SlideShare a Scribd company logo
Steroid hormon reseptrleri, transkripsiyon faktrleridir. Steroid reseptr ailesinin bir yesi olarak
strojen hormon reseptr (ER), strojene (E2) balandktan sonra, hcresel proliferasyon iin kritik olan
strojene duyarl genlerin ekspresyonunu modle etmek iin strojene duyarl elementler (ERE'ler) ad
verilen spesifik DNA dizileriyle etkileime girer. Yalnzca ER ifade eden ancak dier steroid hormon
reseptrlerini ifade etmeyen bir hcre dizisi vardr. Ancak bu ER, E2 yerine androjen hormonuna (An)
balanan mutant bir reseptrdr. Bu hcre hattnda, E2'ye yant olarak ER'nin oalmay arttrd ynndeki
beklentinizin aksine, bir tedavinin oalmann basklanmasna yol atn gzlemlersiniz. An'n hcre oalmasn
neden bastrdn dnyorsunuz?

More Related Content

More from abibagschennai

Let X1Xn be a random sample from the pdf fxex where.pdf
Let X1Xn be a random sample from the pdf fxex where.pdfLet X1Xn be a random sample from the pdf fxex where.pdf
Let X1Xn be a random sample from the pdf fxex where.pdf
abibagschennai
 
Researchers believe that IQ scores may have less to do with .pdf
Researchers believe that IQ scores may have less to do with .pdfResearchers believe that IQ scores may have less to do with .pdf
Researchers believe that IQ scores may have less to do with .pdf
abibagschennai
 
Por qu muestran pinginos y moscas de la fruta Quieren d.pdf
Por qu muestran pinginos y moscas de la fruta  Quieren d.pdfPor qu muestran pinginos y moscas de la fruta  Quieren d.pdf
Por qu muestran pinginos y moscas de la fruta Quieren d.pdf
abibagschennai
 
quickly Fin 1 Fin 4 g33 Nan at the figures Ha2 Provies rip.pdf
quickly  Fin 1 Fin 4 g33 Nan at the figures Ha2 Provies rip.pdfquickly  Fin 1 Fin 4 g33 Nan at the figures Ha2 Provies rip.pdf
quickly Fin 1 Fin 4 g33 Nan at the figures Ha2 Provies rip.pdf
abibagschennai
 
publicationDatatxt.pdf
publicationDatatxt.pdfpublicationDatatxt.pdf
publicationDatatxt.pdf
abibagschennai
 
Programming Assignment 4 Chapter 5 Write compile and test.pdf
Programming Assignment 4 Chapter 5 Write compile and test.pdfProgramming Assignment 4 Chapter 5 Write compile and test.pdf
Programming Assignment 4 Chapter 5 Write compile and test.pdf
abibagschennai
 
Oliver is saving for a car At the start of the first month .pdf
Oliver is saving for a car At the start of the first month .pdfOliver is saving for a car At the start of the first month .pdf
Oliver is saving for a car At the start of the first month .pdf
abibagschennai
 
PART 1 What two languages form the basis for medical termi.pdf
PART 1  What two languages form the basis for medical termi.pdfPART 1  What two languages form the basis for medical termi.pdf
PART 1 What two languages form the basis for medical termi.pdf
abibagschennai
 
Over the last decades the rapid spread of digital devices i.pdf
Over the last decades the rapid spread of digital devices i.pdfOver the last decades the rapid spread of digital devices i.pdf
Over the last decades the rapid spread of digital devices i.pdf
abibagschennai
 
Marvin the fly starts at 00 Each step Marvin moves one .pdf
Marvin the fly starts at 00 Each step Marvin moves one .pdfMarvin the fly starts at 00 Each step Marvin moves one .pdf
Marvin the fly starts at 00 Each step Marvin moves one .pdf
abibagschennai
 
If a message of length n bits is sent across a binary symmet.pdf
If a message of length n bits is sent across a binary symmet.pdfIf a message of length n bits is sent across a binary symmet.pdf
If a message of length n bits is sent across a binary symmet.pdf
abibagschennai
 
