Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Amyloid plaques


Published on

Quick Reminder of Amyloid formation and anti-amyloid drugs.

  • Be the first to comment

Amyloid plaques

  1. 1. Amyloid Plaques
  2. 2. PHYSIOLOGICAL PATHWAY: Alpha Secretase
  3. 3. PATHOLOGICAL PATHWAY: Beta Secretase
  4. 4. Beta Secretase Inhibitors• Merck: MK-8931• Lilly: LY450139Severe adverseEffects: cancer
  5. 5. Gamma Secretase Inhibitors• Merck: MK-8931• Eisai: E 2609• Lilly: LY2886721 In clinical trials
  6. 6. Monoclonal Antibodies against Abeta 42 *Solanezumab (Lilly) *Bepaneuzumaub (Pfizer) - failed