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Surgical disorders in Newborn

       Dr. Abhijeet Deshmukh
• Fetal surgical disorders:
 Polyhydramnios:
 - 1:1000 births
 Causes:
 1. GI obstruction
 2. Abdominal wall defects
    Omphalocele, gastroschisis, diaphragmatic
 hernia, tight nuchal cord
• Oligohydramnios:
  Renal dysgenesis/ agenesis
• Meconium peritonitis:
  Antenatal perforation of GIT
  Intestinal obstruction
• Fetal ascites:
  Urinary tract anomalies – Posterior
  urethral valve, thoracic duct obstruction,
  hepatic/portal vein obstruction
• Postnatal surgical disorders:
 A. Respiratory distress:
 - Diaphragmatic hernia
 - Coanal atresia
 - Laryngeal clefts
 - Tracheal agenesis
 - Oesophageal atresia
 - Congenital lobar emphysema
 - Cystic adenomatoid malformation of lung
B.   Scaphoid abdomen
-    Diaphragmatic hernia
-    EA without TEF
C.   Excessive mucus & salivation
-    EA with/ without TEF
D.   Abdominal distention
-    Pneumoperitonium
     Causes are : NEC, bowel wall ischemia,
     instrumentation, TEF
E. Vomiting:
1. Bilious emesis :
    Can be a life threatening emergency
    20% require immediate surgical
    intervention
Causes:
- Malrotation with/ without volvulus
- Duodenal/jejunal/ileal/colonic atresias
-   Annular pancreas
-   Hirschprung disease
-   Preduodenal portal veins
-   Peritoneal bands
-   Persistent omphalomesenteric duct
-   Duodenal duplication
-   Decreased motility of intestine
2. Nonbilious emesis:
- Excessive feeding
- Milk intolerance
- Sepsis
- Lesions above ampulla of Veter
    > Pyloric stenosis
    > Upper duodenal stenosis
    > Annular pancreas
F.   Failure to develop transient stools:
-    volvulus
-    Malrotation
G.   Hematemesis/ Hematochezia:
-    Nonsurgical conditions :
     > Milk intolerance
     > Instrumentation
     > Swallowed maternal blood
-   Surgical conditions:
    > NEC (most frequent in premature infants)
    > Gastric/duodenal ulcers (stress/steroids)
    > Coagulation disorders (DIC/ Vit K def.)
    > Volvulus
    > GI obstructions
    > Intussuception
    > Polyps/ hemangiomas
> Meckel diverticulum
    > Duplication of small intestine
H. Abdominal mass :
- GU abnormalities
- Hepatosplenomegaly
- Tumors
I . Birth trauma:
- Fractured clavicle
- IC haemorrhages
- Spinal cord transection
Lesions causing Respiratory distress
  A. EA and TEF:
  - 85% association
  - Absence of stomach bubble
• Postnatal presentation
  - Excessive salivation & vomiting soon after
     birth
  - Scaphoid abdomen
• Diagnosis:
  - Inability to pass NG tube
  - Confirmed by X ray : coiled catheter ,
     distended upper oesophagus after pushing
     air.
• Other associated anomalies:
  - Vertebral defects
  - Imperforate anus
  - Cardiac defects
  - Renal dysplasia
  - Limb anomalies
• Management:
  - Oro-nasal suction
  - Head end elevation -45 degree
  - Immediate gastrostomy tube placement.
Tracheo Esophageal Fistula (TEF)
• Incidence: 1:4000 live births

• M > F (25:3)

• 10-40% are preterm

• Antenatal history: polyhydramnios (60%)

• Etiology: failure in mesenchymal separation
          of upper foregut
• Clinical Presentation
 choking on 1st feed
 coughing
 cyanosis
 excessive salivation
 aspiration pneumonia
• Diagnosis

  • Inability to pass a suction catheter into the
    stomach

  • CXR: Coiled orogastric tube in the cervical
    pouch, air in the stomach and intestine
Esophageal Atresia   Tracheoesophageal Fistula
• 5 Types (Gross and Vogt)




