hemin model system, and in the smoke released during the broiling of fish, 4-OHE was detected by GCMS. The 4-OHE seems to be produced by the auto-oxidation of omega-3 polyunsaturated fatty acids. These results provide a warning to workers dealing with omega-3 fats, who may be exposed to this volatile mutagen. 24 November 201713 | ERIS: supporting the early detection of food risks and issues Product Substance Effect Hyperlink Omega-3 fat 4-oxo-2-hexenal Mutagen 16294926 …. …. …. …… …. …. …. …… Text mining thinking model in linear form
  14. 14. 24 November 2017 IS 4-OHE AN EMERGING RISK? SCIENCE DOMAIN 2005 – 2010 “Kasai & Kawai”: 4-OHE is generated by oxidation omega-3 fatty acids such as in fish oil. 4-OHE is mutagenic in Ames test. 2010, Long et al. The 4-oxo derivative, 4-OHE, has the possibility of being a potent cytotoxin and biological effector as well, and subsequent study needs to be devoted to determining the extent to which 4-OHE, its adducts, or metabolites are found in vivo. PUBLIC DOMAIN 14 | ERIS: supporting the early detection of food risks and issues ?
  15. 15. SOME PROJECTS – TRACK RECORD Demonstration project for EFSA, with continued emerging risk identification Published (EFSA website) Signals management for the US FDA Early Awareness of Risks for a major food company in the US Focus on brand protection and emerging research Several projects and service agreements for companies in food and feed, and branches. 24 November 201715 | ERIS: supporting the early detection of food risks and issues
  16. 16. Ensuring the Integrity of the European food chain WP17: feasibility study information sharing Grant agreement No. 613688
  17. 17. EXPANSIONS Occupational safety and health Immune health and immunotoxicology Pharma -> target safety assessment Early life nutrition Food technology and consumer attitude Plant (waste) substances with health benefit / novel proteins Food fraud / EMA 24 November 201717 | ERIS: supporting the early detection of food risks and issues
  18. 18. 24 November 2017 PUBLIC DOMAIN SCIENCE DOMAIN Melamine in milk powder (China > global 2008) 18 | ERIS: supporting the early detection of food risks and issues 1982 !
  19. 19. 24 November 2017 PUBLIC DOMAIN SCIENCE DOMAIN Melamine in milk powder (China > global 2008) 19 | ERIS: supporting the early detection of food risks and issues 1982 !
  20. 20. 24 November 2017 PUBLIC DOMAIN SCIENCE DOMAIN Melamine in milk powder (China > global 2008) 20 | ERIS: supporting the early detection of food risks and issues 1982 !
  21. 21. 1994, IARC Acrylamide is a probable carcinogen 1997 High acrylamide levels found in non-exposed humans 2000, June Acrylamide in fried rat feed 2002, April 24-26 Sweden, press release: Acrylamide in French fries and other food products Acrylamide formation during heating of food (2002) 24 November 2017 SCIENCE DOMAIN PUBLIC DOMAIN 21 | ERIS: supporting the early detection of food risks and issues
  22. 22. 24 November 2017 Complex food production: “dioxin via feed in cow milk (2004)” potato peeling potato selection consumer Part of feed-dairy chain Part of potato chain dioxin kaolin clay potato peelings potato cleaning potato sorting in clay baths 2004 Already known in 1997 dairy farm feed dairy processing dioxin monitoring 22 | ERIS: supporting the early detection of food risks and issues
  23. 23. SCENARIOS Peoples minds are creative and able to make many associations: TRIGGER THEM Boldly go where …… In this case a scenario is like a funnel, but starting at the smaller end 24 November 201723 | ERIS: supporting the early detection of food risks and issues
  24. 24. TNO EMERGING RISK IDENTIFICATION SUPPORT 24 November 201724 | ERIS: supporting the early detection of food risks and issues CONTACT Niels Lucas Luijckx or Marcel van Zandvoort Niels.lucasluijckx@tno.nl Marcel.vanzandvoort@tno.nl +31 88 86 615 26 www.tno.nl
  25. 25. THANK YOU FOR YOUR ATTENTION

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