Look at the following structure declaration struct Containe.pdf
Look at the following structure declaration struct Containe.pdfLook at the following structure declaration struct Containe.pdf
Look at the following structure declaration struct Containe.pdf
abibagschennai
 
kltr ve eitlilik Doru yanl 1 Bilgi herhangi bir klt.pdf
kltr ve eitlilik  Doru yanl  1 Bilgi herhangi bir klt.pdfkltr ve eitlilik  Doru yanl  1 Bilgi herhangi bir klt.pdf
kltr ve eitlilik Doru yanl 1 Bilgi herhangi bir klt.pdf
abibagschennai
 
La distancia fsica entre las partes y la formalidad del ent.pdf
La distancia fsica entre las partes y la formalidad del ent.pdfLa distancia fsica entre las partes y la formalidad del ent.pdf
La distancia fsica entre las partes y la formalidad del ent.pdf
abibagschennai
 
Javier asked his brothers Mario and Luis to keep the books a.pdf
Javier asked his brothers Mario and Luis to keep the books a.pdfJavier asked his brothers Mario and Luis to keep the books a.pdf
Javier asked his brothers Mario and Luis to keep the books a.pdf
abibagschennai
 
In a small community in Quebec public health professionals .pdf
In a small community in Quebec public health professionals .pdfIn a small community in Quebec public health professionals .pdf
In a small community in Quebec public health professionals .pdf
abibagschennai
 
If the probability density of a random variable is given by .pdf
If the probability density of a random variable is given by .pdfIf the probability density of a random variable is given by .pdf
If the probability density of a random variable is given by .pdf
abibagschennai
 
Exercise 9 Lampetra specimen Erook Lamprey Lampreys are .pdf
Exercise 9 Lampetra specimen Erook Lamprey Lampreys are .pdfExercise 9 Lampetra specimen Erook Lamprey Lampreys are .pdf
Exercise 9 Lampetra specimen Erook Lamprey Lampreys are .pdf
abibagschennai
 
Here are the source code for mapping part Mappingh pragma .pdf
Here are the source code for mapping part Mappingh pragma .pdfHere are the source code for mapping part Mappingh pragma .pdf
Here are the source code for mapping part Mappingh pragma .pdf
abibagschennai
 
Help Please Im so confused lm formula zdiffzlag1+1+zdif.pdf
Help Please Im so confused lm formula zdiffzlag1+1+zdif.pdfHelp Please Im so confused lm formula zdiffzlag1+1+zdif.pdf
Help Please Im so confused lm formula zdiffzlag1+1+zdif.pdf
abibagschennai
 

More from abibagschennai (20)

Let X1Xn be a random sample from the pdf fxex where.pdf
Let X1Xn be a random sample from the pdf fxex where.pdfLet X1Xn be a random sample from the pdf fxex where.pdf
Let X1Xn be a random sample from the pdf fxex where.pdf
 
Researchers believe that IQ scores may have less to do with .pdf
Researchers believe that IQ scores may have less to do with .pdfResearchers believe that IQ scores may have less to do with .pdf
Researchers believe that IQ scores may have less to do with .pdf
 
Por qu muestran pinginos y moscas de la fruta Quieren d.pdf
Por qu muestran pinginos y moscas de la fruta  Quieren d.pdfPor qu muestran pinginos y moscas de la fruta  Quieren d.pdf
Por qu muestran pinginos y moscas de la fruta Quieren d.pdf
 
quickly Fin 1 Fin 4 g33 Nan at the figures Ha2 Provies rip.pdf
quickly  Fin 1 Fin 4 g33 Nan at the figures Ha2 Provies rip.pdfquickly  Fin 1 Fin 4 g33 Nan at the figures Ha2 Provies rip.pdf
quickly Fin 1 Fin 4 g33 Nan at the figures Ha2 Provies rip.pdf
 
publicationDatatxt.pdf
publicationDatatxt.pdfpublicationDatatxt.pdf
publicationDatatxt.pdf
 
Programming Assignment 4 Chapter 5 Write compile and test.pdf
Programming Assignment 4 Chapter 5 Write compile and test.pdfProgramming Assignment 4 Chapter 5 Write compile and test.pdf
Programming Assignment 4 Chapter 5 Write compile and test.pdf
 
Oliver is saving for a car At the start of the first month .pdf
Oliver is saving for a car At the start of the first month .pdfOliver is saving for a car At the start of the first month .pdf
Oliver is saving for a car At the start of the first month .pdf
 
