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NIH Support of Health Research in California

  1. NIH SUPPORT OF HEALTH RESEARCH IN THE STATE OF CALIFORNIA The Proposed 20% Cuts in NIH Budget May Put Health Research and Jobs at Risk Ahmed Enany President & CEO SoCalBio
  2. C 2017 SoCalBio OVERVIEW  Given the significant role of NIH in supporting health research in US universities, the Trump Administration’s proposed 20% cuts in NIH funding may result in :  Less support for developing life-saving disease treatments.  Reduced funding options for emerging companies.  Fewer bioscience jobs.  In 2016, NIH allocated $24.83 billion -- out of a $32 billion total budget -- in extramural research grants.  With $3.7 billion or 15% of NIH extramural grants, California was the leading recipient of such funding:  5,067 researchers in 416 California organizations were funded.  The bulk of the funding supports basic and applied research at non- profit educational institutions and research hospitals:  UCSF, Stanford U., UCSD, UCLA and Scripps are the top five California organizations attracting $578 million, $427 million, $401 million, $381 million, and $214 million of NIH award funding respectively.  NIH funding in the form of SBIRs and STTRS supports emerging bioscience companies:  In 2016, California attracted one of every five dollars ($176 million out of $812 million) awarded by the NIH in the form of SBIR or STTR grants. 3/22/2017 2
  3. C 2017 SoCalBio IN 2016, NIH ALLOCATED $24.83 BILLION -- OUT OF A $32 BILLION TOTAL BUDGET -- IN EXTRAMURAL RESEARCH GRANTS  These grants supported:  49,013 U.S. research projects.  33,663 principal investigators.  2,382 Universities, research hospitals, emerging small companies engaged in health R&D.  The NIH also allocated $191.72 million to 480 foreign projects.  The majority was submitted by Canadian and European investigators 3/22/2017 3 Institute Awards Funding $Billion NIAID 5,254 $3.07 NCI 6,575 $2.94 NHLBI 4,804 $2.45 NIGMS 5,800 $2.32 NIDDK 3,812 $1.54 NINDS 3,716 $1.35 NIA 2,224 $1.25 NIMH 2,872 $1.19 NICHD 2,265 $1.04 NIDA 1,934 $0.82 NCATS 286 $0.55 2016 Top Funding Source
  4. C 2017 SoCalBio CALIFORNIA GETS MORE NIH FUNDING THAN ANY OTHER STATE 3/22/2017 4 3.69 2.57 2.2 1.57 1.46 1.15 1.09 0.952 0.818 0.734 0 0.5 1 1.5 2 2.5 3 3.5 4 CA MA NY PA MD NC TX WA IL OH 2016NIHFunding $Billion
  5. C 2017 SoCalBio THE BULK OF NIH FUNDING SUPPORTS RESEARCH AT UNIVERSITIES AND RESEARCH HOSPITALS SMALL ALLOCATIONS ARE MADE TO EMERGING COMPANIES IN THE FORM OF SBIRS AND STTRS Funding Mechanism CA Awards CA Funding All Funding CA’s Share RPGs - Non SBIR/STTR 5,203 $2,598,594,751 $17,137,570,924 15% RPGs - SBIR/STTR 381 $176,136,281 $812,043,011 22% Research Centers 240 $385,624,782 $2,642,933,069 15% Other Research- Related 948 $295,184,972 $2,091,322,495 14% R&D Contracts 137 $91,438,716 $1,291,136,757 7% Training - Individual 518 $24,486,544 $147,564,878 17% Training - Institutional 287 $102,836,487 $636,914,717 16% Other 6 $11,724,056 $73,243,401 16% Total 7,720 $3,686,026,589 $24,832,729,252 15% 3/22/2017 5 ResearchAllocations
  6. C 2017 SoCalBio THE LOCATION OF 416 CALIFORNIA ORGANIZATIONS THAT WON $3.7 BILLION IN NIH FUNDING IN 2016 3/22/2017 6 Greater Los Angeles Region 132 Organizations Attracted $1.087 Billion San Diego County 102 Organizations Attracted $850 Million San Francisco Bay Area 160 Organizations Attracted $1.497 Billion Regional Allocations Other CA 22 Organizations Attracted $249.88 Million