7.7%      4.2%     0.8%      86%   0.7%   0.7%
• 35-65% have associated anomalies
  V Vertebral anomalies or VSD
  A Anorectal malformation
  C Cardiac anomalies (common)
  T TEF
  E Esophageal atresia
  R Renal abnormalities
  L Limb/radial malformation
Laboratory studies
     CBC
     Electrolytes
     Glucose
     Calcium
     ABGs
- NPO
- IVF & Antibiotics
- Ensure availability of blood in the OT
- Optimize volume status and metabolic state
- Intubation preferably in the operating room under
  controlled situation
- Echo
• Surgical repair
  • Ligation of fistula
  • Esophageal repair
  – Chest tube placement and closure of
    thoracic cavity
Diaphragmatic Hernia
-   Most difficult of all neonatal emergencies
-   Most common site is left hemithorax.
-   Incidence 1 : 4000 live births
-   Associated with trisomies 13 & 18, 45 XO
    Goldenhar syndrome,
    Backwith- Wiedmann synd.
    Pierre robin synd.
    Goltz-Gorlin synd.
    Rubella synd.
Classification
• Absent diaphragm : rare
• Diaphragmatic hernia
  80% posterolateral L >R
       (Bochdalek)
  2% anterior (Morgagni)
  15 - 20% paraesophageal
• Eventration (15 - 20%)
• Symptoms :
  - Cyanosis at birth
  - Respiratory distress
  - Scaphoid abdomen
  - Decreased / absent breath sounds on
     hernial side
  - Shift of cardiac sounds opposite to the
     hernia
• Diagnosis:
  1. Antenatal diagnosis –
  - Often undetected as it occurs mostly after
      16 wks.
  - Presence of liver in the thorax asso with
      increased severity & poor prognosis
2. Postnatal diagnosis:

X ray : cardiothymic shift

- loops of bowel in the chest

- mediastinal shift

- absent lung markings
•       Treatment:
    -   Immediate intubation
    -   Bag & mask is contraindicated
    -   immediate NG tube insertion & continuous
        suction.
    -   Low pressure ventilation - to avoid damage
        to contra lateral lung.
    -   Surgical repair with reduction of intestine into
        abdominal cavity.
Extracorporeal Membrane Oxygenation
  (ECMO)
• Use: controversial
• Allows the lungs to develop & restructure
• Expensive
Criteria for ECMO
• Gestational age ≥ 34 wks
• Weight ≥ 2000 grams
  Predicted mortality ≥ 80%
• Associated anomalies (20-50%) :
     cardiovascular     13 - 23%
     CNS                28%
     gastrointestinal   20%
     genitourinary      15%
Anorectal malformations
Frequency

• 1 : 5000 live births
TYPES
• HIGH TYPE
• LOW TYPE
Clinical Findings
• High type :
   – A flat perineum & lack of a midline gluteal fold
   – Absence of an anal dimple
• Low type :
   – the presence of meconium at the perineum,
   – A bucket-handle malformation
   – Anal membrane (through which meconium is visible).
INVERTOGRAM
  16-24 hours
A flat perineum
A flat perineum-GIRL
Perineal fistula
bucket-handle malformation
Associated malformations

Genitourinary :
 - Absent, dysplastic, or horseshoe
   kidneys
 - Vesicoureteral reflux
 - Hydronephrosis
 - Hypospadias
 - Bifid scrotum
Skeletal System :
•   Partial or complete lumbosacral agenesis
•   Hemivertebrae
•   Agenesis of thoracic vertebrae
•   Scoliosis
•   Hemisacrum or scimitar sacrum
•   Asymmetric sacrum
•   Posterior protruding sacrum
•   Agenesis of the coccyx
Spinal anomalies :
•   Tethered cord
•   Dural sac stenosis
•   Narrow spinal canal
•   Myelomeningocele, meningocele
•   Intraspinal teratoma
•   Neurogenic bladder
Gastrointestinal and Cardiovascular
 Systems
• VATER and VACTERL associations:
  – Esophageal atresia
  – Duodenal atresia
  – Ventricular or atrioseptal defects
  – Tetrology of Fallot
  – Hirschsprung's disease
Surgical therapy

• Colostomy
• Definitive repair
Colostomy Newborn boys

•   Rectobulbar urethral fistula
•   Rectoprostatic urethral fistula
•   Rectovesical fistula
•   Imperforate anus without fistula
•   Rectal atresia
Newborn girls
                   Colostomy -
•   Rectovestibular fistula
•   Imperforate anus without fistula
•   Persistent cloaca
•   Rectal atresia
•   Rectovaginal fistula
COLOSTOMY
Definitive repair