PART 1 What two languages form the basis for medical termi.pdf
PART 1  What two languages form the basis for medical termi.pdfPART 1  What two languages form the basis for medical termi.pdf
PART 1 What two languages form the basis for medical termi.pdf
 
Over the last decades the rapid spread of digital devices i.pdf
Over the last decades the rapid spread of digital devices i.pdfOver the last decades the rapid spread of digital devices i.pdf
Over the last decades the rapid spread of digital devices i.pdf
 
Marvin the fly starts at 00 Each step Marvin moves one .pdf
Marvin the fly starts at 00 Each step Marvin moves one .pdfMarvin the fly starts at 00 Each step Marvin moves one .pdf
Marvin the fly starts at 00 Each step Marvin moves one .pdf
 
If a message of length n bits is sent across a binary symmet.pdf
If a message of length n bits is sent across a binary symmet.pdfIf a message of length n bits is sent across a binary symmet.pdf
If a message of length n bits is sent across a binary symmet.pdf
 
Look at the following structure declaration struct Containe.pdf
Look at the following structure declaration struct Containe.pdfLook at the following structure declaration struct Containe.pdf
Look at the following structure declaration struct Containe.pdf
 
kltr ve eitlilik Doru yanl 1 Bilgi herhangi bir klt.pdf
kltr ve eitlilik  Doru yanl  1 Bilgi herhangi bir klt.pdfkltr ve eitlilik  Doru yanl  1 Bilgi herhangi bir klt.pdf
kltr ve eitlilik Doru yanl 1 Bilgi herhangi bir klt.pdf
 
La distancia fsica entre las partes y la formalidad del ent.pdf
La distancia fsica entre las partes y la formalidad del ent.pdfLa distancia fsica entre las partes y la formalidad del ent.pdf
La distancia fsica entre las partes y la formalidad del ent.pdf
 
Javier asked his brothers Mario and Luis to keep the books a.pdf
Javier asked his brothers Mario and Luis to keep the books a.pdfJavier asked his brothers Mario and Luis to keep the books a.pdf
Javier asked his brothers Mario and Luis to keep the books a.pdf
 
In a small community in Quebec public health professionals .pdf
In a small community in Quebec public health professionals .pdfIn a small community in Quebec public health professionals .pdf
In a small community in Quebec public health professionals .pdf
 
If the probability density of a random variable is given by .pdf
If the probability density of a random variable is given by .pdfIf the probability density of a random variable is given by .pdf
If the probability density of a random variable is given by .pdf
 
Exercise 9 Lampetra specimen Erook Lamprey Lampreys are .pdf
Exercise 9 Lampetra specimen Erook Lamprey Lampreys are .pdfExercise 9 Lampetra specimen Erook Lamprey Lampreys are .pdf
Exercise 9 Lampetra specimen Erook Lamprey Lampreys are .pdf
 
Here are the source code for mapping part Mappingh pragma .pdf
Here are the source code for mapping part Mappingh pragma .pdfHere are the source code for mapping part Mappingh pragma .pdf
Here are the source code for mapping part Mappingh pragma .pdf
 
Help Please Im so confused lm formula zdiffzlag1+1+zdif.pdf
Help Please Im so confused lm formula zdiffzlag1+1+zdif.pdfHelp Please Im so confused lm formula zdiffzlag1+1+zdif.pdf
Help Please Im so confused lm formula zdiffzlag1+1+zdif.pdf
 

Steroid hormon reseptrleri transkripsiyon faktrleridir S.pdf

  • 1. Steroid hormon reseptrleri, transkripsiyon faktrleridir. Steroid reseptr ailesinin bir yesi olarak strojen hormon reseptr (ER), strojene (E2) balandktan sonra, hcresel proliferasyon iin kritik olan strojene duyarl genlerin ekspresyonunu modle etmek iin strojene duyarl elementler (ERE'ler) ad verilen spesifik DNA dizileriyle etkileime girer. Yalnzca ER ifade eden ancak dier steroid hormon reseptrlerini ifade etmeyen bir hcre dizisi vardr. Ancak bu ER, E2 yerine androjen hormonuna (An) balanan mutant bir reseptrdr. Bu hcre hattnda, E2'ye yant olarak ER'nin oalmay arttrd ynndeki beklentinizin aksine, bir tedavinin oalmann basklanmasna yol atn gzlemlersiniz. An'n hcre oalmasn neden bastrdn dnyorsunuz?