  7. C 2017 SoCalBio SAN FRANCISCO BAY AREA ORGANIZATIONS THAT WON NIH GRANTS IN 2016 ORGANIZATION AWARDS FUNDING $Million 1 UCSF 1208 577.57 2 STANFORD UNIV. 944 427.01 3 UC BERKELEY 338 125.90 4 KAISER FOUNDATION 73 62.45 5 SRI INTERNATIONAL 83 51.70 6 J. D. GLADSTONE INST. 53 32.74 7 NORTHERN CA INST. 47 27.09 8 LAWRENC BERKELEY LAB 35 22.01 9 PALO ALTO VET. INST. 32 12.61 10 PUBLIC HEALTH INST. 20 11.28 3/22/2017 7 Top Funding Recipients
  8. C 2017 SoCalBio TOP SAN FRANCISCO BAY AREA INVESTIGATORS, BY THE AMOUNT OF 2016 NIH FUNDING 3/22/2017 8 NAME: GRANDIS, JENNIFER WHITMER, RACHEL HAVLIR, DIANE GREENBERG, HARRY ASHWORTH, ALAN AFFILIATION: UCSF KAISER FOUNDATION UCSF STANFORD UNIVERSITY UCSF # AWARDS: 4 2 3 6 9 FUNDIG $MILLION: $19.82 $13.68 $12.39 $10.99 $8.78 FUNDING FOCUS: HEAD AND NICK CANCER & TRANSLATIONAL SCIENCE COGNITIVE HEALTH AIDS, MALARIA AND ANTIRETROVIRAL THERAPY IMMUNITY AND TRANSLATIONAL RESEARCH EDUCATIOM CANCER CENTER SUPPORT 1 432 5
  9. C 2017 SoCalBio GREATER LOS ANGELES ORGANIZATIONS THAT WON NIH GRANTS IN 2016 3/22/2017 9 ORGANIZATION AWARDS FUNDING $Million 1 UCLA 836 381.047 2 USC 411 212.11 3 UCI 301 111.86 4 CALTECH 134 63.09 5 CEDARS-SINAI 107 47.45 6 CITY OF HOPE 91 42.05 7 RAND CORP. 56 26.08 8 UCR 66 20.35 9 CHILDREN'S HOSPITAL OF LOS ANGELES 41 20.24 10 UCSB 53 18.29 Top Funding Recipients
  10. C 2017 SoCalBio TOP GREATER LOS ANGELES INVESTIGATORS, BY THE AMOUNT OF 2016 NIH FUNDING 3/22/2017 10 NAME: MITSUYASU, RONALD DUBINETT, STEVEN BUCHANAN, THOMAS ROTHERAM- BORUS, MARY JANE STERNBERG, PAUL AFFILIATION: UCLA UCLA USC UCLA CALTECH # AWARDS: 1 2 1 8 4 FUNDING $MILLION: $21.62 $17.51 $9.56 $7.79 $7.23 FUNDING FOCUS: AIDS LUNG CANCER CLINICAL & TRANSLATIO NAL RESEARCH AIDS & DRUG OF ABUSE SYSTEM BIOLOGY OF NEMATODES 1 432 5
  11. C 2017 SoCalBio SAN DIEGO COUNTY ORGANIZATIONS THAT WON NIH GRANTS IN 2016 ORGANIZATION AWARDS FUNDING $Million 1 UCSD 835 $400.87 2 SCRIPPS 288 $213.69 3 SANFORD BURNHAM INST 109 $54.24 4 SALK INSTITUTE 65 $32.59 5 LA JOLLA INST 54 $31.70 6 SAN DIEGO STATE UNIV. 60 $24.60 7 LUDWIG INSTITUTE 22 $9.40 8 VETERANS MEDICAL RESEARCH FDN/SAN DIEGO 17 $7.60 3/22/2017 11 Top Funding Recipients
  12. C 2017 SoCalBio TOP SAN DIEGO COUNTY INVESTIGATORS, BY THE AMOUNT OF 2016 NIH FUNDING NAME: TOPOL, ERIC BURTON, DENNIS FELDMAN, HOWARD FIRESTEIN, GARY ULEVITCH, RICHARD AFFILIATION: SCRIPPS SCRIPPS UCSD UCSD SCRIPPS # AWARDS: 5 4 5 3 1 FUNDIG $MILLION: $42,499,376 $29,321,475 $10,470,025 $9,111,956 $8,033,507 FUNDING FOCUS DIGITAL HEALTH & TRANSLATIONAL SCIENCE AIDS ALZHEIMER’S INFLAMMATION & CLINICAL AND TRANSLATIONAL RESEARCH IMMUNITY & INFLAMMATION 3/22/2017 12 1 432 5