• Anoplasty : Indications
  – Rectoperineal fistula - girls & boys
  – Covered anus
  – Bucket-handle malformation
• posterior sagittal ARP
• Laprotomy
PSARP
Outcome after surgery
• Altered bowel habits in most of the cases
• 50% - few episodes of accidental soilage
• Few of them require major adjustments in lifestyle
  secondary to fecal incontinence, chronic
  constipation, and odor.
Necrotizing Enterocolitis
(NEC)
• Life-threatening intestinal inflammation or injury
• Caused by bacterial invasion of previously injured
  or ischemic bowel wall
• Incidence: 5 -10% in infants <1500g birth weight
• Mortality rate: 10 - 30%
• Single most important factor
   PREMATURITY
• Can occur in:
     LBW infants
     Full term infants
     Fed and unfed infants
• Other factors
  - ischemia
  - bacterial infection
  - GI endotoxemia
  - enteral feeding
  - use of hyperosmolar formula
  - congenital heart disease
  - umbilical arterial catheterization
  - exchange transfusion
Early signs
  -   ↑ gastric residuals with feedings
  -   temperature instability
  -   poor feeding
  -   bilious vomiting
  -   lethargy
  -   mucoid or bloody stool
  -   apnea and bradycardia
• Late Signs
     • Hemodynamic instability
     • Anemia
     • Thrombocytopenia
     • Coagulopathy, DIC
     • Prerenal azotemia
     • Metabolic acidosis
Physical Exam
      distended and tender abdomen
Labs:
      CBC
      electrolytes and glucose
      platelets and coagulation profile
      DIC profile
      ABG
Abdominal X-ray
• signs of bowel obstruction
• Ileus with edematous bowel
• Pneumatosis intestinalis or
  intramural air (arrow)
• Air in portal vein
• pneumoperitoneum
Medical Management
  • No enteral feedings for 10-14 days
  • NGT on intermittent suction
  • Hydration and correction of electrolytes
  • Ventilatory support
  • Antibiotics
  • Blood and platelet transfusion if needed
• Surgical Indications
Absolute Indications
1) bowel perforation
2) intestinal gangrene
• Relative Indications
   – metabolic acidosis
   – respiratory failure
   – oliguria, hypovolemia
   – thrombocytopenia
   – leucopenia, leukocytosis
   – air in the portal vein
   – bowel wall edema
   – persistent dilated bowel loops
• Non-Surgical Indications

  severe GI hemorrhage

  abdominal tenderness

  intestinal obstruction

  gasless abdomen with ascites
Thank You!

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Surgical disorders in newborns: Diagnosis and management

