HUMAN PAPILLOMA VIRAL INFECTION 2010

HUMAN PAPILLOMA VIRUS Dr.Abdulrahman Lotfy Preventive Medicine Jahra Hospital

HPV-THE VIRUS HPV-THE INFECTIOUS DISEASE HPV-THE CARCINOGEN HPV/CANCER-THE VACCINE

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Human Papillomavirus Types and Disease Association

Human Papilloma Virus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HPV Types-Low & High Risk ,[object Object],[object Object],[object Object],[object Object],13 % 53%

Pathology and Pathogenesis ,[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],Modes of Transmission

HPV Epidemiology ,[object Object],[object Object],[object Object],[object Object]

Epidemiology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Epidemiology –cont. ,[object Object],[object Object],[object Object]

Infections present with ,[object Object],[object Object],[object Object],[object Object],[object Object]

Clinical Manifestation of HPV ,[object Object],[object Object],[object Object]

Women: Genital warts usually start to appear appear on the vulva, in the vagina, on the cervix, or in the anal area

In men, they appear on the foreskin, head or shaft of the penis, and in the anal area, urethra, and scrotum

Rare skin warts ,[object Object]

HPV – Sexual Transmission ,[object Object],[object Object]

Symptoms of HPV ,[object Object],[object Object],[object Object],[object Object],Pap Test Hybrid Capture II HPV

INTERNAL WARTS Also includes Laryngeal warts (not shown here)

Pap Smear – Cervical Cancer ,[object Object],[object Object],[object Object]

TREATMENT: Low Grade Lesions ,[object Object],[object Object],[object Object],[object Object]

TREATMENT: High Grade Lesions ,[object Object],[object Object],[object Object],[object Object]

TREATMENT: Genital Warts ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

93% of all cervical neoplasia cases test are positive for HPV making it the leading the third leading killer among women Cancer: Predominant types: Co-factors: Skin carcinomas HPV-5, 8 U.V., genetic? Lower genital tract cancers HPV-16, 18, 31, 33 ??? Malignant transformation of respiratory papillomas HPV-6, 11 X-rays

Cervical – HPV infection ,[object Object],[object Object],[object Object],[object Object]

HPV infections predisposes to Cervical Cancer

Human Papillomavirus Vaccine ,[object Object],[object Object],[object Object],[object Object]

Risk with different types of viruses 30, 31, 33, 35, 39, 45, 51 and 53 6, 11, 40, 42 – 44, 54, 61,70, 72 and 81

HPV Vaccine Efficacy* *Among 16-26 year old females. CIN – cervical intraepithelial neoplasia; AIS – adenocarcinoma in situ

HPV Vaccine Efficacy ,[object Object],[object Object],[object Object]

Routine HPV Vaccination Recommendations ,[object Object],[object Object],[object Object],MMWR 2007;56(RR-2):1-24

HPV Vaccination Schedule ,[object Object],[object Object],[object Object],[object Object]

Efficacy of Gardasil HPV induced lesions Cervical Cancer & Precancers (Grade 2/ 3) 1 Vulvar/ Vaginal Precancers (Grade 1- 3) 2 Genital Warts 2 Protection by QHPV 98% 100% 99% 1. The Future II Study Group. Lancet 2007; 369: 1861–68 2.Garland SM et al. New Engl J Med. 2007;356:1928–1943.

HPV Vaccine Special Situations * ,[object Object],[object Object],[object Object],[object Object],[object Object],* Vaccine can be administered

HPV Vaccine Adverse Reactions ,[object Object],[object Object],[object Object],[object Object],*similar to reports in placebo recipients (9%)

Syncope Following Vaccination ,[object Object],[object Object],[object Object],[object Object]

HPV Vaccine Contraindications and Precautions ,[object Object],[object Object],[object Object],[object Object]

HPV Vaccination During Pregnancy ,[object Object],[object Object],[object Object],MMWR 2007;56(RR-2):1-24

HPV Vaccine Storage and Handling ,[object Object],[object Object],[object Object],[object Object]

HUMAN PAPILLOMA VIRAL INFECTION 2010

HUMAN PAPILLOMA VIRAL INFECTION 2010

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HUMAN PAPILLOMA VIRAL INFECTION 2010