  13. C 2017 SoCalBio DEEP CUTS IN NIH FUNDING PUT HEALTH RESEARCH AND PATIENT WELFARE AT RISK  The NIH controls more than 50 percent of all funding for health research, and 85 percent of all funding for health studies in universities.  The proposed 20% cut in the NIH budget may negatively impact, not just life-science research throughout California and elsewhere, but also patients who are waiting for treatments based on this research.  Numerous studies have documented the direct and indirect benefits of public funding of medical research to develop life-saving drugs and extend life expectancy.  For example, a 2001 National Bureau of Economic Research (NBER) study found that of the 21 drugs with the highest therapeutic impact on society introduced between 1965 and 1992, 14 resulted from key enabling discoveries funded by public research.  According to Dr. Randy Hall, Vice Provost for Research at USC, Public spending on health research have resulted in health improvement and increased life expectancy by 10% during the last five decades in the US.  The social value of increases in longevity and health improvements totaled $95 trillion between 1970 and 2000, according to Research by the University of Chicago and NBER.  Steep cuts in NIH Funding may endanger some of these advances. 3/22/2017 13
  14. C 2017 SoCalBio BIOSCIENCE JOBS MAY ALSO BE AT RISK  NIH funding supports bioscience job creation and industry growth across the country, and California is no different. Cuts in NIH budget may therefore result in:  Fewer job opportunities for college graduates and budding PhDs to start their careers in academia and industry  NIH-dependent research institutions, such as the USC Keck School of Medicine in Los Angeles which receives more than 60 percent of its research funding from competitive NIH grants, are likely to see significant cuts in research and staffing.  USC expects 250 researchers to be laid off, if the proposed Trump cuts take effect.  These cuts also mean less funding options for bioscience startups due to expected cuts in SBIR/STTR grant allocations.  In 2016, 266 California-based emerging bioscience companies were awarded SBIRs/STTRs totaling $176 million.  SBIR funding has served as a life boat enabling such emerging companies to cross the financial “valley of death,” raise capital and grow.  Cuts in such funding may negatively impact startup growth prospects and job creation. 3/22/2017 14
  15. C 2017 SoCalBio On April 4 & 5, 2017, SoCalBio will join other bioscience trade associations and hundreds of biotech executives to meet with legislators in the U.S. Congress during the BIO Legislative Day in Washington, D.C. The mission of this legislative day is to advocate for sustaining, if not increasing, NIH funding and educate law-makers about The Value of Innovation. 3/22/2017 15
  16. C 2017 SoCalBio ABOUT SOCALBIO  Southern California Biomedical Council (SoCalBio) is a nonprofit, member- supported trade association that serves the biotech, medtech, IVD and digital health communities in the six counties that comprise the Greater Los Angeles region (Los Angeles, Orange, Ventura, Santa Barbara, Riverside and San Bernardino).  SoCalBio’s programs help local firms gain access to capital, potential partners and other business services. The Council also promotes technology transfer and workforce training, while informing policy makers and the public at-large about the benefits of the region’s bioscience industry. 3/22/2017 16
  17. 17 Thank You Ahmed A. Enany enany@socalbio.org Southern California Biomedical Council Your Success Is Our Business www.socalbio.org 617 S. Olive St., Ste. 700, Los Angeles, CA 90014 Phn: 800-418-7079 -- Fax: 213-622-7100 -- scbc@socalbio.org
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