  • 1. Surgical disorders in Newborn Dr. Abhijeet Deshmukh
  • 2. • Fetal surgical disorders: Polyhydramnios: - 1:1000 births Causes: 1. GI obstruction 2. Abdominal wall defects Omphalocele, gastroschisis, diaphragmatic hernia, tight nuchal cord
  • 3. • Oligohydramnios: Renal dysgenesis/ agenesis • Meconium peritonitis: Antenatal perforation of GIT Intestinal obstruction
  • 4. • Fetal ascites: Urinary tract anomalies – Posterior urethral valve, thoracic duct obstruction, hepatic/portal vein obstruction
  • 5. • Postnatal surgical disorders: A. Respiratory distress: - Diaphragmatic hernia - Coanal atresia - Laryngeal clefts - Tracheal agenesis - Oesophageal atresia - Congenital lobar emphysema - Cystic adenomatoid malformation of lung
  • 6. B. Scaphoid abdomen - Diaphragmatic hernia - EA without TEF C. Excessive mucus & salivation - EA with/ without TEF D. Abdominal distention - Pneumoperitonium Causes are : NEC, bowel wall ischemia, instrumentation, TEF
  • 7. E. Vomiting: 1. Bilious emesis : Can be a life threatening emergency 20% require immediate surgical intervention Causes: - Malrotation with/ without volvulus - Duodenal/jejunal/ileal/colonic atresias
  • 8. - Annular pancreas - Hirschprung disease - Preduodenal portal veins - Peritoneal bands - Persistent omphalomesenteric duct - Duodenal duplication - Decreased motility of intestine
  • 9. 2. Nonbilious emesis: - Excessive feeding - Milk intolerance - Sepsis - Lesions above ampulla of Veter > Pyloric stenosis > Upper duodenal stenosis > Annular pancreas
  • 10. F. Failure to develop transient stools: - volvulus - Malrotation G. Hematemesis/ Hematochezia: - Nonsurgical conditions : > Milk intolerance > Instrumentation > Swallowed maternal blood
  • 11. - Surgical conditions: > NEC (most frequent in premature infants) > Gastric/duodenal ulcers (stress/steroids) > Coagulation disorders (DIC/ Vit K def.) > Volvulus > GI obstructions > Intussuception > Polyps/ hemangiomas
  • 12. > Meckel diverticulum > Duplication of small intestine H. Abdominal mass : - GU abnormalities - Hepatosplenomegaly - Tumors I . Birth trauma: - Fractured clavicle - IC haemorrhages - Spinal cord transection
  • 13. Lesions causing Respiratory distress A. EA and TEF: - 85% association - Absence of stomach bubble • Postnatal presentation - Excessive salivation & vomiting soon after birth - Scaphoid abdomen
  • 14. • Diagnosis: - Inability to pass NG tube - Confirmed by X ray : coiled catheter , distended upper oesophagus after pushing air. • Other associated anomalies: - Vertebral defects - Imperforate anus - Cardiac defects - Renal dysplasia - Limb anomalies
  • 15. • Management: - Oro-nasal suction - Head end elevation -45 degree - Immediate gastrostomy tube placement.
  • 17. • Incidence: 1:4000 live births • M > F (25:3) • 10-40% are preterm • Antenatal history: polyhydramnios (60%) • Etiology: failure in mesenchymal separation of upper foregut
  • 18. • Clinical Presentation choking on 1st feed coughing cyanosis excessive salivation aspiration pneumonia
  • 19. • Diagnosis • Inability to pass a suction catheter into the stomach • CXR: Coiled orogastric tube in the cervical pouch, air in the stomach and intestine
  • 20. Esophageal Atresia Tracheoesophageal Fistula
  • 21. • 5 Types (Gross and Vogt) 7.7% 4.2% 0.8% 86% 0.7% 0.7%
  • 22. • 35-65% have associated anomalies V Vertebral anomalies or VSD A Anorectal malformation C Cardiac anomalies (common) T TEF E Esophageal atresia R Renal abnormalities L Limb/radial malformation
  • 23. Laboratory studies CBC Electrolytes Glucose Calcium ABGs
  • 24. - NPO - IVF & Antibiotics - Ensure availability of blood in the OT - Optimize volume status and metabolic state - Intubation preferably in the operating room under controlled situation - Echo
  • 25. • Surgical repair • Ligation of fistula • Esophageal repair – Chest tube placement and closure of thoracic cavity
  • 27. - Most difficult of all neonatal emergencies - Most common site is left hemithorax. - Incidence 1 : 4000 live births - Associated with trisomies 13 & 18, 45 XO Goldenhar syndrome, Backwith- Wiedmann synd. Pierre robin synd. Goltz-Gorlin synd. Rubella synd.
  • 28. Classification • Absent diaphragm : rare • Diaphragmatic hernia 80% posterolateral L >R (Bochdalek) 2% anterior (Morgagni) 15 - 20% paraesophageal • Eventration (15 - 20%)
  • 29. • Symptoms : - Cyanosis at birth - Respiratory distress - Scaphoid abdomen - Decreased / absent breath sounds on hernial side - Shift of cardiac sounds opposite to the hernia
