Kristin Schneeman Program Director September 12, 2008 “ What You Seed Is What You Get”  Making Faster Cures  the Central O...
Saving lives by saving time <ul><li>Our mission is to identify and implement global solutions to accelerate the pace of  d...
FasterCures’  Blueprint for Change <ul><li>Research Leadership and Innovation </li></ul><ul><ul><li>The Redstone Accelerat...
FasterCures’  Blueprint for Change <ul><li>Research Tools and Resources </li></ul><ul><li>Patients Helping Doctors </li></...
“Entrepreneurs for Cures” What would your business model be if your bottom line were curing a disease?
The High Costs of Business as Usual We’re spending a lot on treating disease: $2.1 trillion on healthcare in 2006 – more t...
A New Central Organizing Principle <ul><li>Our current research infrastructure has led to great advances  in knowledge of ...
The Translation Gap <ul><li>Basic research  is the earliest stage of research, carried out for the advancement of knowledg...
Separating what we  need to do in science and what we need to do in the culture of science to accelerate curing diseases
TRAIN: You Are Not Alone The Redstone Acceleration and Innovation Network Collaborative, mission-driven, results-oriented,...
“ Venture Philanthropy”  -> “Passion Capital” <ul><li>Strategic use of capital </li></ul><ul><li>Building collaborations <...
Nonprofits as “De-Riskers” <ul><li>Developing pre-clinical tools </li></ul><ul><li>Targeting research to support translati...
New Business Models to Accelerate Research <ul><li>More than $66 million in research funding since 2005 </li></ul><ul><li>...
New Business Models to Accelerate Research <ul><li>Funded $126 million in research to date, two-thirds for translational r...
New Business Models to Accelerate Research <ul><li>Has raised $102 million to fund 70 labs worldwide </li></ul><ul><li>4 n...
Instead of  following the money,  lead the money.
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FasterCures Presentation at LifeFest 2008

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FasterCures' Kristin Schneeman provides an overview of the organization's TRAIN initiative at the Life Raft Group's annual meeting.

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FasterCures Presentation at LifeFest 2008

  1. 1. Kristin Schneeman Program Director September 12, 2008 “ What You Seed Is What You Get” Making Faster Cures the Central Organizing Principle of the Research Enterprise
  2. 2. Saving lives by saving time <ul><li>Our mission is to identify and implement global solutions to accelerate the pace of discovery and clinical development of new therapies for the treatment of disease. </li></ul>
  3. 3. FasterCures’ Blueprint for Change <ul><li>Research Leadership and Innovation </li></ul><ul><ul><li>The Redstone Acceleration and Innovation Network (TRAIN): Sharing best practices in funding and conducting innovative research </li></ul></ul><ul><ul><li>Philanthropy Advisory Service: Develop a more transparent information marketplace to help philanthropists make informed investment decisions </li></ul></ul><ul><ul><li>TRAIN-dustrial Relations: Facilitate partnerships between nonprofits and industry to help translate research into therapeutic breakthroughs </li></ul></ul>
  4. 4. FasterCures’ Blueprint for Change <ul><li>Research Tools and Resources </li></ul><ul><li>Patients Helping Doctors </li></ul><ul><li>BioBank Central </li></ul><ul><li>Electronic health records </li></ul><ul><li>Research Environment </li></ul><ul><li>Advocacy for change at the FDA and NIH </li></ul><ul><li>Intellectual property and technology transfer </li></ul><ul><li>HIPAA reform </li></ul>
  5. 5. “Entrepreneurs for Cures” What would your business model be if your bottom line were curing a disease?
  6. 6. The High Costs of Business as Usual We’re spending a lot on treating disease: $2.1 trillion on healthcare in 2006 – more than $7000 per person We’re not spending much on curing disease: And productivity is falling: Sources: CMS, Research!America
  7. 7. A New Central Organizing Principle <ul><li>Our current research infrastructure has led to great advances in knowledge of human health and disease; but it is not a good system for developing therapies for patients </li></ul>studying biology curing diseases
  8. 8. The Translation Gap <ul><li>Basic research is the earliest stage of research, carried out for the advancement of knowledge, without necessarily any regard to its application to practical problems. </li></ul>Translational research is the process of applying ideas, insights, and discoveries generated through basic scientific inquiry to the treatment and prevention of human disease – the critical bridge between basic research and clinical research. Clinical research is research in human subjects aiming toward approved treatments for patients.
  9. 9. Separating what we need to do in science and what we need to do in the culture of science to accelerate curing diseases
  10. 10. TRAIN: You Are Not Alone The Redstone Acceleration and Innovation Network Collaborative, mission-driven, results-oriented, and strategic in their use of capital, these groups are motivated solely by moving promising therapies from the laboratory bench to the patient’s bedside as rapidly as possible – even those that do not directly fund therapy development.
  11. 11. “ Venture Philanthropy” -> “Passion Capital” <ul><li>Strategic use of capital </li></ul><ul><li>Building collaborations </li></ul><ul><li>Streamlining the grantmaking process </li></ul><ul><li>Sharing information </li></ul>“… patient groups with an entrepreneurial bent have become the drug industry’s new power brokers.” - Forbes , 9/15/08
  12. 12. Nonprofits as “De-Riskers” <ul><li>Developing pre-clinical tools </li></ul><ul><li>Targeting research to support translation </li></ul><ul><li>Funding mechanisms that bring in industry </li></ul><ul><li>Managing academic science </li></ul><ul><li>Access to patient community </li></ul><ul><li>New indications for existing drugs </li></ul><ul><li>High-throughput screening of promising compounds </li></ul><ul><li>Access to scientific expertise </li></ul><ul><li>Advocating with FDA </li></ul>
  13. 13. New Business Models to Accelerate Research <ul><li>More than $66 million in research funding since 2005 </li></ul><ul><li>Actively supports more than 30 new treatments in development – 4 FDA-approved </li></ul><ul><li>Partners include Vertex Pharmaceuticals, Parion Sciences, PTC Therapeutics, Inspire Pharmaceuticals, Gilead Sciences, Altus Pharmaceuticals </li></ul>Research Preclinical Phase 1 Phase 2 Phase 3 To Patients
  14. 14. New Business Models to Accelerate Research <ul><li>Funded $126 million in research to date, two-thirds for translational research </li></ul><ul><li>Funded testing of over 100 therapeutic targets for Parkinson’s Disease </li></ul><ul><li>Partnership with Elan Corp. gives Elan first look at promising projects </li></ul>
  15. 15. New Business Models to Accelerate Research <ul><li>Has raised $102 million to fund 70 labs worldwide </li></ul><ul><li>4 new treatments approved in 4 years </li></ul><ul><li>10 clinical trials facilitated by MMRF’s Research Consortium </li></ul><ul><li>30 MMRF-funded compounds now in preclinical studies and clinical trials </li></ul>
  16. 16. Instead of following the money, lead the money.

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