Crossing the Valley of Death: The Translational Funding and Management Gap <ul><li>Moderator:   Sharon Begley, Science Edi...
Brain  Developmental Disorders
 
Translating the mGluR Theory into  Novel Therapeutics <ul><li>Scientific Discovery </li></ul><ul><li>Druggable Targets </l...
Seaside Therapeutics Model <ul><li>Venture Philanthropy Seed Funding </li></ul><ul><li>Core Competency in Translational Me...
Basic  Research  Prototype Design or Discovery Preclinical  Development Clinical Development FDA Filing/ Approval & Launch...
Basic  Research [Mostly NIH Funded] Prototype Design or Discovery Preclinical  Development Clinical Development [Mostly La...
The Development Pipeline and Valley of Death Various Solutions Prototype Design or Discovery Preclinical  Development Clin...
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Valley of Death Panel Slides at the Partnering for Cures Conference, December 2, 2009

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A panel at the inaugural Partnering for Cure conference spotlights the translational funding and management gap in biomedical research and development.

Moderator: Sharon Begley, Science Editor, Newsweek

Panelists:
Robi Blumenstein, President, CHDI Management/CHDI Foundation
Randall Carpenter, Co-Founder, President and Chief Executive Officer, Seaside Therapeutics
Dennis Purcell, Managing Partner, Aisling Capital
Amy Comstock Rick, Chief Executive Officer, Parkinson's Action Network
Christian Loucq, PATH Malaria Vaccine Initiative

Published in: Health & Medicine, Business
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Valley of Death Panel Slides at the Partnering for Cures Conference, December 2, 2009

  1. 1. Crossing the Valley of Death: The Translational Funding and Management Gap <ul><li>Moderator: Sharon Begley, Science Editor, Newsweek </li></ul><ul><li>Panelists: </li></ul><ul><li>Robi Blumenstein, President, CHDI Management/CHDI Foundation </li></ul><ul><li>Randall Carpenter, Co-Founder, President and Chief Executive Officer, Seaside Therapeutics </li></ul><ul><li>Dennis Purcell, Managing Partner, Aisling Capital </li></ul><ul><li>Amy Comstock Rick, Chief Executive Officer, Parkinson's Action Network </li></ul><ul><li>Christian Loucq, PATH Malaria Vaccine Initiative </li></ul>
  2. 2. Brain Developmental Disorders
  3. 4. Translating the mGluR Theory into Novel Therapeutics <ul><li>Scientific Discovery </li></ul><ul><li>Druggable Targets </li></ul><ul><li>Efficacy in Model System </li></ul><ul><ul><li>Candidate Drug </li></ul></ul><ul><ul><li>IND-enabling Research </li></ul></ul><ul><li>Human Trials </li></ul>
  4. 5. Seaside Therapeutics Model <ul><li>Venture Philanthropy Seed Funding </li></ul><ul><li>Core Competency in Translational Medicine </li></ul><ul><li>Collaborative Business Model </li></ul><ul><ul><li>Foundations – FRAXA, Autism Speaks, NFXF </li></ul></ul><ul><ul><li>Merck & Co, Inc. – R&D Collaboration </li></ul></ul><ul><ul><li>NIH UO1 Translational Research Cooperative Agreement </li></ul></ul><ul><ul><ul><li>NIMH, NICHD, BPCA, NINDS, FRAXA & Autism Speaks </li></ul></ul></ul><ul><ul><li>Baylor Medical Center – Behavioral Research </li></ul></ul><ul><ul><li>Vanderbilt University – Drug Discovery </li></ul></ul><ul><ul><li>Correlagen Diagnostics – Companion Diagnostic </li></ul></ul>
  5. 6. Basic Research Prototype Design or Discovery Preclinical Development Clinical Development FDA Filing/ Approval & Launch Preparation The Development Pipeline and Valley of Death
  6. 7. Basic Research [Mostly NIH Funded] Prototype Design or Discovery Preclinical Development Clinical Development [Mostly Large Pharma] FDA Filing/ Approval & Launch Preparation The Development Pipeline and Valley of Death [Inconsistent Funding] [Inconsistent Funding]
  7. 8. The Development Pipeline and Valley of Death Various Solutions Prototype Design or Discovery Preclinical Development Clinical Development [Mostly Large Pharma] FDA Filing/ Approval & Launch Preparation Private Foundation Research NIH - SBIR Venture Philanthropy [Inconsistent Funding] [Inconsistent Funding] NIH – CTSA’s TATRC Basic Research [Mostly NIH Funded] TRND

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