  • 30. • Diagnosis: 1. Antenatal diagnosis – - Often undetected as it occurs mostly after 16 wks. - Presence of liver in the thorax asso with increased severity & poor prognosis
  • 31. 2. Postnatal diagnosis: X ray : cardiothymic shift - loops of bowel in the chest - mediastinal shift - absent lung markings
  • 32. Treatment: - Immediate intubation - Bag & mask is contraindicated - immediate NG tube insertion & continuous suction. - Low pressure ventilation - to avoid damage to contra lateral lung. - Surgical repair with reduction of intestine into abdominal cavity.
  • 33. Extracorporeal Membrane Oxygenation (ECMO) • Use: controversial • Allows the lungs to develop & restructure • Expensive
  • 34. Criteria for ECMO • Gestational age ≥ 34 wks • Weight ≥ 2000 grams Predicted mortality ≥ 80%
  • 35. • Associated anomalies (20-50%) : cardiovascular 13 - 23% CNS 28% gastrointestinal 20% genitourinary 15%
  • 37. Frequency • 1 : 5000 live births
  • 39. Clinical Findings • High type : – A flat perineum & lack of a midline gluteal fold – Absence of an anal dimple • Low type : – the presence of meconium at the perineum, – A bucket-handle malformation – Anal membrane (through which meconium is visible).
  • 45. Associated malformations Genitourinary : - Absent, dysplastic, or horseshoe kidneys - Vesicoureteral reflux - Hydronephrosis - Hypospadias - Bifid scrotum
  • 46. Skeletal System : • Partial or complete lumbosacral agenesis • Hemivertebrae • Agenesis of thoracic vertebrae • Scoliosis • Hemisacrum or scimitar sacrum • Asymmetric sacrum • Posterior protruding sacrum • Agenesis of the coccyx
  • 47. Spinal anomalies : • Tethered cord • Dural sac stenosis • Narrow spinal canal • Myelomeningocele, meningocele • Intraspinal teratoma • Neurogenic bladder
  • 48. Gastrointestinal and Cardiovascular Systems • VATER and VACTERL associations: – Esophageal atresia – Duodenal atresia – Ventricular or atrioseptal defects – Tetrology of Fallot – Hirschsprung's disease
  • 50. Colostomy Newborn boys • Rectobulbar urethral fistula • Rectoprostatic urethral fistula • Rectovesical fistula • Imperforate anus without fistula • Rectal atresia
  • 51. Newborn girls Colostomy - • Rectovestibular fistula • Imperforate anus without fistula • Persistent cloaca • Rectal atresia • Rectovaginal fistula
  • 52.
  • 53.
  • 55. Definitive repair • Anoplasty : Indications – Rectoperineal fistula - girls & boys – Covered anus – Bucket-handle malformation
  • 56. • posterior sagittal ARP • Laprotomy
  • 57. PSARP
  • 58. Outcome after surgery • Altered bowel habits in most of the cases • 50% - few episodes of accidental soilage • Few of them require major adjustments in lifestyle secondary to fecal incontinence, chronic constipation, and odor.
  • 60. • Life-threatening intestinal inflammation or injury • Caused by bacterial invasion of previously injured or ischemic bowel wall • Incidence: 5 -10% in infants <1500g birth weight • Mortality rate: 10 - 30%
  • 61. • Single most important factor PREMATURITY • Can occur in: LBW infants Full term infants Fed and unfed infants
  • 62. • Other factors - ischemia - bacterial infection - GI endotoxemia - enteral feeding - use of hyperosmolar formula - congenital heart disease - umbilical arterial catheterization - exchange transfusion
  • 63. Early signs - ↑ gastric residuals with feedings - temperature instability - poor feeding - bilious vomiting - lethargy - mucoid or bloody stool - apnea and bradycardia
  • 64. • Late Signs • Hemodynamic instability • Anemia • Thrombocytopenia • Coagulopathy, DIC • Prerenal azotemia • Metabolic acidosis
  • 65. Physical Exam distended and tender abdomen Labs: CBC electrolytes and glucose platelets and coagulation profile DIC profile ABG
  • 66. Abdominal X-ray • signs of bowel obstruction • Ileus with edematous bowel • Pneumatosis intestinalis or intramural air (arrow) • Air in portal vein • pneumoperitoneum
  • 67. Medical Management • No enteral feedings for 10-14 days • NGT on intermittent suction • Hydration and correction of electrolytes • Ventilatory support • Antibiotics • Blood and platelet transfusion if needed
  • 68. • Surgical Indications Absolute Indications 1) bowel perforation 2) intestinal gangrene
  • 69. • Relative Indications – metabolic acidosis – respiratory failure – oliguria, hypovolemia – thrombocytopenia – leucopenia, leukocytosis – air in the portal vein – bowel wall edema – persistent dilated bowel loops
  • 70. • Non-Surgical Indications severe GI hemorrhage abdominal tenderness intestinal obstruction gasless abdomen with ascites